YIL092W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL092W / YIL092W

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:-3.37|P-value:2.44E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.01|P-value:1.89E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.52|P-value:1.39E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.31|P-value:3.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.22|P-value:6.36E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.47|P-value:2.21E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:-6.16|P-value:1.04E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.16|P-value:5.36E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:2.46E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.05|P-value:8.84E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.89|P-value:3.19E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.85|P-value:3.50E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.82|P-value:4.30E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.46|P-value:2.27E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:4.07|P-value:1.46E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.81|P-value:4.61E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.60|P-value:9.84E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.73|P-value:6.41E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.01|P-value:1.72E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.16|P-value:8.40E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.01|P-value:9.24E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.23|P-value:4.59E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:9.14|P-value:2.62E-21 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.41|P-value:2.61E-6 ID:SGTC_1554|Compound:st069299|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.94|P-value:2.36E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-3.45|P-value:1.80E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.31|P-value:4.15E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.46|P-value:1.86E-4 ID:SGTC_2064|Compound:5220758|FD-Score:6.54|P-value:8.34E-12 ID:SGTC_2078|Compound:5212016|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.57|P-value:1.25E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.12|P-value:6.26E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.29|P-value:3.67E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.78|P-value:4.58E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-3.77|P-value:4.89E-5 ID:SGTC_2362|Compound:9071156|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.79|P-value:4.53E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-4.01|P-value:1.72E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.59|P-value:1.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.23|P-value:4.12E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.21|P-value:4.13E-8 ID:SGTC_2505|Compound:galangin|FD-Score:-3.08|P-value:7.27E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.17|P-value:5.28E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.78|P-value:5.14E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.88|P-value:3.07E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.31|P-value:3.07E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.29|P-value:3.61E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.69|P-value:7.44E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.37|P-value:2.44E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.01|P-value:1.89E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.52|P-value:1.39E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.31|P-value:3.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.22|P-value:6.36E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.47|P-value:2.21E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:-6.16|P-value:1.04E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.16|P-value:5.36E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:2.46E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.05|P-value:8.84E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.89|P-value:3.19E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.85|P-value:3.50E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.82|P-value:4.30E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.46|P-value:2.27E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:4.07|P-value:1.46E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.81|P-value:4.61E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.60|P-value:9.84E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.73|P-value:6.41E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.01|P-value:1.72E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.16|P-value:8.40E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.01|P-value:9.24E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.23|P-value:4.59E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:9.14|P-value:2.62E-21 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.41|P-value:2.61E-6 ID:SGTC_1554|Compound:st069299|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.94|P-value:2.36E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-3.45|P-value:1.80E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.31|P-value:4.15E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.46|P-value:1.86E-4 ID:SGTC_2064|Compound:5220758|FD-Score:6.54|P-value:8.34E-12 ID:SGTC_2078|Compound:5212016|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.57|P-value:1.25E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.12|P-value:6.26E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.29|P-value:3.67E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.78|P-value:4.58E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-3.77|P-value:4.89E-5 ID:SGTC_2362|Compound:9071156|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.79|P-value:4.53E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-4.01|P-value:1.72E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.59|P-value:1.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.23|P-value:4.12E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.21|P-value:4.13E-8 ID:SGTC_2505|Compound:galangin|FD-Score:-3.08|P-value:7.27E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.17|P-value:5.28E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.78|P-value:5.14E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.88|P-value:3.07E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.31|P-value:3.07E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.29|P-value:3.61E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.69|P-value:7.44E-5

Top fitness defect scores for YIL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1377 2944-0135 9.14 198.0 µM 2.62E-21 calcium & mitochondrial duress 6 3.21E-20
2 SGTC_2064 5220758 6.54 200.0 µM 8.34E-12 9 2.99E-11
3 SGTC_2501 sodium tetradecyl sulfate 5.21 13.4 µM 4.13E-8 14 9.24E-8
4 SGTC_367 0335-0881 4.47 7.1 µM 2.21E-6 ubiquinone biosynthesis & proteasome 57 3.98E-6
5 SGTC_891 0929-0073 4.46 133.0 µM 2.27E-6 14 4.09E-6
6 SGTC_910 3454-3003 4.07 490.0 µM 1.46E-5 13 2.38E-5
7 SGTC_145 3737-0113 4.01 38.4 µM 1.89E-5 DNA intercalators 73 3.03E-5
8 SGTC_746 1095-0025 3.89 46.6 µM 3.19E-5 RSC & ERG11 16 4.99E-5
9 SGTC_864 0469-0573 3.82 172.0 µM 4.30E-5 23 6.62E-5
10 SGTC_913 3487-1245 3.81 167.0 µM 4.61E-5 35 7.07E-5
11 SGTC_2851 9015922 3.78 71.4 µM 5.14E-5 46 7.85E-5
12 SGTC_1044 1222-0021 3.73 1.8 µM 6.41E-5 heme biosynthesis & mitochondrial translocase 45 9.66E-5
13 SGTC_3326 9140064 3.69 16.4 µM 7.44E-5 26 1.11E-4
14 SGTC_2080 5212524 3.57 12.4 µM 1.25E-4 copper-dependent oxidative stress 23 1.82E-4
15 SGTC_2078 5212016 3.54 200.0 µM 1.37E-4 60S ribosome export 25 1.99E-4
16 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.48 54.6 µM 1.72E-4 RPP1 & pyrimidine depletion 43 2.47E-4
17 SGTC_2010 4012422 3.46 159.0 µM 1.86E-4 40 2.65E-4
18 SGTC_203 k066-0004 3.36 30.9 µM 2.79E-4 RSC & ERG11 36 3.89E-4
19 SGTC_3207 9114163 3.29 49.5 µM 3.61E-4 59 4.98E-4
20 SGTC_2220 6782180 3.29 200.0 µM 3.67E-4 RNA processing & uracil transport 15 5.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.52E-11 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.108 3.10E-10 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.094 4.68E-8 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.36E-7 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.089 2.27E-7 YHR185C PFS1 hom Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
0.087 4.39E-7 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.084 1.11E-6 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.079 4.39E-6 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication
0.079 4.40E-6 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.079 4.96E-6 YPL136W_d YPL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
0.077 7.36E-6 YCL042W_p YCL042W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.075 1.46E-5 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.070 4.73E-5 YCR069W CPR4 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
0.070 4.89E-5 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.070 5.45E-5 YKR072C SIS2 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis