YIL087C / AIM19

Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL087C / AIM19

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.23|P-value:3.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.01|P-value:1.20E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.91|P-value:1.87E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.71|P-value:4.56E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.79|P-value:3.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.72|P-value:4.36E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.14|P-value:6.35E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.85|P-value:1.55E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:3.08|P-value:5.80E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.68|P-value:5.29E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.39|P-value:1.78E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.70|P-value:4.69E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.46|P-value:1.30E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.16|P-value:2.63E-8 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.27|P-value:3.33E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.21|P-value:4.59E-6 ID:SGTC_1522|Compound:st012842|FD-Score:4.03|P-value:1.06E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.16|P-value:4.35E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.42|P-value:1.56E-6 ID:SGTC_2019|Compound:4016004|FD-Score:5.12|P-value:3.29E-8 ID:SGTC_2081|Compound:5214970|FD-Score:-3.20|P-value:3.77E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.96|P-value:9.09E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_2176|Compound:5809774|FD-Score:2.95|P-value:9.36E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.50|P-value:1.15E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.21|P-value:3.57E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.03|P-value:7.04E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.09|P-value:5.70E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.49|P-value:3.82E-12 ID:SGTC_2481|Compound:5478948|FD-Score:5.13|P-value:3.14E-8 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.05|P-value:6.47E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.59|P-value:7.62E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.34|P-value:2.17E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.12|P-value:5.16E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.04|P-value:6.72E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.42|P-value:1.57E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.37|P-value:1.95E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.00|P-value:7.72E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.35|P-value:2.09E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.10|P-value:5.52E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.23|P-value:3.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.01|P-value:1.20E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.91|P-value:1.87E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.71|P-value:4.56E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.79|P-value:3.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.72|P-value:4.36E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.14|P-value:6.35E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.85|P-value:1.55E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:3.08|P-value:5.80E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.68|P-value:5.29E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.39|P-value:1.78E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.70|P-value:4.69E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.46|P-value:1.30E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.16|P-value:2.63E-8 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.27|P-value:3.33E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.21|P-value:4.59E-6 ID:SGTC_1522|Compound:st012842|FD-Score:4.03|P-value:1.06E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.16|P-value:4.35E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.42|P-value:1.56E-6 ID:SGTC_2019|Compound:4016004|FD-Score:5.12|P-value:3.29E-8 ID:SGTC_2081|Compound:5214970|FD-Score:-3.20|P-value:3.77E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.96|P-value:9.09E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_2176|Compound:5809774|FD-Score:2.95|P-value:9.36E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.50|P-value:1.15E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.21|P-value:3.57E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.03|P-value:7.04E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.09|P-value:5.70E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.49|P-value:3.82E-12 ID:SGTC_2481|Compound:5478948|FD-Score:5.13|P-value:3.14E-8 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.05|P-value:6.47E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.59|P-value:7.62E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.34|P-value:2.17E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.51|P-value:1.06E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.12|P-value:5.16E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.04|P-value:6.72E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.42|P-value:1.57E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.37|P-value:1.95E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.00|P-value:7.72E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.35|P-value:2.09E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.10|P-value:5.52E-4

Top fitness defect scores for YIL087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2479 5617353 6.49 43.9 µM 3.82E-12 3 4.25E-11
2 SGTC_1178 0988-0033 5.16 191.0 µM 2.63E-8 13 1.23E-7
3 SGTC_2481 5478948 5.13 45.2 µM 3.14E-8 PDR1 15 1.45E-7
4 SGTC_2019 4016004 5.12 108.0 µM 3.29E-8 4 1.50E-7
5 SGTC_604 1000-0114 4.85 314.0 µM 1.55E-7 5 6.12E-7
6 SGTC_1019 4262-0212 4.46 3.4 µM 1.30E-6 ergosterol depletion effects on membrane 43 4.17E-6
7 SGTC_1736 st036774 4.42 51.0 µM 1.56E-6 20 4.90E-6
8 SGTC_1508 1080-0625 4.27 72.9 µM 3.33E-6 12 9.75E-6
9 SGTC_1513 0337-0559 4.21 19.0 µM 4.59E-6 13 1.30E-5
10 SGTC_522 1273-0010 4.14 11.6 µM 6.35E-6 60S ribosome export 21 1.75E-5
11 SGTC_1522 st012842 4.03 45.6 µM 1.06E-5 RNA pol III & RNase P/MRP 25 2.77E-5
12 SGTC_116 0155-0182 4.01 31.8 µM 1.20E-5 mitochondrial response to ROS 75 3.09E-5
13 SGTC_785 1270-0111 3.94 65.3 µM 1.62E-5 24 4.08E-5
14 SGTC_168 3970-0862 3.91 530.5 µM 1.87E-5 122 4.63E-5
15 SGTC_497 capsazepine 3.79 133.0 µM 3.23E-5 15 7.60E-5
16 SGTC_503 tyrphostin 8 3.72 294.0 µM 4.36E-5 TSC3-RPN4 39 9.96E-5
17 SGTC_214 4373-3496 3.71 70.0 µM 4.56E-5 75 1.04E-4
18 SGTC_856 0433-0016 3.70 11.3 µM 4.69E-5 18 1.06E-4
19 SGTC_797 k781-0471 3.68 270.0 µM 5.29E-5 RPP1 & pyrimidine depletion 32 1.19E-4
20 SGTC_2565 isoliquiritigenin 3.59 100.0 µM 7.62E-5 44 1.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.24E-11 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.106 6.95E-10 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.102 3.16E-9 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.099 8.03E-9 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.097 1.69E-8 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
0.097 1.70E-8 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.095 4.02E-8 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.090 1.52E-7 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.090 1.52E-7 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.090 1.66E-7 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.79E-7 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.090 1.86E-7 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.089 2.58E-7 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.088 3.78E-7 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.087 4.41E-7 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p