HIPHOP chemogenomics database
YIL113W / SDP1 
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YIL113W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.108 | 3.04E-10 | YPL245W_p | YPL245W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm |
| 0.103 | 2.56E-9 | YIR042C_p | YIR042C_p | hom | Putative protein of unknown function; YIR042C is a non-essential gene |
| 0.100 | 7.14E-9 | YOR033C | EXO1 | hom | 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress |
| 0.098 | 1.18E-8 | YEL067C_p | YEL067C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.094 | 4.19E-8 | YDL164C | CDC9 | het | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
| 0.094 | 4.25E-8 | YMR003W | AIM34 | hom | Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss |
| 0.090 | 2.10E-7 | YKL029C | MAE1 | hom | Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids |
| 0.089 | 2.58E-7 | YMR241W | YHM2 | hom | Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome |
| 0.087 | 4.64E-7 | YLR109W | AHP1 | hom | Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p |
| 0.085 | 7.92E-7 | YKR100C | SKG1 | hom | Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell |
| 0.083 | 1.40E-6 | YER067C-A_d | YER067C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W |
| 0.082 | 1.78E-6 | YNL082W | PMS1 | hom | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |
| 0.082 | 2.18E-6 | YEL008W_d | YEL008W_d | hom | Hypothetical protein predicted to be involved in metabolism |
| 0.082 | 2.29E-6 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
| 0.080 | 3.38E-6 | YGL130W | CEG1 | het | Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |