YIL096C_p

Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL096C / YIL096C

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:5.20|P-value:1.33E-7 ID:SGTC_183|Compound:3914-0051|FD-Score:4.05|P-value:2.96E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.12|P-value:1.95E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.09|P-value:2.99E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.35|P-value:5.80E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:4.31|P-value:9.59E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.57|P-value:2.95E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:5.14|P-value:1.75E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:3.97|P-value:4.15E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.49|P-value:4.25E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.67|P-value:1.81E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.35|P-value:4.39E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.35|P-value:4.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.92|P-value:6.02E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.07|P-value:2.77E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.78|P-value:8.91E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.74|P-value:1.02E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.18|P-value:7.85E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.27|P-value:5.82E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.16|P-value:8.41E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.41|P-value:3.58E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.29|P-value:6.44E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.82|P-value:7.59E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.36|P-value:5.05E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.12|P-value:9.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.96|P-value:5.21E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.40|P-value:6.41E-6 ID:SGTC_2368|Compound:9071271|FD-Score:5.22|P-value:1.20E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.39|P-value:4.51E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-4.11|P-value:2.87E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.74|P-value:1.68E-6 ID:SGTC_2712|Compound:st079126|FD-Score:-3.42|P-value:4.05E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.50|P-value:2.58E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.37|P-value:4.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.09|P-value:3.03E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.12|P-value:9.71E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.52|P-value:2.40E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:5.20|P-value:1.33E-7 ID:SGTC_183|Compound:3914-0051|FD-Score:4.05|P-value:2.96E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:5.12|P-value:1.95E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.09|P-value:2.99E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.35|P-value:5.80E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:4.31|P-value:9.59E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.57|P-value:2.95E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:5.14|P-value:1.75E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:3.97|P-value:4.15E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.49|P-value:4.25E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.67|P-value:1.81E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.35|P-value:4.39E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.35|P-value:4.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.92|P-value:6.02E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.07|P-value:2.77E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.78|P-value:8.91E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.74|P-value:1.02E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.18|P-value:7.85E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.27|P-value:5.82E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.16|P-value:8.41E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.41|P-value:3.58E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.29|P-value:6.44E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.82|P-value:7.59E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.36|P-value:5.05E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.12|P-value:9.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.96|P-value:5.21E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.40|P-value:6.41E-6 ID:SGTC_2368|Compound:9071271|FD-Score:5.22|P-value:1.20E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.39|P-value:4.51E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-4.11|P-value:2.87E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.74|P-value:1.68E-6 ID:SGTC_2712|Compound:st079126|FD-Score:-3.42|P-value:4.05E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.50|P-value:2.58E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.37|P-value:4.10E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.09|P-value:3.03E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.12|P-value:9.71E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.52|P-value:2.40E-4

Top fitness defect scores for YIL096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_436 n,n-dimethylsphingosine 5.35 3.3 µM 5.80E-8 9 4.35E-8
2 SGTC_2368 9071271 5.22 200.0 µM 1.20E-7 8 9.17E-8
3 SGTC_135 0933-0004 5.20 26.4 µM 1.33E-7 60S ribosome export 8 1.02E-7
4 SGTC_651 3253-0966 5.14 34.4 µM 1.75E-7 calcium & mitochondrial duress 13 1.35E-7
5 SGTC_235 0330-0087 5.12 5.0 mM 1.95E-7 TSC3-RPN4 7 1.51E-7
6 SGTC_1033 k072-0102 4.67 21.3 µM 1.81E-6 60S ribosome export 7 1.47E-6
7 SGTC_565 1418-0001 4.57 44.5 µM 2.95E-6 7 2.43E-6
8 SGTC_942 3253-1115 4.49 227.0 µM 4.25E-6 16 3.53E-6
9 SGTC_2311 7694451 4.40 200.0 µM 6.41E-6 9 5.38E-6
10 SGTC_513 4245-1575 4.31 41.7 µM 9.59E-6 unfolded protein response 98 8.11E-6
11 SGTC_1446 4239-0190 4.07 62.0 µM 2.77E-5 33 2.40E-5
12 SGTC_183 3914-0051 4.05 30.6 µM 2.96E-5 60S ribosome export 21 2.57E-5
13 SGTC_890 0929-0006 3.97 47.2 µM 4.15E-5 17 3.63E-5
14 SGTC_2042 p-Dimethylaminoacetophenone 3.82 200.0 µM 7.59E-5 21 6.72E-5
15 SGTC_1562 morin hydrate 3.78 59.1 µM 8.91E-5 19 7.91E-5
16 SGTC_1565 sinapyl alcohol 3.74 95.1 µM 1.02E-4 36 9.11E-5
17 SGTC_2044 5102272 3.54 200.0 µM 2.18E-4 20 1.97E-4
18 SGTC_3252 9135871 3.52 49.5 µM 2.40E-4 21 2.18E-4
19 SGTC_2902 5787006 3.50 60.5 µM 2.58E-4 Golgi 39 2.35E-4
20 SGTC_2651 1327-0036 3.42 5.0 µM 3.40E-4 206 3.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.33E-9 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.090 1.64E-7 YPR003C_p YPR003C_p hom Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
0.087 3.90E-7 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.087 4.23E-7 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.086 6.08E-7 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.085 7.91E-7 YOL068C HST1 hom NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.085 8.25E-7 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.084 1.16E-6 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.082 2.20E-6 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.081 2.79E-6 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.081 2.98E-6 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.079 4.12E-6 YIL119C RPI1 hom Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.078 6.30E-6 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.074 1.58E-5 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.072 2.65E-5 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly