YIL106W / MOB1

Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL106W / MOB1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.03|P-value:3.67E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.99|P-value:4.77E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:3.43|P-value:3.71E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.40|P-value:9.19E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.03|P-value:3.76E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:5.52|P-value:2.89E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:6.09|P-value:1.11E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:3.17|P-value:8.90E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.26|P-value:6.57E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.94|P-value:5.29E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.07|P-value:3.19E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.41|P-value:4.46E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.54|P-value:4.05E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.25|P-value:6.96E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.43|P-value:6.66E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.10|P-value:1.03E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.20|P-value:9.20E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.30|P-value:5.84E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.53|P-value:4.26E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.24|P-value:7.12E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.84|P-value:7.97E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.31|P-value:5.62E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.99|P-value:4.34E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.72|P-value:1.73E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.36|P-value:4.69E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:8.68E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.11|P-value:2.67E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.87|P-value:7.17E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.59|P-value:2.07E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.43|P-value:6.69E-6 ID:SGTC_2347|Compound:9049783|FD-Score:-3.19|P-value:9.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.20|P-value:9.21E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.12|P-value:2.50E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.88|P-value:7.86E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.00|P-value:4.20E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.16|P-value:9.37E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.50|P-value:4.95E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.76|P-value:1.26E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.52|P-value:3.10E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.07|P-value:3.74E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.72|P-value:2.11E-11 ID:SGTC_2785|Compound:7756463|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.33|P-value:5.89E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.25|P-value:7.72E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.28|P-value:6.24E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.20|P-value:1.80E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.21|P-value:7.93E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.71|P-value:1.30E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.54|P-value:4.13E-6 ID:SGTC_3117|Compound:9124945|FD-Score:3.49|P-value:2.93E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.20|P-value:9.34E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.87|P-value:6.94E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.20|P-value:9.14E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.34|P-value:5.70E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.03|P-value:3.67E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.99|P-value:4.77E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:3.43|P-value:3.71E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.40|P-value:9.19E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.03|P-value:3.76E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:5.52|P-value:2.89E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:6.09|P-value:1.11E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:3.17|P-value:8.90E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.26|P-value:6.57E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.94|P-value:5.29E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.07|P-value:3.19E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.41|P-value:4.46E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.54|P-value:4.05E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.25|P-value:6.96E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.43|P-value:6.66E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.10|P-value:1.03E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.20|P-value:9.20E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.30|P-value:5.84E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.53|P-value:4.26E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.24|P-value:7.12E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.84|P-value:7.97E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.31|P-value:5.62E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.99|P-value:4.34E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.72|P-value:1.73E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.36|P-value:4.69E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:8.68E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.11|P-value:2.67E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.87|P-value:7.17E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.59|P-value:2.07E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.43|P-value:6.69E-6 ID:SGTC_2347|Compound:9049783|FD-Score:-3.19|P-value:9.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.20|P-value:9.21E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.12|P-value:2.50E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.88|P-value:7.86E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.00|P-value:4.20E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.16|P-value:9.37E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.50|P-value:4.95E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.76|P-value:1.26E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.52|P-value:3.10E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.07|P-value:3.74E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.72|P-value:2.11E-11 ID:SGTC_2785|Compound:7756463|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.33|P-value:5.89E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.25|P-value:7.72E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.28|P-value:6.24E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.20|P-value:1.80E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.21|P-value:7.93E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.71|P-value:1.30E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.54|P-value:4.13E-6 ID:SGTC_3117|Compound:9124945|FD-Score:3.49|P-value:2.93E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.20|P-value:9.34E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.87|P-value:6.94E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.20|P-value:9.14E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.34|P-value:5.70E-4

Top fitness defect scores for YIL106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2619 obliquin 6.72 87.9 µM 2.11E-11 cell wall 12 9.12E-12 0.47
2 SGTC_1133 3473-0247 6.10 50.0 µM 1.03E-9 RSC complex & mRNA processing 21 5.18E-10 0.03
3 SGTC_514 4466-0038 6.09 2.6 nM 1.11E-9 cell wall 15 5.61E-10 0.01
4 SGTC_268 camptothecin 5.52 39.6 µM 2.89E-8 DNA damage response 26 1.66E-8 0.18
5 SGTC_2396 5342950 5.12 42.8 µM 2.50E-7 RSC complex & mRNA processing 18 1.56E-7 0.21
6 SGTC_157 1348-1695 4.99 65.8 µM 4.77E-7 iron homeostasis 24 3.06E-7 0.50
7 SGTC_1739 st037196 4.72 92.5 µM 1.73E-6 1 1.17E-6 0.55
8 SGTC_839 0122-0028 4.54 230.0 µM 4.05E-6 RSC complex & mRNA processing 26 2.82E-6 0.02
9 SGTC_3012 9080433 4.54 71.4 µM 4.13E-6 1 2.88E-6 0.80
10 SGTC_1206 3978-0017 4.53 132.0 µM 4.26E-6 ERG2 3 2.97E-6 0.21
11 SGTC_2544 sphondin 4.50 68.5 µM 4.95E-6 RNA pol III & RNase P/MRP 31 3.47E-6 0.04
12 SGTC_1120 ficusin 4.43 1.8 µM 6.66E-6 2 4.72E-6 0.51
13 SGTC_2336 9001819 4.43 198.7 µM 6.69E-6 heme biosynthesis & mitochondrial translocase 32 4.74E-6 0.07
14 SGTC_2928 9011484 4.20 9.8 µM 1.80E-5 heme biosynthesis & mitochondrial translocase 27 1.32E-5 0.01
15 SGTC_2157 5649910 4.11 96.4 µM 2.67E-5 5 1.99E-5 0.07
16 SGTC_2785 7756463 4.09 72.7 µM 2.85E-5 16 2.13E-5 0.13
17 SGTC_772 k072-0172 4.07 35.3 µM 3.19E-5 2 2.40E-5 0.35
18 SGTC_10 0279-0212 4.03 42.6 µM 3.67E-5 TRP & mitochondrial translation 7 2.77E-5 0.37
19 SGTC_184 1494-0393 4.03 24.7 µM 3.76E-5 29 2.84E-5 0.05
20 SGTC_2488 5268135 4.00 45.7 µM 4.20E-5 7 3.19E-5 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 1.75E-44 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.233 1.70E-42 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.224 1.39E-39 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.210 6.72E-35 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.208 3.08E-34 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.204 9.43E-33 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.195 4.07E-30 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.181 3.56E-26 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.176 1.20E-24 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.173 4.54E-24 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.170 3.86E-23 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.164 9.48E-22 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.158 2.73E-20 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.158 4.44E-20 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.153 5.84E-19 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p