HIPHOP chemogenomics database
YIL091C / UTP25 
Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YIL091C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 1.76E-12 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
| 0.110 | 1.69E-10 | YPR029C | APL4 | hom | Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport |
| 0.100 | 7.19E-9 | YBR050C | REG2 | hom | Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease |
| 0.099 | 8.86E-9 | YPR153W | YPR153W | hom | Putative protein of unknown function |
| 0.092 | 9.63E-8 | YJR041C | URB2 | het | Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis |
| 0.089 | 2.46E-7 | YGL067W | NPY1 | hom | NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member |
| 0.088 | 3.21E-7 | YBR136W | MEC1 | het | Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres |
| 0.088 | 3.48E-7 | YMR230W-A_p | YMR230W-A_p | hom | Putative protein of unknown function |
| 0.085 | 7.18E-7 | YMR029C | FAR8 | hom | Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p |
| 0.083 | 1.66E-6 | YPR173C | VPS4 | hom | AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism |
| 0.081 | 2.39E-6 | YKL098W | MTC2 | hom | Protein of unknown function; mtc2 is synthetically sick with cdc13-1 |
| 0.081 | 2.80E-6 | YMR255W | GFD1 | hom | Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress |
| 0.079 | 4.80E-6 | YML072C | TCB3 | hom | Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact |
| 0.079 | 5.16E-6 | YCL046W_d | YCL046W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C |
| 0.072 | 2.64E-5 | YKR014C | YPT52 | hom | Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress |