HIPHOP chemogenomics database

YIL086C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL086C / YIL086C

Click on Significant Values for Screen Details

Top fitness defect scores for YIL086C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2251	lansoprazole	6.69	556.0 µM	2.51E-13		4	1.12E-11
2	SGTC_1744	st037937	5.98	38.9 µM	5.13E-11		3	1.08E-9
3	SGTC_725	1497-0963	4.36	19.0 µM	1.25E-6	copper-dependent oxidative stress	14	6.49E-6
4	SGTC_1741	st038134	4.32	10.2 µM	1.56E-6		23	7.84E-6
5	SGTC_1951	sophoraflavanone G	4.29	9.2 µM	1.86E-6	RNA processing & uracil transport	15	9.13E-6
6	SGTC_705	1124-0212	3.89	310.0 µM	1.35E-5		16	5.04E-5
7	SGTC_962	1254-0300	3.84	21.5 µM	1.69E-5		26	6.11E-5
8	SGTC_2163	5671233	3.59	125.0 µM	5.36E-5		35	1.66E-4
9	SGTC_1476	4112-3294	3.56	3.3 µM	6.18E-5	60S ribosome export	29	1.88E-4
10	SGTC_1239	0337-0584	3.52	35.4 µM	7.13E-5	unfolded protein response	74	2.12E-4
11	SGTC_1893	st059353	3.44	36.1 µM	1.03E-4		43	2.91E-4
12	SGTC_2110	5483698	3.42	200.0 µM	1.10E-4	TSC3-RPN4	38	3.10E-4
13	SGTC_1417	3966-0327	3.40	90.4 µM	1.20E-4		31	3.33E-4
14	SGTC_3276	9139060	3.30	49.5 µM	1.82E-4	60S ribosome export	16	4.78E-4
15	SGTC_1204	4049-0315	3.28	18.3 µM	2.04E-4		59	5.28E-4
16	SGTC_3102	9121669	3.20	49.5 µM	2.82E-4		23	6.97E-4
17	SGTC_845	0330-0138	3.19	4.5 µM	2.85E-4		43	7.03E-4
18	SGTC_3258	9138477	3.13	49.5 µM	3.61E-4		25	8.64E-4
19	SGTC_966	1300-0360	3.12	30.2 µM	3.80E-4	heme requiring	60	9.03E-4
20	SGTC_548	1436-0017	3.12	110.0 µM	3.85E-4	TSC3-RPN4	72	9.13E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.132	2.02E-14	YKR048C	NAP1	hom	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.125	3.94E-13	YGL166W	CUP2	hom	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.118	6.91E-12	YML130C	ERO1	het	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.118	7.08E-12	YDR445C_d	YDR445C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115	2.49E-11	YLR327C	TMA10	hom	Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.110	1.98E-10	YLR132C	USB1	het	Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.102	2.62E-9	YLL062C	MHT1	hom	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.097	2.03E-8	YER184C_p	YER184C_p	hom	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
0.096	2.24E-8	YCR036W	RBK1	hom	Putative ribokinase
0.095	3.00E-8	YDR179W-A_p	YDR179W-A_p	hom	Putative protein of unknown function
0.091	1.37E-7	YDL114W_p	YDL114W_p	hom	Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
0.090	1.93E-7	YKR039W	GAP1	hom	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.089	2.38E-7	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.086	6.56E-7	YMR040W	YET2	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.085	9.04E-7	YDR224C	HTB1	het	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation