YIL088C / AVT7

Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL088C / AVT7

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.40|P-value:9.28E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.81|P-value:1.31E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:2.95|P-value:5.70E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.61|P-value:3.63E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.97|P-value:5.63E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.51|P-value:5.85E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:2.90|P-value:6.83E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.01|P-value:4.81E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.01|P-value:4.43E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.64|P-value:3.06E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.02|P-value:4.35E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.86|P-value:1.06E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.87|P-value:9.77E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.99|P-value:5.09E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.61|P-value:3.47E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:2.94|P-value:5.95E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.44|P-value:8.09E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.65|P-value:3.06E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.73|P-value:2.00E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.08|P-value:3.43E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:2.90|P-value:7.01E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.81|P-value:9.83E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.05|P-value:3.91E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.07|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.33|P-value:1.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.02|P-value:5.04E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-2.95|P-value:6.10E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.89|P-value:9.16E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.84|P-value:8.74E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.53|P-value:5.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.90|P-value:3.98E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-2.94|P-value:6.35E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.12|P-value:2.89E-4 ID:SGTC_2038|Compound:4100038|FD-Score:2.92|P-value:6.44E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:1.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.80|P-value:9.87E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.89|P-value:7.48E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.29|P-value:1.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-6.20|P-value:4.73E-12 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:7.65E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.85|P-value:1.19E-5 ID:SGTC_2804|Compound:7954240|FD-Score:6.28|P-value:2.31E-12 ID:SGTC_2805|Compound:7950783|FD-Score:-5.65|P-value:2.73E-10 ID:SGTC_2813|Compound:7971799|FD-Score:-5.69|P-value:1.98E-10 ID:SGTC_2893|Compound:9048488|FD-Score:-3.09|P-value:3.53E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.93|P-value:6.10E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.95|P-value:5.64E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.18|P-value:2.28E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.67|P-value:2.62E-5 ID:SGTC_3237|Compound:9133362|FD-Score:2.92|P-value:6.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.21|P-value:1.76E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.40|P-value:9.28E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.81|P-value:1.31E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:2.95|P-value:5.70E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.61|P-value:3.63E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.97|P-value:5.63E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.51|P-value:5.85E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:2.90|P-value:6.83E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.01|P-value:4.81E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.01|P-value:4.43E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.64|P-value:3.06E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.02|P-value:4.35E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.86|P-value:1.06E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.87|P-value:9.77E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.99|P-value:5.09E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.61|P-value:3.47E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:2.94|P-value:5.95E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.44|P-value:8.09E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.65|P-value:3.06E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.73|P-value:2.00E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.08|P-value:3.43E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:2.90|P-value:7.01E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.81|P-value:9.83E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.05|P-value:3.91E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.07|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.33|P-value:1.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.02|P-value:5.04E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-2.95|P-value:6.10E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.89|P-value:9.16E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.84|P-value:8.74E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.53|P-value:5.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.90|P-value:3.98E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-2.94|P-value:6.35E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.12|P-value:2.89E-4 ID:SGTC_2038|Compound:4100038|FD-Score:2.92|P-value:6.44E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:1.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.80|P-value:9.87E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-2.89|P-value:7.48E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.29|P-value:1.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-6.20|P-value:4.73E-12 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:7.65E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.85|P-value:1.19E-5 ID:SGTC_2804|Compound:7954240|FD-Score:6.28|P-value:2.31E-12 ID:SGTC_2805|Compound:7950783|FD-Score:-5.65|P-value:2.73E-10 ID:SGTC_2813|Compound:7971799|FD-Score:-5.69|P-value:1.98E-10 ID:SGTC_2893|Compound:9048488|FD-Score:-3.09|P-value:3.53E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.93|P-value:6.10E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.95|P-value:5.64E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.18|P-value:2.28E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.67|P-value:2.62E-5 ID:SGTC_3237|Compound:9133362|FD-Score:2.92|P-value:6.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.21|P-value:1.76E-6

Top fitness defect scores for YIL088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2804 7954240 6.28 19.5 µM 2.31E-12 3 1.71E-10
2 SGTC_1676 st018489 5.90 23.4 µM 3.98E-11 60S ribosome export 5 1.81E-9
3 SGTC_3255 9139072 4.21 49.5 µM 1.76E-6 10 1.29E-5
4 SGTC_1569 carminic acid 3.89 40.6 µM 9.16E-6 16 5.09E-5
5 SGTC_840 0245-0196 3.87 390.0 µM 9.77E-6 15 5.37E-5
6 SGTC_747 3448-8087 3.86 38.7 µM 1.06E-5 29 5.74E-5
7 SGTC_75 0159-0059 3.81 199.0 µM 1.31E-5 fatty acid desaturase (OLE1) 22 6.87E-5
8 SGTC_965 1291-5240 3.73 308.0 µM 2.00E-5 36 9.75E-5
9 SGTC_1587 estradiol valerate 3.71 56.1 µM 2.12E-5 16 1.02E-4
10 SGTC_3234 9132280 3.67 49.5 µM 2.62E-5 27 1.22E-4
11 SGTC_577 r071-0003 3.64 38.6 µM 3.06E-5 fatty acid desaturase (OLE1) 73 1.39E-4
12 SGTC_853 0419-0306 3.61 21.0 µM 3.47E-5 25 1.54E-4
13 SGTC_2000 st075254 3.37 36.4 µM 1.02E-4 23 3.80E-4
14 SGTC_1269 0831-0796 3.33 3.0 µM 1.18E-4 60S ribosome export 30 4.29E-4
15 SGTC_2066 5222451 3.29 176.0 µM 1.40E-4 heme biosynthesis & mitochondrial translocase 58 4.93E-4
16 SGTC_2569 tetrandrine 3.29 100.0 µM 1.40E-4 50 4.93E-4
17 SGTC_1788 fluconazole 3.19 20.0 µM 2.20E-4 azole & statin 96 7.19E-4
18 SGTC_3218 9131285 3.18 49.5 µM 2.28E-4 endomembrane recycling 91 7.40E-4
19 SGTC_2020 4017018 3.12 200.0 µM 2.89E-4 55 9.04E-4
20 SGTC_1033 k072-0102 3.08 21.3 µM 3.43E-4 60S ribosome export 60 0.00104

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 7.17E-24 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.151 1.22E-18 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.132 1.50E-14 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.131 2.34E-14 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.129 8.93E-14 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.121 2.00E-12 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
0.115 2.48E-11 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.112 7.46E-11 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.112 8.51E-11 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.111 1.21E-10 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.108 3.43E-10 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.107 4.74E-10 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.102 2.98E-9 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.102 3.78E-9 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.099 8.42E-9 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation