YIL085C / KTR7

Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL085C / KTR7

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.73|P-value:7.86E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.24|P-value:4.38E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.27|P-value:4.68E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.01|P-value:2.02E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.37|P-value:3.85E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.15|P-value:7.14E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.37|P-value:2.77E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.31|P-value:3.43E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.16|P-value:5.97E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.73|P-value:6.66E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.05|P-value:8.59E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.77|P-value:5.65E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.81|P-value:4.80E-5 ID:SGTC_1783|Compound:st039459|FD-Score:3.85|P-value:3.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.85|P-value:3.96E-5 ID:SGTC_1831|Compound:st055328|FD-Score:4.08|P-value:1.47E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.40|P-value:1.64E-8 ID:SGTC_2110|Compound:5483698|FD-Score:-3.11|P-value:8.04E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.93|P-value:2.82E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.36|P-value:4.07E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:2.20E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.17|P-value:5.73E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.06|P-value:1.94E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.42|P-value:2.24E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.09|P-value:3.05E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-3.20|P-value:5.91E-4 ID:SGTC_2915|Compound:7971052|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_2919|Compound:7978188|FD-Score:5.25|P-value:3.82E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.45|P-value:1.20E-8 ID:SGTC_2994|Compound:9053520|FD-Score:4.79|P-value:4.77E-7 ID:SGTC_3074|Compound:9116018|FD-Score:-3.39|P-value:2.91E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.51|P-value:1.86E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:3.88E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.89|P-value:3.35E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.61|P-value:1.07E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.73|P-value:7.86E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.24|P-value:4.38E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.27|P-value:4.68E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.01|P-value:2.02E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.37|P-value:3.85E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.15|P-value:7.14E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.37|P-value:2.77E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.31|P-value:3.43E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.16|P-value:5.97E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.73|P-value:6.66E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.05|P-value:8.59E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.77|P-value:5.65E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.81|P-value:4.80E-5 ID:SGTC_1783|Compound:st039459|FD-Score:3.85|P-value:3.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.85|P-value:3.96E-5 ID:SGTC_1831|Compound:st055328|FD-Score:4.08|P-value:1.47E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.40|P-value:1.64E-8 ID:SGTC_2110|Compound:5483698|FD-Score:-3.11|P-value:8.04E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.93|P-value:2.82E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.36|P-value:4.07E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:2.20E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.17|P-value:5.73E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.06|P-value:1.94E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.42|P-value:2.24E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.09|P-value:3.05E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-3.20|P-value:5.91E-4 ID:SGTC_2915|Compound:7971052|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_2919|Compound:7978188|FD-Score:5.25|P-value:3.82E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.45|P-value:1.20E-8 ID:SGTC_2994|Compound:9053520|FD-Score:4.79|P-value:4.77E-7 ID:SGTC_3074|Compound:9116018|FD-Score:-3.39|P-value:2.91E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.51|P-value:1.86E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:3.88E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.89|P-value:3.35E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.61|P-value:1.07E-4

Top fitness defect scores for YIL085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2928 9011484 5.45 9.8 µM 1.20E-8 heme biosynthesis & mitochondrial translocase 12 2.47E-8
2 SGTC_2056 5235370 5.40 200.0 µM 1.64E-8 20 3.35E-8
3 SGTC_2919 7978188 5.25 46.4 µM 3.82E-8 5 7.52E-8
4 SGTC_2994 9053520 4.79 71.4 µM 4.77E-7 RPP1 & pyrimidine depletion 14 8.49E-7
5 SGTC_935 2996-0153 4.37 430.0 µM 3.85E-6 PDR1 14 6.30E-6
6 SGTC_2275 7947463 4.36 200.0 µM 4.07E-6 iron homeostasis 30 6.64E-6
7 SGTC_1831 st055328 4.08 12.0 µM 1.47E-5 heme biosynthesis & mitochondrial translocase 18 2.28E-5
8 SGTC_2915 7971052 4.08 15.2 µM 1.48E-5 6 2.29E-5
9 SGTC_911 3456-4043 4.01 236.0 µM 2.02E-5 mitochondrial processes 24 3.09E-5
10 SGTC_2406 ethylparaben 3.99 405.7 µM 2.20E-5 38 3.36E-5
11 SGTC_2175 5807670 3.93 165.3 µM 2.82E-5 22 4.26E-5
12 SGTC_3093 9117344 3.89 49.5 µM 3.35E-5 60S ribosome export 17 5.02E-5
13 SGTC_1783 st039459 3.85 87.5 µM 3.95E-5 Golgi 23 5.87E-5
14 SGTC_1829 berberine 3.85 14.4 µM 3.96E-5 60S ribosome export 23 5.89E-5
15 SGTC_1739 st037196 3.81 92.5 µM 4.80E-5 29 7.08E-5
16 SGTC_1738 st035555 3.77 74.0 µM 5.65E-5 TSC3-RPN4 36 8.29E-5
17 SGTC_1205 4161-2785 3.73 76.0 µM 6.66E-5 37 9.71E-5
18 SGTC_3328 9140624 3.61 29.0 µM 1.07E-4 28 1.53E-4
19 SGTC_2413 inermin 3.54 26.1 µM 1.42E-4 72 2.01E-4
20 SGTC_1183 1254-0324 3.48 198.0 µM 1.79E-4 39 2.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.72E-12 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.117 1.27E-11 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.110 1.74E-10 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.110 1.98E-10 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.104 1.36E-9 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.087 5.09E-7 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.085 7.81E-7 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.082 2.12E-6 YHL022C SPO11 hom Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
0.080 3.40E-6 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.080 3.60E-6 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.079 4.05E-6 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.079 4.63E-6 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.079 5.21E-6 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.078 5.62E-6 YOR042W CUE5 hom Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.078 6.39E-6 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress