YIL104C / SHQ1

Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL104C / SHQ1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:4.24|P-value:5.04E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.30|P-value:3.80E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:7.55|P-value:2.41E-15 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_510|Compound:ag-490|FD-Score:-3.33|P-value:3.35E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.68|P-value:5.67E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.40|P-value:1.47E-18 ID:SGTC_773|Compound:4358-1457|FD-Score:5.12|P-value:4.98E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.05|P-value:9.24E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:4.28E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.03|P-value:7.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.26|P-value:3.30E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.06|P-value:6.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.55|P-value:5.44E-12 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.98|P-value:1.68E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.03|P-value:9.90E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.18|P-value:6.78E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.18|P-value:4.43E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.55|P-value:1.42E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.20|P-value:2.98E-26 ID:SGTC_1749|Compound:st037932|FD-Score:-3.47|P-value:1.97E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.50|P-value:1.74E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.07|P-value:1.59E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.66|P-value:9.28E-5 ID:SGTC_2132|Compound:5317594|FD-Score:5.17|P-value:3.87E-8 ID:SGTC_2133|Compound:5320837|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.14|P-value:5.15E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.96|P-value:9.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.25|P-value:3.41E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.58|P-value:9.48E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:6.15E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.15|P-value:6.56E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.90|P-value:2.48E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.14|P-value:1.14E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.84|P-value:4.25E-5 ID:SGTC_3295|Compound:9122362|FD-Score:6.59|P-value:3.87E-12 ID:SGTC_3296|Compound:9122258|FD-Score:3.53|P-value:1.15E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.29|P-value:3.95E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:4.24|P-value:5.04E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.30|P-value:3.80E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:7.55|P-value:2.41E-15 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_510|Compound:ag-490|FD-Score:-3.33|P-value:3.35E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.68|P-value:5.67E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.40|P-value:1.47E-18 ID:SGTC_773|Compound:4358-1457|FD-Score:5.12|P-value:4.98E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.05|P-value:9.24E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:4.28E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.03|P-value:7.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.26|P-value:3.30E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.06|P-value:6.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.55|P-value:5.44E-12 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.98|P-value:1.68E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.03|P-value:9.90E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.18|P-value:6.78E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.18|P-value:4.43E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.55|P-value:1.42E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.20|P-value:2.98E-26 ID:SGTC_1749|Compound:st037932|FD-Score:-3.47|P-value:1.97E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.50|P-value:1.74E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.07|P-value:1.59E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.66|P-value:9.28E-5 ID:SGTC_2132|Compound:5317594|FD-Score:5.17|P-value:3.87E-8 ID:SGTC_2133|Compound:5320837|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.14|P-value:5.15E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.96|P-value:9.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.25|P-value:3.41E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.58|P-value:9.48E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:6.15E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.15|P-value:6.56E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.90|P-value:2.48E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.14|P-value:1.14E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.84|P-value:4.25E-5 ID:SGTC_3295|Compound:9122362|FD-Score:6.59|P-value:3.87E-12 ID:SGTC_3296|Compound:9122258|FD-Score:3.53|P-value:1.15E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.29|P-value:3.95E-4

Top fitness defect scores for YIL104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1745 st081495 10.20 74.0 µM 2.98E-26 RNA processing & uracil transport 2 1.36E-24 0.07
2 SGTC_682 0kpi-0099 8.40 17.0 µM 1.47E-18 7 2.14E-17 0.51
3 SGTC_376 3970-0862 7.55 59.1 µM 2.41E-15 2 2.17E-14 1.76
4 SGTC_3295 9122362 6.59 53.6 µM 3.87E-12 1 2.16E-11 0.91
5 SGTC_1173 0443-0020 6.55 122.0 µM 5.44E-12 TSC3-RPN4 1 2.96E-11 1.87
6 SGTC_2132 5317594 5.17 122.7 µM 3.87E-8 SWF1 & branched chain AA biosynthesis 2 1.18E-7 0.12
7 SGTC_773 4358-1457 5.12 44.6 µM 4.98E-8 7 1.49E-7 0.77
8 SGTC_673 1082-0474 4.68 110.0 µM 5.67E-7 RSC complex & mRNA processing 43 1.44E-6 0.15
9 SGTC_2615 purpurogallin-4-carboxylic acid 4.58 100.0 µM 9.48E-7 redox potentiating 3 2.33E-6 0.09
10 SGTC_928 2764-0428 4.28 58.7 µM 4.28E-6 cell wall 17 9.53E-6 0.25
11 SGTC_38 0929-0051 4.24 58.3 µM 5.04E-6 3 1.11E-5 0.01
12 SGTC_1277 0873-0036 4.18 22.0 µM 6.78E-6 PDR1 2 1.47E-5 0.20
13 SGTC_1213 1315-0166 3.98 115.0 µM 1.68E-5 14 3.41E-5 0.02
14 SGTC_2942 9052777 3.90 62.2 µM 2.48E-5 8 4.91E-5 0.05
15 SGTC_3296 9122258 3.53 64.0 µM 1.15E-4 redox potentiating 10 2.06E-4 0.04
16 SGTC_1419 3993-2473 3.44 62.6 µM 1.67E-4 9 2.91E-4 0.04
17 SGTC_829 1635-0120 3.35 117.0 µM 2.40E-4 DNA damage response 56 4.09E-4 0.01
18 SGTC_1628 st004252 3.34 77.7 µM 2.48E-4 10 4.22E-4 0.06
19 SGTC_1699 st031318 3.33 29.1 µM 2.53E-4 4 4.30E-4 0.03
20 SGTC_2612 dictamnine 3.28 15.5 µM 3.10E-4 RNA pol III & RNase P/MRP 40 5.20E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 2.07E-44 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.176 1.31E-24 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.148 6.98E-18 YLR277C YSH1 het Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication
0.137 1.35E-15 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.137 1.73E-15 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.128 8.96E-14 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.126 2.77E-13 YKL112W ABF1 het DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.124 5.43E-13 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.120 3.35E-12 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.119 3.93E-12 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.118 8.39E-12 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.117 1.29E-11 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.116 1.65E-11 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.112 6.77E-11 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.111 1.26E-10 YLR053C_p YLR053C_p hom Putative protein of unknown function