YIL103W / DPH1

Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL103W / DPH1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:3.72E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:4.11|P-value:4.44E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-8.74|P-value:1.65E-16 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.75|P-value:5.15E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.16|P-value:8.15E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.40|P-value:5.70E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.48|P-value:4.37E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.68|P-value:2.24E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.01|P-value:1.61E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.39|P-value:8.67E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.57|P-value:4.70E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.76|P-value:1.66E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.17|P-value:3.51E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.87|P-value:3.05E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.76|P-value:2.48E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.41|P-value:8.08E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.49|P-value:4.29E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.11|P-value:6.81E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:5.95|P-value:8.07E-9 ID:SGTC_851|Compound:0394-0702|FD-Score:3.58|P-value:3.15E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:5.95|P-value:8.11E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:8.56|P-value:2.77E-16 ID:SGTC_959|Compound:1222-0044|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.47|P-value:1.65E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.03|P-value:9.44E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.37|P-value:9.16E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.83|P-value:1.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-5.41|P-value:2.42E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.51|P-value:8.90E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.83|P-value:1.31E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.21|P-value:3.03E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.27|P-value:8.78E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-5.39|P-value:2.67E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.51|P-value:4.00E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.85|P-value:1.99E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.85|P-value:2.02E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.73|P-value:1.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.92|P-value:9.43E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_2283|Compound:7944793|FD-Score:6.02|P-value:5.72E-9 ID:SGTC_2390|Compound:9097792|FD-Score:3.58|P-value:3.15E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.55|P-value:3.53E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-4.27|P-value:3.72E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.40|P-value:5.73E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.12|P-value:4.30E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.61|P-value:4.90E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.93|P-value:9.13E-9 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.16|P-value:2.54E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.66|P-value:2.37E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.98|P-value:7.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.96|P-value:1.21E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.49|P-value:6.27E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.17|P-value:5.46E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.82|P-value:1.33E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.17|P-value:3.59E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.89|P-value:1.54E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.24|P-value:9.65E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:3.72E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:4.11|P-value:4.44E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-8.74|P-value:1.65E-16 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.75|P-value:5.15E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.16|P-value:8.15E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.40|P-value:5.70E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.48|P-value:4.37E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.68|P-value:2.24E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.01|P-value:1.61E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.39|P-value:8.67E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.57|P-value:4.70E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.76|P-value:1.66E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.17|P-value:3.51E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.87|P-value:3.05E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.76|P-value:2.48E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.41|P-value:8.08E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.49|P-value:4.29E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.11|P-value:6.81E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:5.95|P-value:8.07E-9 ID:SGTC_851|Compound:0394-0702|FD-Score:3.58|P-value:3.15E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:5.95|P-value:8.11E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:8.56|P-value:2.77E-16 ID:SGTC_959|Compound:1222-0044|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.47|P-value:1.65E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.03|P-value:9.44E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.37|P-value:9.16E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.83|P-value:1.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-5.41|P-value:2.42E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.51|P-value:8.90E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.83|P-value:1.31E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.21|P-value:3.03E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.27|P-value:8.78E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-5.39|P-value:2.67E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.51|P-value:4.00E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.85|P-value:1.99E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.85|P-value:2.02E-6 ID:SGTC_1859|Compound:st055998|FD-Score:3.73|P-value:1.88E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.92|P-value:9.43E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_2283|Compound:7944793|FD-Score:6.02|P-value:5.72E-9 ID:SGTC_2390|Compound:9097792|FD-Score:3.58|P-value:3.15E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.55|P-value:3.53E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-4.27|P-value:3.72E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.40|P-value:5.73E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.12|P-value:4.30E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.61|P-value:4.90E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.93|P-value:9.13E-9 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.16|P-value:2.54E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.66|P-value:2.37E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.98|P-value:7.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.96|P-value:1.21E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.49|P-value:6.27E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.17|P-value:5.46E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.82|P-value:1.33E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.17|P-value:3.59E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.89|P-value:1.54E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.24|P-value:9.65E-4

Top fitness defect scores for YIL103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_955 1216-0110 8.56 33.0 µM 2.77E-16 sphingolipid biosynthesis & PDR1 18 5.68E-18
2 SGTC_2567 aureobasidin a 6.16 60.0 nM 2.54E-9 41 3.61E-10
3 SGTC_2283 7944793 6.02 200.0 µM 5.72E-9 7 8.95E-10
4 SGTC_838 0109-0203 5.95 71.4 µM 8.07E-9 1 1.31E-9
5 SGTC_859 0439-0102 5.95 54.6 µM 8.11E-9 redox potentiating 5 1.32E-9
6 SGTC_2541 muurolladie-3-one 5.93 83.1 µM 9.13E-9 excess fatty acid 5 1.51E-9
7 SGTC_2540 epiandrosterone 5.61 100.0 µM 4.90E-8 22 9.87E-9
8 SGTC_1785 bathophenanthroline 4.85 24.0 µM 1.99E-6 heme requiring 24 6.16E-7
9 SGTC_1844 rapamycin 4.85 4.0 nM 2.02E-6 119 6.25E-7
10 SGTC_1418 3966-3099 4.51 2.4 µM 8.90E-6 12 3.26E-6
11 SGTC_1474 0330-0125 4.21 5.3 µM 3.03E-5 25 1.28E-5
12 SGTC_422 cantharidin 4.17 155.0 µM 3.51E-5 cell wall signaling 50 1.50E-5
13 SGTC_3094 9117742 4.17 49.5 µM 3.59E-5 15 1.54E-5
14 SGTC_2439 5492030 4.12 7.2 µM 4.30E-5 8 1.88E-5
15 SGTC_66 0109-0187 4.11 42.4 µM 4.44E-5 34 1.95E-5
16 SGTC_2701 st077767 3.98 14.7 µM 7.29E-5 43 3.38E-5
17 SGTC_1941 st076221 3.92 61.8 µM 9.43E-5 sphingolipid biosynthesis & PDR1 82 4.50E-5
18 SGTC_969 1313-0238 3.83 134.0 µM 1.31E-4 mitochondrial processes 30 6.46E-5
19 SGTC_1426 4048-4480 3.83 71.7 µM 1.31E-4 60S ribosome export 20 6.49E-5
20 SGTC_3075 9116269 3.82 49.5 µM 1.33E-4 24 6.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.39E-20 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.146 1.60E-17 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.134 8.08E-15 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.132 1.49E-14 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.131 2.18E-14 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.123 7.69E-13 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.121 2.09E-12 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.120 3.01E-12 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.117 9.13E-12 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.115 2.05E-11 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.111 1.27E-10 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.109 2.52E-10 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.106 6.27E-10 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.106 8.73E-10 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.105 9.44E-10 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress