YIL093C / RSM25

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL093C / RSM25

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.64|P-value:1.52E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.46|P-value:2.95E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.05|P-value:1.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.16|P-value:1.57E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.97|P-value:3.95E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:2.92E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.13|P-value:9.98E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.48|P-value:8.55E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.86|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.69|P-value:2.07E-18 ID:SGTC_204|Compound:1543-0184|FD-Score:3.54|P-value:7.10E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.50|P-value:3.61E-29 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.87|P-value:3.19E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.01|P-value:2.04E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:16.20|P-value:6.02E-48 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.54|P-value:9.01E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.96|P-value:5.80E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.51|P-value:9.93E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:4.12|P-value:1.02E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:3.20E-22 ID:SGTC_365|Compound:0121-0052|FD-Score:3.73|P-value:3.82E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.51|P-value:3.69E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.61|P-value:5.69E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.62|P-value:7.01E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-3.66|P-value:6.36E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.73|P-value:1.32E-7 ID:SGTC_748|Compound:0136-0228|FD-Score:3.58|P-value:6.21E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.46|P-value:3.03E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.95|P-value:4.36E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.84|P-value:6.69E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.86|P-value:2.53E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.72|P-value:3.98E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.70|P-value:4.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.16|P-value:8.92E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.47|P-value:8.66E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.43|P-value:9.81E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.76|P-value:3.51E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.57|P-value:6.47E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.52|P-value:7.45E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.72|P-value:1.08E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.65|P-value:5.04E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.69|P-value:5.68E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.00|P-value:2.11E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.70|P-value:2.78E-30 ID:SGTC_1745|Compound:st081495|FD-Score:3.92|P-value:2.05E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.51|P-value:5.48E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.40|P-value:3.78E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.81|P-value:7.55E-6 ID:SGTC_1944|Compound:st076371|FD-Score:4.92|P-value:4.79E-6 ID:SGTC_1995|Compound:st072814|FD-Score:5.56|P-value:3.03E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.66|P-value:4.82E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.52|P-value:9.73E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.43|P-value:3.39E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.66|P-value:6.28E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.71|P-value:1.14E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.60|P-value:5.79E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.58|P-value:6.26E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.57|P-value:2.71E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.21|P-value:7.40E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.98|P-value:2.26E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.69|P-value:1.23E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.67|P-value:4.75E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.76|P-value:3.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.03|P-value:2.27E-10 ID:SGTC_2950|Compound:9072895|FD-Score:3.79|P-value:3.18E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.60|P-value:5.88E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.52|P-value:3.23E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.64|P-value:1.52E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.46|P-value:2.95E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.05|P-value:1.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.16|P-value:1.57E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.97|P-value:3.95E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:2.92E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.13|P-value:9.98E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.48|P-value:8.55E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.86|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.69|P-value:2.07E-18 ID:SGTC_204|Compound:1543-0184|FD-Score:3.54|P-value:7.10E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.50|P-value:3.61E-29 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.87|P-value:3.19E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.01|P-value:2.04E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:16.20|P-value:6.02E-48 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.54|P-value:9.01E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.96|P-value:5.80E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.51|P-value:9.93E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:4.12|P-value:1.02E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:3.20E-22 ID:SGTC_365|Compound:0121-0052|FD-Score:3.73|P-value:3.82E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.51|P-value:3.69E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.61|P-value:5.69E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.62|P-value:7.01E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-3.66|P-value:6.36E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.73|P-value:1.32E-7 ID:SGTC_748|Compound:0136-0228|FD-Score:3.58|P-value:6.21E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.46|P-value:3.03E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.95|P-value:4.36E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.84|P-value:6.69E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.86|P-value:2.53E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.72|P-value:3.98E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.70|P-value:4.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.16|P-value:8.92E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.47|P-value:8.66E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.43|P-value:9.81E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.76|P-value:3.51E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.57|P-value:6.47E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.52|P-value:7.45E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.72|P-value:1.08E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.65|P-value:5.04E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.69|P-value:5.68E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.00|P-value:2.11E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.70|P-value:2.78E-30 ID:SGTC_1745|Compound:st081495|FD-Score:3.92|P-value:2.05E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.51|P-value:5.48E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.40|P-value:3.78E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.81|P-value:7.55E-6 ID:SGTC_1944|Compound:st076371|FD-Score:4.92|P-value:4.79E-6 ID:SGTC_1995|Compound:st072814|FD-Score:5.56|P-value:3.03E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.66|P-value:4.82E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.52|P-value:9.73E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.43|P-value:3.39E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.66|P-value:6.28E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.71|P-value:1.14E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.60|P-value:5.79E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.58|P-value:6.26E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.57|P-value:2.71E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.21|P-value:7.40E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.98|P-value:2.26E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.69|P-value:1.23E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.67|P-value:4.75E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.76|P-value:3.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.03|P-value:2.27E-10 ID:SGTC_2950|Compound:9072895|FD-Score:3.79|P-value:3.18E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.60|P-value:5.88E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.52|P-value:3.23E-5

Top fitness defect scores for YIL093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_275 trichlorophene 16.20 5.7 µM 6.02E-48 mitochondrial stress 6 1.74E-59
2 SGTC_1742 st038235 12.70 28.9 µM 2.78E-30 mitochondrial stress 4 2.37E-37
3 SGTC_236 1509-0011 12.50 5.3 µM 3.61E-29 140 5.87E-36
4 SGTC_310 1273-0058 10.80 1.1 µM 3.20E-22 mitochondrial stress 34 2.90E-27
5 SGTC_173 1273-0061 9.69 2.7 µM 2.07E-18 mitochondrial stress 41 1.68E-22
6 SGTC_116 0155-0182 6.16 31.8 µM 1.57E-8 mitochondrial response to ROS 23 3.53E-10
7 SGTC_673 1082-0474 5.73 110.0 µM 1.32E-7 RSC complex & mRNA processing 25 4.98E-9
8 SGTC_1995 st072814 5.56 61.1 µM 3.03E-7 1 1.39E-8
9 SGTC_404 fumagillin 5.51 50.0 µM 3.69E-7 2 1.77E-8
10 SGTC_118 0083-0097 4.97 135.3 µM 3.95E-6 translation 59 3.35E-7
11 SGTC_831 k061-1017 4.95 217.0 µM 4.36E-6 translation 23 3.78E-7
12 SGTC_1944 st076371 4.92 56.9 µM 4.79E-6 10 4.25E-7
13 SGTC_908 3448-7491 4.84 47.7 µM 6.69E-6 mitochondrial stress 84 6.43E-7
14 SGTC_1922 5578187 4.81 25.0 µM 7.55E-6 TRP & mitochondrial translation 12 7.46E-7
15 SGTC_1674 st016616 4.72 23.6 µM 1.08E-5 13 1.17E-6
16 SGTC_2409 alverine citrate 4.71 64.0 µM 1.14E-5 37 1.24E-6
17 SGTC_2830 7992007 4.69 71.4 µM 1.23E-5 12 1.36E-6
18 SGTC_10 0279-0212 4.64 42.6 µM 1.52E-5 TRP & mitochondrial translation 79 1.77E-6
19 SGTC_119 0121-0043 4.47 24.8 µM 2.92E-5 mitochondrial stress 79 3.97E-6
20 SGTC_19 0279-0214 4.46 38.4 µM 2.95E-5 TRP & mitochondrial translation 31 4.02E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.467 4.74E-181 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.446 2.99E-163 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.437 3.43E-156 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.437 2.54E-156 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.426 2.20E-148 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.417 1.13E-140 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.417 5.52E-141 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.414 2.49E-139 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.414 2.70E-139 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.413 9.19E-139 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.409 7.28E-136 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.407 5.65E-134 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.406 1.98E-133 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.404 9.11E-132 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.401 4.55E-130 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)