YIL120W / QDR1

Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL120W / QDR1

Click on Significant Values for Screen Details ID:SGTC_194|Compound:1486-1323|FD-Score:3.11|P-value:6.73E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.65|P-value:8.78E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:4.19|P-value:8.50E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.21|P-value:4.73E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.34|P-value:4.17E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.11|P-value:6.90E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.22|P-value:6.24E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.08|P-value:7.70E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.90|P-value:3.04E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.43|P-value:4.05E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:5.81|P-value:1.37E-9 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.23|P-value:4.36E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.64|P-value:1.00E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.33|P-value:3.08E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.78|P-value:7.09E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.01|P-value:9.77E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-5.00|P-value:2.33E-7 ID:SGTC_1833|Compound:st055984|FD-Score:-3.37|P-value:3.55E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-4.06|P-value:2.18E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.21|P-value:6.48E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.66|P-value:1.17E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.76|P-value:5.60E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.28|P-value:5.01E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.65|P-value:1.37E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:3.11|P-value:6.73E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.65|P-value:8.78E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:4.19|P-value:8.50E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.21|P-value:4.73E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.34|P-value:4.17E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.11|P-value:6.90E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.22|P-value:6.24E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.08|P-value:7.70E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.90|P-value:3.04E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.43|P-value:4.05E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:5.81|P-value:1.37E-9 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.23|P-value:4.36E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.64|P-value:1.00E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.33|P-value:3.08E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.78|P-value:7.09E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.01|P-value:9.77E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-5.00|P-value:2.33E-7 ID:SGTC_1833|Compound:st055984|FD-Score:-3.37|P-value:3.55E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-4.06|P-value:2.18E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.21|P-value:6.48E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.66|P-value:1.17E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.76|P-value:5.60E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.28|P-value:5.01E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.65|P-value:1.37E-6

Top fitness defect scores for YIL120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_968 1309-0633 5.81 340.0 µM 1.37E-9 3 3.13E-9
2 SGTC_1162 k048-0130 4.64 20.1 µM 1.00E-6 Golgi 12 1.78E-6
3 SGTC_611 3453-1652 4.34 23.7 µM 4.17E-6 12 7.00E-6
4 SGTC_199 4063-0024 4.19 41.6 µM 8.50E-6 4 1.39E-5
5 SGTC_959 1222-0044 3.90 107.0 µM 3.04E-5 19 4.73E-5
6 SGTC_2384 9036245 3.76 200.0 µM 5.60E-5 35 8.50E-5
7 SGTC_196 k015-0023 3.65 18.1 µM 8.78E-5 PDR1 31 1.31E-4
8 SGTC_956 1185-0240 3.54 191.0 µM 1.39E-4 36 2.04E-4
9 SGTC_2127 5253358 3.48 187.9 µM 1.73E-4 37 2.51E-4
10 SGTC_1196 1588-0294 3.33 184.0 µM 3.08E-4 29 4.37E-4
11 SGTC_1158 4092-0494 3.23 91.8 µM 4.36E-4 37 6.09E-4
12 SGTC_359 0081-0058 3.21 15.9 µM 4.73E-4 60S ribosome export 87 6.59E-4
13 SGTC_194 1486-1323 3.11 56.9 µM 6.73E-4 40 9.24E-4
14 SGTC_635 k038-0028 3.11 24.7 µM 6.90E-4 ubiquinone biosynthesis & proteasome 87 9.48E-4
15 SGTC_1678 st019265 3.10 80.2 µM 7.04E-4 60S ribosome export 56 9.66E-4
16 SGTC_824 1304-0008 3.08 100.0 µM 7.70E-4 DNA damage response 81 0.00105
17 SGTC_1284 0929-0043 3.01 16.0 µM 9.77E-4 69 0.00132
18 SGTC_1762 st045503 2.99 25.5 µM 0.00104 71 0.00141
19 SGTC_2751 anetholtrithion 2.93 17.2 µM 0.00125 77 0.00167
20 SGTC_1455 4262-0120 2.93 131.0 µM 0.00127 plasma membrane duress 80 0.00170

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.33E-16 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.130 4.52E-14 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.120 3.20E-12 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.105 1.13E-9 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.100 5.54E-9 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.099 1.04E-8 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.096 2.53E-8 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.096 2.78E-8 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.094 4.22E-8 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.094 5.33E-8 YER081W SER3 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
0.088 3.80E-7 YPL119C-A_p YPL119C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.084 9.70E-7 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.081 2.55E-6 YDR538W PAD1 hom Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
0.080 3.20E-6 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.080 3.78E-6 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function