YIL090W / ICE2

Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL090W / ICE2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:5.45|P-value:7.32E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:6.09|P-value:2.14E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:6.92|P-value:1.23E-11 ID:SGTC_77|Compound:0828-0286|FD-Score:3.47|P-value:4.22E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.53|P-value:1.84E-20 ID:SGTC_90|Compound:0870-0863|FD-Score:4.01|P-value:5.53E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.43|P-value:8.34E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:9.05|P-value:1.32E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:6.99|P-value:8.08E-12 ID:SGTC_158|Compound:k038-0087|FD-Score:5.65|P-value:2.63E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:10.20|P-value:4.54E-23 ID:SGTC_177|Compound:1327-0068|FD-Score:5.02|P-value:6.61E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:4.56|P-value:5.59E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:4.06|P-value:4.58E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.81|P-value:1.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.25|P-value:8.88E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.31|P-value:7.28E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.57|P-value:2.95E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.09|P-value:4.63E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:5.51|P-value:5.39E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:3.22|P-value:9.80E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.50|P-value:5.82E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.90|P-value:8.58E-5 ID:SGTC_1571|Compound:st070080|FD-Score:-4.21|P-value:2.27E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.03|P-value:4.72E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.33|P-value:6.63E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.34|P-value:6.07E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.21|P-value:9.36E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.74|P-value:1.60E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.67|P-value:2.02E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.28|P-value:8.01E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.81|P-value:1.12E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.82|P-value:9.94E-9 ID:SGTC_2801|Compound:7907800|FD-Score:3.59|P-value:2.68E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.13|P-value:3.44E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.20|P-value:9.74E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.08|P-value:4.31E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.90|P-value:8.53E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.34|P-value:1.34E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.40|P-value:5.28E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.33|P-value:1.49E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.45|P-value:7.32E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:6.09|P-value:2.14E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:6.92|P-value:1.23E-11 ID:SGTC_77|Compound:0828-0286|FD-Score:3.47|P-value:4.22E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.53|P-value:1.84E-20 ID:SGTC_90|Compound:0870-0863|FD-Score:4.01|P-value:5.53E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.43|P-value:8.34E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:9.05|P-value:1.32E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:6.99|P-value:8.08E-12 ID:SGTC_158|Compound:k038-0087|FD-Score:5.65|P-value:2.63E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:10.20|P-value:4.54E-23 ID:SGTC_177|Compound:1327-0068|FD-Score:5.02|P-value:6.61E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:4.56|P-value:5.59E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:4.06|P-value:4.58E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.81|P-value:1.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.25|P-value:8.88E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.31|P-value:7.28E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.57|P-value:2.95E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.09|P-value:4.63E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:5.51|P-value:5.39E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:3.22|P-value:9.80E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.50|P-value:5.82E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.90|P-value:8.58E-5 ID:SGTC_1571|Compound:st070080|FD-Score:-4.21|P-value:2.27E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.03|P-value:4.72E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.33|P-value:6.63E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.34|P-value:6.07E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.21|P-value:9.36E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.74|P-value:1.60E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.67|P-value:2.02E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.28|P-value:8.01E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.81|P-value:1.12E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.82|P-value:9.94E-9 ID:SGTC_2801|Compound:7907800|FD-Score:3.59|P-value:2.68E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.13|P-value:3.44E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.20|P-value:9.74E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.08|P-value:4.31E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.90|P-value:8.53E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-4.34|P-value:1.34E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.40|P-value:5.28E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.33|P-value:1.49E-5

Top fitness defect scores for YIL090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 10.20 2.7 µM 4.54E-23 mitochondrial stress 39 1.20E-24
2 SGTC_86 0417-1630 9.53 471.9 µM 1.84E-20 ubiquinone biosynthesis & proteasome 44 7.54E-22
3 SGTC_137 0438-0332 9.05 85.4 µM 1.32E-18 ubiquinone biosynthesis & proteasome 29 7.41E-20
4 SGTC_142 0335-0849 6.99 62.7 µM 8.08E-12 ubiquinone biosynthesis & proteasome 52 1.41E-12
5 SGTC_67 0335-0847 6.92 266.0 µM 1.23E-11 ubiquinone biosynthesis & proteasome 54 2.22E-12
6 SGTC_64 000l-0018 6.09 272.1 µM 2.14E-9 ubiquinone biosynthesis & proteasome 78 5.58E-10
7 SGTC_2762 leflunomide 5.82 42.1 µM 9.94E-9 4 2.90E-9
8 SGTC_158 k038-0087 5.65 26.4 µM 2.63E-8 ubiquinone biosynthesis & proteasome 76 8.22E-9
9 SGTC_794 k038-0031 5.51 316.0 µM 5.39E-8 ubiquinone biosynthesis & proteasome 69 1.78E-8
10 SGTC_1072 oxiconazole 5.50 14.9 nM 5.82E-8 ergosterol depletion effects on membrane 25 1.93E-8
11 SGTC_36 0335-0881 5.45 14.2 µM 7.32E-8 ubiquinone biosynthesis & proteasome 76 2.47E-8
12 SGTC_103 0844-0104 5.43 51.8 µM 8.34E-8 ERAD & cell cycle 88 2.84E-8
13 SGTC_768 0384-0033 5.09 77.3 µM 4.63E-7 fatty acid desaturase (OLE1) 52 1.78E-7
14 SGTC_177 1327-0068 5.02 8.4 µM 6.61E-7 25 2.61E-7
15 SGTC_315 k915-0449 4.81 187.0 µM 1.81E-6 35 7.68E-7
16 SGTC_200 k038-0079 4.56 37.5 µM 5.59E-6 ubiquinone biosynthesis & proteasome 44 2.57E-6
17 SGTC_3192 9110362 4.33 49.5 µM 1.49E-5 mitochondrial processes 7 7.34E-6
18 SGTC_1161 k007-0610 4.33 110.0 µM 1.54E-5 ERAD & cell cycle 105 7.61E-6
19 SGTC_2947 9072639 4.13 7.7 µM 3.44E-5 tubulin folding & SWR complex 36 1.80E-5
20 SGTC_2992 9074591 4.08 71.4 µM 4.31E-5 15 2.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.511 8.03E-223 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.445 8.70E-163 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.438 3.28E-157 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.423 4.30E-146 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.422 3.48E-145 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.421 1.13E-144 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.418 1.20E-141 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.415 3.49E-140 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.411 2.67E-137 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.407 7.26E-134 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.404 1.24E-131 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.403 6.21E-131 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.398 7.54E-128 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.396 5.59E-126 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.391 4.95E-123 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W