YIL084C / SDS3

Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL084C / SDS3

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:4.62|P-value:4.80E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.59|P-value:2.94E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:4.82|P-value:1.93E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.25|P-value:9.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:2.99E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.53|P-value:3.62E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.72|P-value:1.83E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.26|P-value:8.25E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.51|P-value:6.78E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.91|P-value:9.14E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.57|P-value:5.29E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.45|P-value:4.83E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.10|P-value:4.27E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.27|P-value:8.06E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.36|P-value:1.49E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.30|P-value:7.97E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.73|P-value:2.90E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.70|P-value:1.78E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.42|P-value:5.36E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.31|P-value:7.59E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_1958|Compound:st076513|FD-Score:6.15|P-value:1.87E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-3.36|P-value:5.87E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.72|P-value:1.86E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.33|P-value:7.17E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.42|P-value:5.34E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.88|P-value:9.90E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-6.35|P-value:4.64E-10 ID:SGTC_2288|Compound:7946289|FD-Score:-3.48|P-value:3.94E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_2423|Compound:st077119|FD-Score:5.75|P-value:1.76E-8 ID:SGTC_2424|Compound:5537928|FD-Score:6.07|P-value:2.84E-9 ID:SGTC_2442|Compound:5158906|FD-Score:4.01|P-value:6.04E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.74|P-value:1.52E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.31|P-value:7.69E-4 ID:SGTC_2591|Compound:skatole|FD-Score:6.91|P-value:1.68E-11 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.98|P-value:6.76E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.44|P-value:4.98E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.07|P-value:4.88E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_2934|Compound:9036370|FD-Score:5.58|P-value:4.38E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.23|P-value:9.97E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.22|P-value:2.35E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.61|P-value:5.05E-6 ID:SGTC_3055|Compound:9094636|FD-Score:4.81|P-value:2.00E-6 ID:SGTC_3307|Compound:9126885|FD-Score:4.56|P-value:6.23E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:4.62|P-value:4.80E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.59|P-value:2.94E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:4.82|P-value:1.93E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.25|P-value:9.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:2.99E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.53|P-value:3.62E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.72|P-value:1.83E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.26|P-value:8.25E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.51|P-value:6.78E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.91|P-value:9.14E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.57|P-value:5.29E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.45|P-value:4.83E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.10|P-value:4.27E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.27|P-value:8.06E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.36|P-value:1.49E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.30|P-value:7.97E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.73|P-value:2.90E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.70|P-value:1.78E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.42|P-value:5.36E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.31|P-value:7.59E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_1958|Compound:st076513|FD-Score:6.15|P-value:1.87E-9 ID:SGTC_2073|Compound:5212005|FD-Score:-3.36|P-value:5.87E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.72|P-value:1.86E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.33|P-value:7.17E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.42|P-value:5.34E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.88|P-value:9.90E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-6.35|P-value:4.64E-10 ID:SGTC_2288|Compound:7946289|FD-Score:-3.48|P-value:3.94E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_2423|Compound:st077119|FD-Score:5.75|P-value:1.76E-8 ID:SGTC_2424|Compound:5537928|FD-Score:6.07|P-value:2.84E-9 ID:SGTC_2442|Compound:5158906|FD-Score:4.01|P-value:6.04E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.74|P-value:1.52E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.31|P-value:7.69E-4 ID:SGTC_2591|Compound:skatole|FD-Score:6.91|P-value:1.68E-11 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.98|P-value:6.76E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.44|P-value:4.98E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.07|P-value:4.88E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_2934|Compound:9036370|FD-Score:5.58|P-value:4.38E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.23|P-value:9.97E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.22|P-value:2.35E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.61|P-value:5.05E-6 ID:SGTC_3055|Compound:9094636|FD-Score:4.81|P-value:2.00E-6 ID:SGTC_3307|Compound:9126885|FD-Score:4.56|P-value:6.23E-6

Top fitness defect scores for YIL084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2591 skatole 6.91 100.0 µM 1.68E-11 4 2.43E-12
2 SGTC_1958 st076513 6.15 41.9 µM 1.87E-9 60S ribosome export 10 3.99E-10
3 SGTC_2424 5537928 6.07 59.2 µM 2.84E-9 6 6.25E-10
4 SGTC_2423 st077119 5.75 87.2 µM 1.76E-8 3 4.50E-9
5 SGTC_2934 9036370 5.58 36.9 µM 4.38E-8 12 1.21E-8
6 SGTC_153 4077-0274 4.82 519.7 µM 1.93E-6 7 7.24E-7
7 SGTC_3055 9094636 4.81 49.5 µM 2.00E-6 4 7.54E-7
8 SGTC_1514 1189-1591 4.73 158.0 µM 2.90E-6 24 1.13E-6
9 SGTC_24 0417-1663 4.62 219.0 µM 4.80E-6 11 1.94E-6
10 SGTC_3003 9075612 4.61 71.4 µM 5.05E-6 12 2.05E-6
11 SGTC_3307 9126885 4.56 69.3 µM 6.23E-6 21 2.57E-6
12 SGTC_1316 1272-0050 4.36 65.9 µM 1.49E-5 4 6.59E-6
13 SGTC_1930 st074634 4.26 34.3 µM 2.23E-5 RNA pol III & RNase P/MRP 29 1.02E-5
14 SGTC_1186 1319-0216 4.10 26.0 µM 4.27E-5 17 2.06E-5
15 SGTC_2824 7998404 4.07 52.0 µM 4.88E-5 34 2.39E-5
16 SGTC_2442 5158906 4.01 48.5 µM 6.04E-5 21 3.00E-5
17 SGTC_2687 chenodiol 3.98 100.0 µM 6.76E-5 22 3.39E-5
18 SGTC_734 2023-0417 3.91 80.0 µM 9.14E-5 ergosterol biosynthesis 17 4.70E-5
19 SGTC_2274 7947094 3.88 46.1 µM 9.90E-5 38 5.12E-5
20 SGTC_2936 9038235 3.81 15.6 µM 1.32E-4 22 6.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.10E-11 YER181C_d YER181C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.112 7.39E-11 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.111 1.09E-10 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.110 1.57E-10 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.100 5.78E-9 YFL010W-A AUA1 hom Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
0.100 6.10E-9 YCR091W KIN82 hom Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.097 2.07E-8 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.55E-8 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.094 4.95E-8 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.091 1.19E-7 YDL132W CDC53 het Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
0.080 3.08E-6 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.079 4.13E-6 YCL051W LRE1 hom Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
0.077 7.76E-6 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.077 9.20E-6 YDR341C YDR341C het Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076 1.02E-5 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene