YIL111W / COX5B

Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL111W / COX5B

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.63|P-value:4.71E-9 ID:SGTC_80|Compound:0159-0065|FD-Score:4.98|P-value:1.85E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:4.10|P-value:1.41E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.13|P-value:8.80E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.71|P-value:7.55E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.21|P-value:6.53E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.70|P-value:7.73E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.75|P-value:6.41E-7 ID:SGTC_1689|Compound:st020265|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.03|P-value:9.61E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.97|P-value:2.48E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.58|P-value:1.05E-11 ID:SGTC_2979|Compound:9012552|FD-Score:-3.31|P-value:4.57E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.36|P-value:3.88E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.55|P-value:1.87E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.63|P-value:4.71E-9 ID:SGTC_80|Compound:0159-0065|FD-Score:4.98|P-value:1.85E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:4.10|P-value:1.41E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.13|P-value:8.80E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.71|P-value:7.55E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.11|P-value:7.25E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.21|P-value:6.53E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.70|P-value:7.73E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.75|P-value:6.41E-7 ID:SGTC_1689|Compound:st020265|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.03|P-value:9.61E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.97|P-value:2.48E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.58|P-value:1.05E-11 ID:SGTC_2979|Compound:9012552|FD-Score:-3.31|P-value:4.57E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.36|P-value:3.88E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.55|P-value:1.87E-4

Top fitness defect scores for YIL111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.58 100.0 µM 1.05E-11 redox potentiating 142 2.36E-11
2 SGTC_58 0957-0393 5.63 9.0 µM 4.71E-9 cell wall 232 8.83E-9
3 SGTC_80 0159-0065 4.98 512.2 µM 1.85E-7 1 3.11E-7
4 SGTC_1570 verbenone 4.75 133.0 µM 6.41E-7 6 1.04E-6
5 SGTC_435 c-PAF 4.71 6.7 µM 7.55E-7 18 1.22E-6
6 SGTC_116 0155-0182 4.10 31.8 µM 1.41E-5 mitochondrial response to ROS 69 2.08E-5
7 SGTC_2176 5809774 3.97 34.0 µM 2.48E-5 mitochondrial processes 10 3.59E-5
8 SGTC_1535 tetrahydropapaveroline hydrobromide 3.70 54.3 µM 7.73E-5 RPP1 & pyrimidine depletion 15 1.08E-4
9 SGTC_2184 6075246 3.55 200.0 µM 1.42E-4 38 1.95E-4
10 SGTC_1689 st020265 3.46 53.5 µM 1.97E-4 25 2.68E-4
11 SGTC_439 amiodarone 3.11 34.4 µM 7.25E-4 NEO1-PIK1 143 9.43E-4
12 SGTC_1877 wortmannin 3.03 25.0 µM 9.61E-4 143 0.00124
13 SGTC_2570 licareol 2.97 100.0 µM 0.00118 75 0.00151
14 SGTC_2420 aureobasidin a 2.96 50.0 nM 0.00121 102 0.00155
15 SGTC_1693 xanthone 2.93 101.9 µM 0.00135 DNA damage response 47 0.00172
16 SGTC_1248 0469-0687 2.91 58.6 µM 0.00144 87 0.00183
17 SGTC_1374 2889-5571 2.89 141.0 µM 0.00150 RSC complex & mRNA processing 106 0.00191
18 SGTC_1764 st044502 2.87 93.5 µM 0.00161 93 0.00204
19 SGTC_1759 st043059 2.84 70.0 µM 0.00177 amide catabolism 80 0.00224
20 SGTC_266 formosanin C 2.82 406.0 nM 0.00192 sphingolipid biosynthesis & PDR1 144 0.00242

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.394 6.14E-125 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.321 4.11E-81 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.293 1.55E-67 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.262 8.85E-54 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.258 2.38E-52 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.253 5.74E-50 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.248 4.44E-48 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.247 6.29E-48 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.237 4.90E-44 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.234 6.69E-43 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.229 5.04E-41 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.227 2.70E-40 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.225 8.36E-40 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.223 6.41E-39 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.221 1.60E-38 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane