YIL091C / UTP25

Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL091C / UTP25

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.00|P-value:1.98E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:4.45|P-value:2.48E-6 ID:SGTC_33|Compound:0986-0033|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.19|P-value:5.20E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.02|P-value:9.84E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.97|P-value:2.30E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.00|P-value:1.91E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.65|P-value:8.89E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:5.02E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-4.16|P-value:9.29E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.77|P-value:5.23E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.91|P-value:6.27E-10 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.09|P-value:7.50E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.81|P-value:4.61E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.14|P-value:6.26E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.84|P-value:3.99E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:5.28|P-value:2.97E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:8.10E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.85|P-value:3.06E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.94|P-value:2.57E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-4.16|P-value:9.39E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.48|P-value:1.73E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.75|P-value:5.83E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.76|P-value:5.70E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.38|P-value:2.63E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.16|P-value:5.76E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.03|P-value:9.28E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.24|P-value:4.32E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.80|P-value:4.88E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.26|P-value:4.07E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.24|P-value:4.46E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.14|P-value:6.11E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.22|P-value:4.71E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.11|P-value:7.02E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.05|P-value:8.60E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.92|P-value:2.80E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.85|P-value:3.88E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.23|P-value:7.15E-6 ID:SGTC_1964|Compound:st076914|FD-Score:-3.87|P-value:3.44E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.26|P-value:4.11E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.54|P-value:1.38E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.01|P-value:9.79E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.04|P-value:8.81E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.04|P-value:8.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.03|P-value:1.75E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.58|P-value:1.14E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.81|P-value:4.67E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.08|P-value:7.76E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.90|P-value:3.06E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.00|P-value:1.98E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:4.45|P-value:2.48E-6 ID:SGTC_33|Compound:0986-0033|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.19|P-value:5.20E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.02|P-value:9.84E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.97|P-value:2.30E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.00|P-value:1.91E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.65|P-value:8.89E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:5.02E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-4.16|P-value:9.29E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.77|P-value:5.23E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.91|P-value:6.27E-10 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.09|P-value:7.50E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.81|P-value:4.61E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.14|P-value:6.26E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.84|P-value:3.99E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:5.28|P-value:2.97E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:8.10E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.85|P-value:3.06E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.94|P-value:2.57E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-4.16|P-value:9.39E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.48|P-value:1.73E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.75|P-value:5.83E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.76|P-value:5.70E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.38|P-value:2.63E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.16|P-value:5.76E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.01|P-value:1.94E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.03|P-value:9.28E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.24|P-value:4.32E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.54|P-value:1.41E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.80|P-value:4.88E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.26|P-value:4.07E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.24|P-value:4.46E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.14|P-value:6.11E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.22|P-value:4.71E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.11|P-value:7.02E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.05|P-value:8.60E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.92|P-value:2.80E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.85|P-value:3.88E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.23|P-value:7.15E-6 ID:SGTC_1964|Compound:st076914|FD-Score:-3.87|P-value:3.44E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.26|P-value:4.11E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.54|P-value:1.38E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.01|P-value:9.79E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.04|P-value:8.81E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.04|P-value:8.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.03|P-value:1.75E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.58|P-value:1.14E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.81|P-value:4.67E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.08|P-value:7.76E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.90|P-value:3.06E-5

Top fitness defect scores for YIL091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_541 4513-1321 5.91 94.0 µM 6.27E-10 4 1.66E-9 0.72
2 SGTC_882 0843-0131 5.28 351.0 µM 2.97E-8 3 6.49E-8 0.13
3 SGTC_26 0302-0163 4.45 425.2 µM 2.48E-6 heme biosynthesis & mitochondrial translocase 7 4.33E-6 0.46
4 SGTC_1750 st081859 4.23 2.4 µM 7.15E-6 endomembrane recycling 28 1.19E-5 0.24
5 SGTC_33 0986-0033 4.07 35.8 µM 1.45E-5 calcium & mitochondrial duress 3 2.32E-5 0.76
6 SGTC_2629 bisabolol 4.03 100.0 µM 1.75E-5 8 2.77E-5 0.17
7 SGTC_1154 4088-0362 4.01 150.0 µM 1.94E-5 7 3.07E-5 0.01
8 SGTC_21 0849-0113 4.00 23.0 µM 1.98E-5 8 3.13E-5 0.57
9 SGTC_139 0099-0334 3.97 718.6 µM 2.30E-5 6 3.60E-5 0.15
10 SGTC_1735 st034310 3.92 56.8 µM 2.80E-5 Golgi 10 4.34E-5 0.17
11 SGTC_1736 st036774 3.85 51.0 µM 3.88E-5 3 5.91E-5 0.07
12 SGTC_805 3852-0218 3.84 479.0 µM 3.99E-5 ERAD & cell cycle 10 6.07E-5 0.05
13 SGTC_41 0478-0632 3.84 82.6 µM 4.10E-5 14 6.23E-5 0.03
14 SGTC_764 1951-2361 3.81 146.0 µM 4.61E-5 16 6.97E-5 8.85E-4
15 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.81 100.0 µM 4.67E-5 6 7.05E-5 0.20
16 SGTC_1323 1348-1351 3.80 11.2 µM 4.88E-5 4 7.35E-5 0.73
17 SGTC_1004 4084-0029 3.76 199.0 µM 5.70E-5 3 8.53E-5 0.10
18 SGTC_953 1188-0045 3.67 9.7 µM 8.10E-5 60S ribosome export 8 1.19E-4 0.01
19 SGTC_230 MPP+ 3.65 141.7 µM 8.89E-5 8 1.30E-4 0.11
20 SGTC_1495 4469-0029 3.57 237.0 µM 1.26E-4 8 1.82E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.76E-12 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.110 1.69E-10 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.100 7.19E-9 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.099 8.86E-9 YPR153W YPR153W hom Putative protein of unknown function
0.092 9.63E-8 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.089 2.46E-7 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.088 3.21E-7 YBR136W MEC1 het Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
0.088 3.48E-7 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.085 7.18E-7 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.083 1.66E-6 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.081 2.39E-6 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.081 2.80E-6 YMR255W GFD1 hom Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress
0.079 4.80E-6 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.079 5.16E-6 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.072 2.64E-5 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress