YIL107C / PFK26

6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL107C / PFK26

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:13.10|P-value:2.30E-35 ID:SGTC_161|Compound:4065-0411|FD-Score:4.26|P-value:2.78E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.35|P-value:2.15E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:1.96E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:8.36|P-value:1.53E-15 ID:SGTC_740|Compound:k014-0057|FD-Score:5.00|P-value:1.17E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:5.38|P-value:1.90E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:3.32|P-value:8.33E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-5.06|P-value:1.02E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.80|P-value:3.36E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:5.24|P-value:3.68E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:4.21|P-value:3.48E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:32.10|P-value:2.55E-201 ID:SGTC_1571|Compound:st070080|FD-Score:3.31|P-value:8.63E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.99|P-value:9.25E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.38|P-value:7.70E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.45|P-value:6.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.32|P-value:2.22E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.45|P-value:5.49E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.49|P-value:4.88E-4 ID:SGTC_2040|Compound:5100729|FD-Score:10.40|P-value:3.92E-23 ID:SGTC_2054|Compound:5233173|FD-Score:7.58|P-value:4.26E-13 ID:SGTC_2061|Compound:5245884|FD-Score:5.11|P-value:6.79E-7 ID:SGTC_2090|Compound:5301565|FD-Score:-3.63|P-value:3.32E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.84|P-value:1.41E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.44|P-value:5.75E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.00|P-value:7.73E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.57|P-value:4.03E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.44|P-value:1.35E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.60|P-value:8.71E-33 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.58|P-value:8.68E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.89|P-value:1.31E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.53|P-value:1.03E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.40|P-value:3.86E-23 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.37|P-value:7.87E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.00|P-value:1.16E-6 ID:SGTC_2646|Compound:retinol|FD-Score:4.10|P-value:5.33E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:3.45E-38 ID:SGTC_2688|Compound:kanamycin b|FD-Score:17.80|P-value:2.07E-63 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.51|P-value:5.02E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.40|P-value:6.49E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.54|P-value:4.51E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.09|P-value:7.74E-7 ID:SGTC_3139|Compound:9095020|FD-Score:4.58|P-value:7.51E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.33|P-value:8.12E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.72|P-value:2.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:13.10|P-value:2.30E-35 ID:SGTC_161|Compound:4065-0411|FD-Score:4.26|P-value:2.78E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.35|P-value:2.15E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:1.96E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:8.36|P-value:1.53E-15 ID:SGTC_740|Compound:k014-0057|FD-Score:5.00|P-value:1.17E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:5.38|P-value:1.90E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:3.32|P-value:8.33E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-5.06|P-value:1.02E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.80|P-value:3.36E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:5.24|P-value:3.68E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:4.21|P-value:3.48E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:32.10|P-value:2.55E-201 ID:SGTC_1571|Compound:st070080|FD-Score:3.31|P-value:8.63E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.99|P-value:9.25E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.38|P-value:7.70E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.45|P-value:6.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.32|P-value:2.22E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.45|P-value:5.49E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.49|P-value:4.88E-4 ID:SGTC_2040|Compound:5100729|FD-Score:10.40|P-value:3.92E-23 ID:SGTC_2054|Compound:5233173|FD-Score:7.58|P-value:4.26E-13 ID:SGTC_2061|Compound:5245884|FD-Score:5.11|P-value:6.79E-7 ID:SGTC_2090|Compound:5301565|FD-Score:-3.63|P-value:3.32E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.84|P-value:1.41E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.44|P-value:5.75E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.00|P-value:7.73E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.57|P-value:4.03E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.44|P-value:1.35E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.60|P-value:8.71E-33 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.58|P-value:8.68E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.89|P-value:1.31E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.53|P-value:1.03E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.40|P-value:3.86E-23 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.37|P-value:7.87E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.00|P-value:1.16E-6 ID:SGTC_2646|Compound:retinol|FD-Score:4.10|P-value:5.33E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:3.45E-38 ID:SGTC_2688|Compound:kanamycin b|FD-Score:17.80|P-value:2.07E-63 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.51|P-value:5.02E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.40|P-value:6.49E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.54|P-value:4.51E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.09|P-value:7.74E-7 ID:SGTC_3139|Compound:9095020|FD-Score:4.58|P-value:7.51E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.33|P-value:8.12E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.72|P-value:2.45E-4

Top fitness defect scores for YIL107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1309 pyrazolanthrone 32.10 13.4 µM 2.55E-201 1 1.79E-226
2 SGTC_2688 kanamycin b 17.80 96.7 µM 2.07E-63 calcium & mitochondrial duress 3 4.21E-71
3 SGTC_2651 1327-0036 13.60 5.0 µM 3.45E-38 10 1.05E-42
4 SGTC_58 0957-0393 13.10 9.0 µM 2.30E-35 cell wall 38 1.59E-39
5 SGTC_2582 agaric acid 12.60 100.0 µM 8.71E-33 redox potentiating 33 1.26E-36
6 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 10.40 100.0 µM 3.86E-23 1 8.98E-26
7 SGTC_2040 5100729 10.40 123.0 µM 3.92E-23 2 9.14E-26
8 SGTC_650 1328-0195 8.36 38.0 µM 1.53E-15 2 3.13E-17
9 SGTC_2054 5233173 7.58 129.0 µM 4.26E-13 mitochondrial response to ROS 7 1.74E-14
10 SGTC_829 1635-0120 5.38 117.0 µM 1.90E-7 DNA damage response 13 3.78E-8
11 SGTC_266 formosanin C 5.35 406.0 nM 2.15E-7 sphingolipid biosynthesis & PDR1 39 4.34E-8
12 SGTC_963 1269-2853 5.24 151.0 µM 3.68E-7 10 7.95E-8
13 SGTC_2061 5245884 5.11 81.0 µM 6.79E-7 tubulin folding & SWR complex 10 1.58E-7
14 SGTC_3137 9097352 5.09 49.5 µM 7.74E-7 16 1.83E-7
15 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 5.00 100.0 µM 1.16E-6 8 2.88E-7
16 SGTC_740 k014-0057 5.00 261.0 µM 1.17E-6 7 2.90E-7
17 SGTC_3139 9095020 4.58 49.5 µM 7.51E-6 2 2.32E-6
18 SGTC_2410 aloe-emodin-8-o-glycoside 4.44 46.3 µM 1.35E-5 mitochondrial processes 16 4.47E-6
19 SGTC_1712 st032288 4.32 53.4 µM 2.22E-5 calcium & mitochondrial duress 164 7.83E-6
20 SGTC_161 4065-0411 4.26 162.2 µM 2.78E-5 54 1.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.439 4.14E-158 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.385 6.75E-119 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.373 5.27E-111 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.359 7.91E-103 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.351 6.41E-98 YIL124W AYR1 hom NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
0.297 1.67E-69 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.289 2.08E-65 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.259 1.87E-52 YIL097W FYV10 hom Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.231 9.40E-42 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.229 5.24E-41 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.227 2.77E-40 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.226 3.07E-40 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.221 2.80E-38 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.206 1.55E-33 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.194 7.95E-30 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress