YIL115C / NUP159

FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL115C / NUP159

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:4.38|P-value:4.50E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:5.67|P-value:4.99E-9 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.43|P-value:3.17E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.65|P-value:8.18E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.97|P-value:3.75E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.56|P-value:1.55E-4 ID:SGTC_229|Compound:benomyl|FD-Score:-3.53|P-value:2.19E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.20|P-value:1.05E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.40|P-value:2.81E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.10|P-value:8.30E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.35|P-value:5.33E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:-9.70|P-value:1.23E-22 ID:SGTC_764|Compound:1951-2361|FD-Score:-6.84|P-value:3.95E-12 ID:SGTC_766|Compound:1391-0721|FD-Score:12.80|P-value:1.39E-38 ID:SGTC_768|Compound:0384-0033|FD-Score:6.68|P-value:7.52E-12 ID:SGTC_769|Compound:0302-0231|FD-Score:-8.50|P-value:8.64E-18 ID:SGTC_770|Compound:0389-1121|FD-Score:-4.91|P-value:4.70E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.71|P-value:1.11E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.16|P-value:6.75E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.61|P-value:1.54E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.75|P-value:7.80E-7 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.41|P-value:2.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.91|P-value:3.36E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.24|P-value:5.01E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.53|P-value:2.20E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.04|P-value:2.14E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.13|P-value:1.44E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.38|P-value:3.04E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.33|P-value:3.62E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.28|P-value:4.43E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.50|P-value:2.43E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.49|P-value:2.00E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.35|P-value:4.32E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.32|P-value:3.73E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.74|P-value:9.71E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.96|P-value:2.95E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.07|P-value:9.09E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.70|P-value:9.82E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-3.58|P-value:1.84E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.59|P-value:1.35E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.89|P-value:3.96E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:4.54|P-value:2.17E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-16.40|P-value:5.04E-61 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.73|P-value:7.82E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.81|P-value:5.71E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.41|P-value:3.97E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.42|P-value:3.34E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.54|P-value:2.10E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.34|P-value:4.39E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:1.76E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.29|P-value:4.45E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.67|P-value:1.16E-6 ID:SGTC_2973|Compound:9094665|FD-Score:9.25|P-value:5.25E-21 ID:SGTC_3101|Compound:9120531|FD-Score:5.53|P-value:1.16E-8 ID:SGTC_3124|Compound:9127567|FD-Score:-3.27|P-value:5.58E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.39|P-value:2.90E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.79|P-value:6.09E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.38|P-value:4.50E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:5.67|P-value:4.99E-9 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.43|P-value:3.17E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.65|P-value:8.18E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.97|P-value:3.75E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.56|P-value:1.55E-4 ID:SGTC_229|Compound:benomyl|FD-Score:-3.53|P-value:2.19E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.20|P-value:1.05E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.40|P-value:2.81E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.10|P-value:8.30E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.35|P-value:5.33E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:-9.70|P-value:1.23E-22 ID:SGTC_764|Compound:1951-2361|FD-Score:-6.84|P-value:3.95E-12 ID:SGTC_766|Compound:1391-0721|FD-Score:12.80|P-value:1.39E-38 ID:SGTC_768|Compound:0384-0033|FD-Score:6.68|P-value:7.52E-12 ID:SGTC_769|Compound:0302-0231|FD-Score:-8.50|P-value:8.64E-18 ID:SGTC_770|Compound:0389-1121|FD-Score:-4.91|P-value:4.70E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.71|P-value:1.11E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.16|P-value:6.75E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.61|P-value:1.54E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.75|P-value:7.80E-7 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.41|P-value:2.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.91|P-value:3.36E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.24|P-value:5.01E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.53|P-value:2.20E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.04|P-value:2.14E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.13|P-value:1.44E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.38|P-value:3.04E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.33|P-value:3.62E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.28|P-value:4.43E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.50|P-value:2.43E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.49|P-value:2.00E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.35|P-value:4.32E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.32|P-value:3.73E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.74|P-value:9.71E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.96|P-value:2.95E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.07|P-value:9.09E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.70|P-value:9.82E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-3.58|P-value:1.84E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.59|P-value:1.35E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.89|P-value:3.96E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:4.54|P-value:2.17E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-16.40|P-value:5.04E-61 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.73|P-value:7.82E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.81|P-value:5.71E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.41|P-value:3.97E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.42|P-value:3.34E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.54|P-value:2.10E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.34|P-value:4.39E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:1.76E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.29|P-value:4.45E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.67|P-value:1.16E-6 ID:SGTC_2973|Compound:9094665|FD-Score:9.25|P-value:5.25E-21 ID:SGTC_3101|Compound:9120531|FD-Score:5.53|P-value:1.16E-8 ID:SGTC_3124|Compound:9127567|FD-Score:-3.27|P-value:5.58E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.39|P-value:2.90E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.79|P-value:6.09E-5

Top fitness defect scores for YIL115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_766 1391-0721 12.80 126.0 µM 1.39E-38 1 4.97E-38 8.31
2 SGTC_2973 9094665 9.25 18.0 µM 5.25E-21 NEO1 3 1.11E-20 0.79
3 SGTC_768 0384-0033 6.68 77.3 µM 7.52E-12 fatty acid desaturase (OLE1) 7 1.19E-11 0.29
4 SGTC_62 0180-0423 5.67 3.2 µM 4.99E-9 60S ribosome export 4 7.15E-9 0.80
5 SGTC_3101 9120531 5.53 49.5 µM 1.16E-8 3 1.64E-8 0.61
6 SGTC_2968 9090663 5.29 33.4 µM 4.45E-8 6 6.17E-8 0.11
7 SGTC_1203 3992-3522 4.91 103.0 µM 3.36E-7 7 4.51E-7 0.29
8 SGTC_915 methyl methanesulfonate (MMS) 4.75 110.0 mM 7.80E-7 DNA damage response 6 1.03E-6 0.05
9 SGTC_2450 5739737 4.70 12.9 µM 9.82E-7 2 1.30E-6 0.50
10 SGTC_2971 9092186 4.67 9.9 µM 1.16E-6 ergosterol biosynthesis 7 1.53E-6 0.21
11 SGTC_883 0850-0245 4.61 24.6 µM 1.54E-6 cell wall 3 2.02E-6 0.22
12 SGTC_2607 solasodine 4.54 47.4 µM 2.17E-6 8 2.82E-6 0.07
13 SGTC_2726 cimetidine 4.41 79.3 µM 3.97E-6 2 5.12E-6 0.63
14 SGTC_55 0767-0285 4.38 6.6 µM 4.50E-6 5 5.80E-6 0.20
15 SGTC_635 k038-0028 4.35 24.7 µM 5.33E-6 ubiquinone biosynthesis & proteasome 12 6.84E-6 0.04
16 SGTC_518 1021-0119 4.20 62.6 µM 1.05E-5 ERG2 6 1.34E-5 0.10
17 SGTC_1529 apigenin 4.13 74.0 µM 1.44E-5 4 1.81E-5 0.19
18 SGTC_1510 1123-0200 4.04 71.5 µM 2.14E-5 15 2.69E-5 0.07
19 SGTC_2389 9091542 3.96 195.5 µM 2.95E-5 iron homeostasis 6 3.68E-5 0.20
20 SGTC_2586 curcumin 3.89 80.0 µM 3.96E-5 iron homeostasis 10 4.92E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.298 5.28E-70 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.274 5.06E-59 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.251 3.56E-49 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.220 4.47E-38 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.195 5.24E-30 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.190 1.71E-28 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.186 1.25E-27 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.176 1.15E-24 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.176 1.21E-24 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.169 5.16E-23 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.169 8.61E-23 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.168 1.48E-22 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.158 3.52E-20 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.149 3.93E-18 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.145 2.47E-17 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34