YIL109C / SEC24

Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL109C / SEC24

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:2.91|P-value:4.39E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:2.80|P-value:6.65E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.75|P-value:8.04E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.76|P-value:8.75E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.13|P-value:1.22E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:2.74|P-value:8.43E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.88|P-value:4.61E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.60|P-value:1.92E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.18|P-value:9.19E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:2.94|P-value:3.85E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:7.38|P-value:2.18E-17 ID:SGTC_290|Compound:2043-6722|FD-Score:2.93|P-value:3.97E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.77|P-value:7.45E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.72|P-value:9.23E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.50|P-value:3.10E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:6.86|P-value:2.75E-15 ID:SGTC_384|Compound:k007-0144|FD-Score:2.88|P-value:4.81E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.63|P-value:6.51E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:5.94|P-value:6.26E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:3.12|P-value:1.82E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:6.80|P-value:4.80E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:2.91|P-value:4.27E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.93|P-value:3.65E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:-2.97|P-value:4.15E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.46|P-value:1.82E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.20|P-value:1.26E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.18|P-value:1.37E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.03|P-value:2.65E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.22|P-value:1.35E-9 ID:SGTC_790|Compound:1575-0012|FD-Score:2.72|P-value:9.19E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.78|P-value:7.29E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.82|P-value:6.10E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.84|P-value:5.76E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.14|P-value:1.65E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.57|P-value:2.22E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.03|P-value:4.80E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.53|P-value:2.71E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.41|P-value:4.82E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.19|P-value:1.34E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.66|P-value:5.26E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.29|P-value:8.27E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.95|P-value:3.74E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.76|P-value:8.77E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.95|P-value:3.61E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.31|P-value:7.63E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.76|P-value:9.34E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.11|P-value:1.87E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.72|P-value:1.06E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-5.90|P-value:1.28E-11 ID:SGTC_1876|Compound:myriocin|FD-Score:3.30|P-value:8.10E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.94|P-value:3.87E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.40|P-value:5.12E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.02|P-value:2.78E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.65|P-value:5.47E-8 ID:SGTC_2159|Compound:5658611|FD-Score:3.89|P-value:4.34E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.95|P-value:4.53E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.70|P-value:3.50E-34 ID:SGTC_2316|Compound:5844804|FD-Score:3.51|P-value:3.08E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.22|P-value:1.16E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.06|P-value:2.30E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.12|P-value:2.24E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.73|P-value:8.78E-4 ID:SGTC_2461|Compound:5755302|FD-Score:5.22|P-value:1.32E-9 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.25|P-value:9.94E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.60|P-value:2.40E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.52|P-value:3.56E-5 ID:SGTC_2602|Compound:kawain|FD-Score:2.72|P-value:9.26E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:7.00|P-value:7.94E-16 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:1.06E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:1.32E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.71|P-value:8.38E-19 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.03|P-value:3.24E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.16|P-value:1.88E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.60|P-value:1.90E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.41|P-value:2.40E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.39|P-value:6.72E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.91|P-value:4.39E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:2.80|P-value:6.65E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.75|P-value:8.04E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.76|P-value:8.75E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.13|P-value:1.22E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:2.74|P-value:8.43E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.88|P-value:4.61E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.60|P-value:1.92E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.18|P-value:9.19E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:2.94|P-value:3.85E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:7.38|P-value:2.18E-17 ID:SGTC_290|Compound:2043-6722|FD-Score:2.93|P-value:3.97E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.77|P-value:7.45E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.72|P-value:9.23E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.50|P-value:3.10E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:6.86|P-value:2.75E-15 ID:SGTC_384|Compound:k007-0144|FD-Score:2.88|P-value:4.81E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.63|P-value:6.51E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:5.94|P-value:6.26E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:3.12|P-value:1.82E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:6.80|P-value:4.80E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:2.91|P-value:4.27E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.93|P-value:3.65E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:-2.97|P-value:4.15E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.46|P-value:1.82E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.20|P-value:1.26E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.18|P-value:1.37E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.03|P-value:2.65E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.22|P-value:1.35E-9 ID:SGTC_790|Compound:1575-0012|FD-Score:2.72|P-value:9.19E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.78|P-value:7.29E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.82|P-value:6.10E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.84|P-value:5.76E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.14|P-value:1.65E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.57|P-value:2.22E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.03|P-value:4.80E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.53|P-value:2.71E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.41|P-value:4.82E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.19|P-value:1.34E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.66|P-value:5.26E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.29|P-value:8.27E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.95|P-value:3.74E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.76|P-value:8.77E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.95|P-value:3.61E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.31|P-value:7.63E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.76|P-value:9.34E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.11|P-value:1.87E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.72|P-value:1.06E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-5.90|P-value:1.28E-11 ID:SGTC_1876|Compound:myriocin|FD-Score:3.30|P-value:8.10E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.94|P-value:3.87E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.40|P-value:5.12E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.02|P-value:2.78E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.65|P-value:5.47E-8 ID:SGTC_2159|Compound:5658611|FD-Score:3.89|P-value:4.34E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.95|P-value:4.53E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.70|P-value:3.50E-34 ID:SGTC_2316|Compound:5844804|FD-Score:3.51|P-value:3.08E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.22|P-value:1.16E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.06|P-value:2.30E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.12|P-value:2.24E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.73|P-value:8.78E-4 ID:SGTC_2461|Compound:5755302|FD-Score:5.22|P-value:1.32E-9 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.25|P-value:9.94E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.60|P-value:2.40E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.52|P-value:3.56E-5 ID:SGTC_2602|Compound:kawain|FD-Score:2.72|P-value:9.26E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:7.00|P-value:7.94E-16 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:1.06E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:1.32E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.71|P-value:8.38E-19 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.03|P-value:3.24E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.16|P-value:1.88E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.60|P-value:1.90E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.41|P-value:2.40E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.39|P-value:6.72E-5

Top fitness defect scores for YIL109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2249 haloperidol 10.70 116.4 µM 3.50E-34 ergosterol depletion effects on membrane 7 7.56E-27 2.66
2 SGTC_2756 carbadox 7.71 75.1 µM 8.38E-19 5 6.45E-15 0.46
3 SGTC_283 0987-0079 7.38 11.7 µM 2.18E-17 2 8.10E-14 2.91
4 SGTC_2645 abamectin 7.00 100.0 µM 7.94E-16 heme requiring 1 1.32E-12 0.68
5 SGTC_363 0455-0021 6.86 3.1 µM 2.75E-15 azole & statin 5 3.46E-12 0.54
6 SGTC_592 k241-0073 6.80 46.5 µM 4.80E-15 2 5.33E-12 2.40
7 SGTC_226 1,3-diallylurea 6.18 8.3 mM 9.19E-13 4 3.16E-10 1.40
8 SGTC_513 4245-1575 5.94 41.7 µM 6.26E-12 unfolded protein response 9 1.40E-9 0.11
9 SGTC_2461 5755302 5.22 26.1 µM 1.32E-9 1 9.00E-8 0.87
10 SGTC_786 4544-0069 5.22 423.0 µM 1.35E-9 4 9.18E-8 0.63
11 SGTC_917 harmaline 5.03 728.1 nM 4.80E-9 ergosterol biosynthesis 3 2.46E-7 0.26
12 SGTC_1161 k007-0610 4.66 110.0 µM 5.26E-8 ERAD & cell cycle 28 1.58E-6 0.00
13 SGTC_2158 5657123 4.65 3.6 µM 5.47E-8 9 1.63E-6 0.04
14 SGTC_451 chloral hydrate 4.63 100.0 µM 6.51E-8 12 1.87E-6 0.00
15 SGTC_682 0kpi-0099 4.46 17.0 µM 1.82E-7 24 4.17E-6 0.21
16 SGTC_3200 9114385 4.41 49.5 µM 2.40E-7 12 5.17E-6 0.04
17 SGTC_161 4065-0411 4.13 162.2 µM 1.22E-6 10 1.84E-5 0.49
18 SGTC_638 3970-0837 3.93 4.1 µM 3.65E-6 5 4.32E-5 0.23
19 SGTC_2159 5658611 3.89 73.8 µM 4.34E-6 6 4.95E-5 0.11
20 SGTC_188 3229-0966 3.88 278.5 µM 4.61E-6 19 5.18E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 3.52E-44 YLR208W SEC13 het Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
0.156 9.07E-20 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.148 7.15E-18 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.148 8.24E-18 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.125 3.73E-13 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.123 7.67E-13 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.121 2.15E-12 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.118 7.22E-12 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.114 3.57E-11 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.110 1.49E-10 YGL153W PEX14 hom Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
0.110 2.04E-10 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.110 2.02E-10 YDL195W SEC31 het Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
0.108 3.86E-10 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.107 6.02E-10 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.106 6.64E-10 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis