YIL110W / HPM1

AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL110W / HPM1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.03|P-value:7.23E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.89|P-value:1.25E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.29|P-value:3.38E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.25|P-value:3.11E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.61|P-value:4.87E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.68|P-value:2.60E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.87|P-value:1.31E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.08|P-value:9.14E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.62|P-value:5.45E-10 ID:SGTC_547|Compound:1120-0019|FD-Score:4.73|P-value:4.29E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:5.23|P-value:4.45E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.32|P-value:8.49E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.22|P-value:5.51E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:5.60|P-value:7.41E-8 ID:SGTC_606|Compound:k015-0008|FD-Score:-5.08|P-value:1.56E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.68|P-value:3.87E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.04|P-value:1.06E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.40|P-value:6.58E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.66|P-value:5.49E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:3.64|P-value:2.95E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.06|P-value:9.77E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.67|P-value:3.91E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:9.33E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.99|P-value:1.36E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.88|P-value:1.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.81|P-value:4.95E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.83|P-value:1.55E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.89|P-value:1.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.51|P-value:1.18E-7 ID:SGTC_1670|Compound:st016595|FD-Score:4.58|P-value:8.24E-6 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:7.14E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.38|P-value:7.12E-4 ID:SGTC_1971|Compound:st069429|FD-Score:5.17|P-value:6.12E-7 ID:SGTC_2082|Compound:5219693|FD-Score:-3.78|P-value:2.70E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.50|P-value:4.70E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.29|P-value:9.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.50|P-value:1.85E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.12|P-value:7.93E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.48|P-value:5.16E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.31|P-value:8.88E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.53|P-value:4.26E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.43|P-value:5.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.37|P-value:7.17E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.37|P-value:7.34E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.68|P-value:3.75E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.47|P-value:7.64E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.64|P-value:6.50E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:2.88E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.29|P-value:9.35E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.98|P-value:2.38E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-4.29|P-value:4.23E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.81|P-value:3.12E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:1.02E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.26|P-value:3.05E-5 ID:SGTC_3017|Compound:9080681|FD-Score:4.69|P-value:5.13E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-3.92|P-value:1.67E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.29|P-value:9.39E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.44|P-value:5.84E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-6.20|P-value:5.64E-9 ID:SGTC_3190|Compound:9110366|FD-Score:4.14|P-value:4.82E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.03|P-value:7.23E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.89|P-value:1.25E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.29|P-value:3.38E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.25|P-value:3.11E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.61|P-value:4.87E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.68|P-value:2.60E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.87|P-value:1.31E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.08|P-value:9.14E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.62|P-value:5.45E-10 ID:SGTC_547|Compound:1120-0019|FD-Score:4.73|P-value:4.29E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:5.23|P-value:4.45E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:3.32|P-value:8.49E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.22|P-value:5.51E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:5.60|P-value:7.41E-8 ID:SGTC_606|Compound:k015-0008|FD-Score:-5.08|P-value:1.56E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.68|P-value:3.87E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.04|P-value:1.06E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.40|P-value:6.58E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.66|P-value:5.49E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:3.64|P-value:2.95E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.06|P-value:9.77E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.67|P-value:3.91E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:9.33E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.99|P-value:1.36E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.88|P-value:1.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.81|P-value:4.95E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.83|P-value:1.55E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.89|P-value:1.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.51|P-value:1.18E-7 ID:SGTC_1670|Compound:st016595|FD-Score:4.58|P-value:8.24E-6 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:7.14E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.38|P-value:7.12E-4 ID:SGTC_1971|Compound:st069429|FD-Score:5.17|P-value:6.12E-7 ID:SGTC_2082|Compound:5219693|FD-Score:-3.78|P-value:2.70E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.50|P-value:4.70E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.29|P-value:9.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.50|P-value:1.85E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.12|P-value:7.93E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.48|P-value:5.16E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.31|P-value:8.88E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.53|P-value:4.26E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.43|P-value:5.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.37|P-value:7.17E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.37|P-value:7.34E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.68|P-value:3.75E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.47|P-value:7.64E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.64|P-value:6.50E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:2.88E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.29|P-value:9.35E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.98|P-value:2.38E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-4.29|P-value:4.23E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.81|P-value:3.12E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:1.02E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.26|P-value:3.05E-5 ID:SGTC_3017|Compound:9080681|FD-Score:4.69|P-value:5.13E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-3.92|P-value:1.67E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.29|P-value:9.39E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.44|P-value:5.84E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-6.20|P-value:5.64E-9 ID:SGTC_3190|Compound:9110366|FD-Score:4.14|P-value:4.82E-5

Top fitness defect scores for YIL110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 5.66 155.0 µM 5.49E-8 translation 62 7.64E-9
2 SGTC_598 3937-0236 5.60 20.2 µM 7.41E-8 ERG2 10 1.08E-8
3 SGTC_1635 st007035 5.51 42.4 µM 1.18E-7 146 1.84E-8
4 SGTC_150 3970-0969 5.29 77.2 µM 3.38E-7 32 6.08E-8
5 SGTC_558 k064-0027 5.23 21.3 µM 4.45E-7 DNA damage response 10 8.34E-8
6 SGTC_1971 st069429 5.17 63.5 µM 6.12E-7 60S ribosome export 4 1.20E-7
7 SGTC_451 chloral hydrate 5.08 100.0 µM 9.14E-7 26 1.89E-7
8 SGTC_881 0833-0569 5.06 170.0 µM 9.77E-7 5 2.04E-7
9 SGTC_1106 tegaserod maleate 4.99 11.7 µM 1.36E-6 3 2.97E-7
10 SGTC_2688 kanamycin b 4.82 96.7 µM 2.88E-6 calcium & mitochondrial duress 261 7.02E-7
11 SGTC_2907 7721985 4.81 69.9 µM 3.12E-6 6 7.67E-7
12 SGTC_547 1120-0019 4.73 610.0 nM 4.29E-6 azole & statin 19 1.10E-6
13 SGTC_3017 9080681 4.69 49.5 µM 5.13E-6 8 1.35E-6
14 SGTC_2555 cholic acid 4.64 100.0 µM 6.50E-6 11 1.77E-6
15 SGTC_1670 st016595 4.58 4.0 µM 8.24E-6 5 2.32E-6
16 SGTC_3002 9075603 4.26 71.4 µM 3.05E-5 13 1.03E-5
17 SGTC_245 methotrexate 4.25 289.6 µM 3.11E-5 37 1.05E-5
18 SGTC_3190 9110366 4.14 49.5 µM 4.82E-5 9 1.73E-5
19 SGTC_1746 st038117 4.04 42.0 µM 7.14E-5 31 2.71E-5
20 SGTC_81 0411-0046 4.03 10.0 µM 7.23E-5 23 2.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.19E-24 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.158 3.17E-20 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.145 2.76E-17 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.144 5.28E-17 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.141 2.36E-16 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.122 1.50E-12 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.120 3.58E-12 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.119 4.66E-12 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.113 5.87E-11 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.112 6.92E-11 YLR448W RPL6B hom Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
0.111 1.08E-10 YIL077C_p YIL077C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.111 1.27E-10 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.110 1.95E-10 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.108 2.95E-10 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.108 2.96E-10 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication