YIL113W / SDP1

Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL113W / SDP1

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.36|P-value:4.13E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.22|P-value:9.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.58|P-value:4.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.45|P-value:4.09E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.73|P-value:1.50E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.38|P-value:1.05E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.64|P-value:2.11E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.73|P-value:1.50E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.63|P-value:2.06E-8 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.37|P-value:5.41E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.24|P-value:8.47E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.24|P-value:8.42E-4 ID:SGTC_1738|Compound:st035555|FD-Score:9.18|P-value:1.44E-19 ID:SGTC_1754|Compound:st042065|FD-Score:-3.64|P-value:1.44E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.92|P-value:7.22E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.10|P-value:3.41E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.30|P-value:7.02E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.31|P-value:6.67E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.03|P-value:4.50E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.42|P-value:8.83E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-5.91|P-value:2.52E-9 ID:SGTC_2204|Compound:7233102|FD-Score:3.30|P-value:6.93E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.27|P-value:7.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.61|P-value:1.62E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.21|P-value:9.35E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.78|P-value:1.21E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.35|P-value:5.92E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.65|P-value:2.02E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.58|P-value:1.87E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.44|P-value:3.13E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.12|P-value:3.12E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.17|P-value:2.54E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.23|P-value:8.86E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:5.44E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-3.41|P-value:3.40E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.97|P-value:3.93E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.36|P-value:4.13E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.22|P-value:9.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.58|P-value:4.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.45|P-value:4.09E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.73|P-value:1.50E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.38|P-value:1.05E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.64|P-value:2.11E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.73|P-value:1.50E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.63|P-value:2.06E-8 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.37|P-value:5.41E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.24|P-value:8.47E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.24|P-value:8.42E-4 ID:SGTC_1738|Compound:st035555|FD-Score:9.18|P-value:1.44E-19 ID:SGTC_1754|Compound:st042065|FD-Score:-3.64|P-value:1.44E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.92|P-value:7.22E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.10|P-value:3.41E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.30|P-value:7.02E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.31|P-value:6.67E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.03|P-value:4.50E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.42|P-value:8.83E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-5.91|P-value:2.52E-9 ID:SGTC_2204|Compound:7233102|FD-Score:3.30|P-value:6.93E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.42|P-value:4.64E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.27|P-value:7.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.61|P-value:1.62E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.21|P-value:9.35E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.78|P-value:1.21E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.35|P-value:5.92E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.65|P-value:2.02E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.58|P-value:1.87E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.25|P-value:6.08E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.44|P-value:3.13E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.12|P-value:3.12E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.17|P-value:2.54E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.23|P-value:8.86E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:5.44E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-3.41|P-value:3.40E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.97|P-value:3.93E-5

Top fitness defect scores for YIL113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1738 st035555 9.18 74.0 µM 1.44E-19 TSC3-RPN4 2 2.11E-20
2 SGTC_1344 1488-0097 5.63 29.1 µM 2.06E-8 3 8.92E-9
3 SGTC_874 0599-0792 4.58 117.0 µM 4.22E-6 14 2.31E-6
4 SGTC_2107 5363541 4.42 170.2 µM 8.83E-6 4 5.01E-6
5 SGTC_1144 3486-0183 4.38 12.5 µM 1.05E-5 17 5.97E-6
6 SGTC_3207 9114163 4.17 49.5 µM 2.54E-5 23 1.51E-5
7 SGTC_3202 9113761 4.12 49.5 µM 3.12E-5 43 1.87E-5
8 SGTC_1922 5578187 4.10 25.0 µM 3.41E-5 TRP & mitochondrial translation 25 2.06E-5
9 SGTC_2065 5221596 4.03 34.3 µM 4.50E-5 14 2.75E-5
10 SGTC_1840 st055363 3.92 71.0 µM 7.22E-5 12 4.50E-5
11 SGTC_1245 0418-0076 3.83 17.2 µM 1.01E-4 ERG2 33 6.36E-5
12 SGTC_2472 5377652 3.78 49.4 µM 1.21E-4 TRP & mitochondrial translation 63 7.74E-5
13 SGTC_1248 0469-0687 3.73 58.6 µM 1.50E-4 36 9.65E-5
14 SGTC_1069 diphenylcyclopropenone 3.73 8.5 µM 1.50E-4 38 9.69E-5
15 SGTC_2027 5150920 3.71 200.0 µM 1.61E-4 16 1.04E-4
16 SGTC_2648 atorvastatin 3.65 78.7 µM 2.02E-4 azole & statin 25 1.32E-4
17 SGTC_1163 k060-0048 3.64 49.9 µM 2.11E-4 33 1.38E-4
18 SGTC_976 1348-1067 3.58 47.6 µM 2.57E-4 60S ribosome export 43 1.70E-4
19 SGTC_2104 5389443 3.51 200.0 µM 3.31E-4 29 2.21E-4
20 SGTC_941 3237-0776 3.45 460.0 µM 4.09E-4 34 2.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.04E-10 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.103 2.56E-9 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.100 7.14E-9 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.098 1.18E-8 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 4.19E-8 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.094 4.25E-8 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.090 2.10E-7 YKL029C MAE1 hom Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
0.089 2.58E-7 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.087 4.64E-7 YLR109W AHP1 hom Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
0.085 7.92E-7 YKR100C SKG1 hom Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
0.083 1.40E-6 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.082 1.78E-6 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.082 2.18E-6 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.082 2.29E-6 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.080 3.38E-6 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide