YIL126W / STH1

ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL126W / STH1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.66|P-value:2.39E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:5.08|P-value:2.05E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:5.95|P-value:7.76E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:7.73|P-value:2.06E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.56|P-value:1.05E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.25|P-value:2.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.19|P-value:2.84E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:5.46|P-value:5.23E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.15|P-value:4.09E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.79|P-value:1.44E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.97|P-value:3.03E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.24|P-value:3.16E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.05|P-value:2.30E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.96|P-value:7.02E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.95|P-value:7.68E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.87|P-value:9.01E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.96|P-value:7.08E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.04|P-value:6.45E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:10.20|P-value:7.05E-17 ID:SGTC_322|Compound:k048-0136|FD-Score:4.51|P-value:1.36E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.67|P-value:8.09E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:4.49|P-value:1.44E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.67|P-value:8.27E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.89|P-value:8.63E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.79|P-value:5.57E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.37|P-value:7.31E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.53|P-value:1.30E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.27|P-value:2.57E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.91|P-value:8.10E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.04|P-value:4.09E-11 ID:SGTC_566|Compound:0958-0068|FD-Score:5.46|P-value:5.28E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:10.00|P-value:2.40E-16 ID:SGTC_643|Compound:k048-0106|FD-Score:6.97|P-value:9.04E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:8.69|P-value:1.06E-12 ID:SGTC_733|Compound:4069-0007|FD-Score:6.36|P-value:1.41E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:6.39|P-value:1.19E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:4.15|P-value:4.06E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:4.34|P-value:2.28E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.25|P-value:3.03E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.91|P-value:1.17E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:9.67|P-value:2.67E-15 ID:SGTC_951|Compound:1171-0579|FD-Score:4.01|P-value:6.13E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.26|P-value:1.10E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.31|P-value:9.19E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:10.70|P-value:2.10E-18 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.59|P-value:4.27E-10 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.94|P-value:7.43E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.91|P-value:9.01E-7 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.23|P-value:1.22E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.50|P-value:7.43E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.50|P-value:1.40E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.42|P-value:1.59E-4 ID:SGTC_1652|Compound:st011932|FD-Score:5.84|P-value:1.18E-6 ID:SGTC_1672|Compound:st016598|FD-Score:3.87|P-value:8.90E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.79|P-value:5.52E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.65|P-value:2.57E-6 ID:SGTC_1731|Compound:st035964|FD-Score:4.15|P-value:4.05E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.55|P-value:1.19E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.48|P-value:1.50E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.18|P-value:3.78E-4 ID:SGTC_1945|Compound:st075991|FD-Score:5.66|P-value:2.47E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.18|P-value:3.71E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.09|P-value:4.32E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.42|P-value:1.82E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.01|P-value:6.14E-4 ID:SGTC_2066|Compound:5222451|FD-Score:8.45|P-value:4.12E-12 ID:SGTC_2071|Compound:5230951|FD-Score:4.90|P-value:3.83E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.50|P-value:1.42E-4 ID:SGTC_2111|Compound:5486399|FD-Score:7.80|P-value:1.42E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.76|P-value:1.65E-6 ID:SGTC_2186|Compound:6124449|FD-Score:4.85|P-value:4.60E-5 ID:SGTC_2225|Compound:6654152|FD-Score:7.19|P-value:3.04E-9 ID:SGTC_2241|Compound:6772625|FD-Score:4.16|P-value:3.92E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.67|P-value:2.37E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.25|P-value:2.73E-4 ID:SGTC_2256|Compound:7954252|FD-Score:5.09|P-value:1.99E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.75|P-value:6.31E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.47|P-value:5.08E-6 ID:SGTC_2326|Compound:6164455|FD-Score:5.91|P-value:8.89E-7 ID:SGTC_2336|Compound:9001819|FD-Score:9.30|P-value:2.68E-14 ID:SGTC_2344|Compound:7990960|FD-Score:5.33|P-value:8.28E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.50|P-value:1.40E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.42|P-value:1.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.72|P-value:1.92E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.97|P-value:3.79E-16 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:9.23|P-value:4.32E-14 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.28|P-value:1.03E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.14|P-value:1.67E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.85|P-value:4.52E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.77|P-value:2.26E-8 ID:SGTC_2890|Compound:9046729|FD-Score:4.48|P-value:1.49E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.60|P-value:6.93E-18 ID:SGTC_2928|Compound:9011484|FD-Score:4.20|P-value:3.56E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.94|P-value:7.46E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.86|P-value:9.15E-4 ID:SGTC_3027|Compound:9089541|FD-Score:6.26|P-value:2.17E-7 ID:SGTC_3037|Compound:9091026|FD-Score:5.60|P-value:3.05E-6 ID:SGTC_3039|Compound:9090270|FD-Score:-4.21|P-value:3.10E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.05|P-value:4.90E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.30|P-value:8.33E-6 ID:SGTC_3110|Compound:9122132|FD-Score:3.90|P-value:8.23E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.72|P-value:2.82E-8 ID:SGTC_1|Compound:0258-0098|FD-Score:5.66|P-value:2.39E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:5.08|P-value:2.05E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:5.95|P-value:7.76E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:7.73|P-value:2.06E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.56|P-value:1.05E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.25|P-value:2.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.19|P-value:2.84E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:5.46|P-value:5.23E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.15|P-value:4.09E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.79|P-value:1.44E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.97|P-value:3.03E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.24|P-value:3.16E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.05|P-value:2.30E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.96|P-value:7.02E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.95|P-value:7.68E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.87|P-value:9.01E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.96|P-value:7.08E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.04|P-value:6.45E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:10.20|P-value:7.05E-17 ID:SGTC_322|Compound:k048-0136|FD-Score:4.51|P-value:1.36E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.67|P-value:8.09E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:4.49|P-value:1.44E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.67|P-value:8.27E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.89|P-value:8.63E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.79|P-value:5.57E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.37|P-value:7.31E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.53|P-value:1.30E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.27|P-value:2.57E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.91|P-value:8.10E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.04|P-value:4.09E-11 ID:SGTC_566|Compound:0958-0068|FD-Score:5.46|P-value:5.28E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:10.00|P-value:2.40E-16 ID:SGTC_643|Compound:k048-0106|FD-Score:6.97|P-value:9.04E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:8.69|P-value:1.06E-12 ID:SGTC_733|Compound:4069-0007|FD-Score:6.36|P-value:1.41E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:6.39|P-value:1.19E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:4.15|P-value:4.06E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:4.34|P-value:2.28E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.25|P-value:3.03E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.91|P-value:1.17E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:9.67|P-value:2.67E-15 ID:SGTC_951|Compound:1171-0579|FD-Score:4.01|P-value:6.13E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.26|P-value:1.10E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.31|P-value:9.19E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:10.70|P-value:2.10E-18 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.59|P-value:4.27E-10 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.94|P-value:7.43E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.91|P-value:9.01E-7 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.23|P-value:1.22E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.50|P-value:7.43E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.50|P-value:1.40E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.42|P-value:1.59E-4 ID:SGTC_1652|Compound:st011932|FD-Score:5.84|P-value:1.18E-6 ID:SGTC_1672|Compound:st016598|FD-Score:3.87|P-value:8.90E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.79|P-value:5.52E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.65|P-value:2.57E-6 ID:SGTC_1731|Compound:st035964|FD-Score:4.15|P-value:4.05E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.55|P-value:1.19E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.48|P-value:1.50E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.18|P-value:3.78E-4 ID:SGTC_1945|Compound:st075991|FD-Score:5.66|P-value:2.47E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.18|P-value:3.71E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.09|P-value:4.32E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.42|P-value:1.82E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.01|P-value:6.14E-4 ID:SGTC_2066|Compound:5222451|FD-Score:8.45|P-value:4.12E-12 ID:SGTC_2071|Compound:5230951|FD-Score:4.90|P-value:3.83E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.50|P-value:1.42E-4 ID:SGTC_2111|Compound:5486399|FD-Score:7.80|P-value:1.42E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.76|P-value:1.65E-6 ID:SGTC_2186|Compound:6124449|FD-Score:4.85|P-value:4.60E-5 ID:SGTC_2225|Compound:6654152|FD-Score:7.19|P-value:3.04E-9 ID:SGTC_2241|Compound:6772625|FD-Score:4.16|P-value:3.92E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.67|P-value:2.37E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.25|P-value:2.73E-4 ID:SGTC_2256|Compound:7954252|FD-Score:5.09|P-value:1.99E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.75|P-value:6.31E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.47|P-value:5.08E-6 ID:SGTC_2326|Compound:6164455|FD-Score:5.91|P-value:8.89E-7 ID:SGTC_2336|Compound:9001819|FD-Score:9.30|P-value:2.68E-14 ID:SGTC_2344|Compound:7990960|FD-Score:5.33|P-value:8.28E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.50|P-value:1.40E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.42|P-value:1.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.72|P-value:1.92E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.97|P-value:3.79E-16 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:9.23|P-value:4.32E-14 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.28|P-value:1.03E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.14|P-value:1.67E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.85|P-value:4.52E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.77|P-value:2.26E-8 ID:SGTC_2890|Compound:9046729|FD-Score:4.48|P-value:1.49E-4 ID:SGTC_2912|Compound:7964298|FD-Score:10.60|P-value:6.93E-18 ID:SGTC_2928|Compound:9011484|FD-Score:4.20|P-value:3.56E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.94|P-value:7.46E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.86|P-value:9.15E-4 ID:SGTC_3027|Compound:9089541|FD-Score:6.26|P-value:2.17E-7 ID:SGTC_3037|Compound:9091026|FD-Score:5.60|P-value:3.05E-6 ID:SGTC_3039|Compound:9090270|FD-Score:-4.21|P-value:3.10E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.05|P-value:4.90E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.30|P-value:8.33E-6 ID:SGTC_3110|Compound:9122132|FD-Score:3.90|P-value:8.23E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.72|P-value:2.82E-8

Top fitness defect scores for YIL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1133 3473-0247 10.70 50.0 µM 2.10E-18 RSC complex & mRNA processing 5 3.95E-27 0.20
2 SGTC_2912 7964298 10.60 10.9 µM 6.93E-18 cell wall 12 2.43E-26 0.20
3 SGTC_288 1315-0019 10.20 35.1 µM 7.05E-17 RSC & ERG11 2 8.24E-25 1.79
4 SGTC_586 0957-0265 10.00 8.2 µM 2.40E-16 cell wall 5 5.30E-24 0.25
5 SGTC_2408 sulbentine 9.97 18.4 µM 3.79E-16 6 1.06E-23 1.01
6 SGTC_871 0574-0004 9.67 149.0 µM 2.67E-15 5 2.05E-22 0.28
7 SGTC_2336 9001819 9.30 198.7 µM 2.68E-14 heme biosynthesis & mitochondrial translocase 11 6.80E-21 0.01
8 SGTC_2510 benzyl isothiocyanate 9.23 8.3 µM 4.32E-14 3 1.40E-20 1.19
9 SGTC_673 1082-0474 8.69 110.0 µM 1.06E-12 RSC complex & mRNA processing 17 1.81E-18 0.09
10 SGTC_2066 5222451 8.45 176.0 µM 4.12E-12 heme biosynthesis & mitochondrial translocase 6 1.42E-17 0.55
11 SGTC_525 k781-2675 8.04 26.7 µM 4.09E-11 redox potentiating 7 4.58E-16 0.20
12 SGTC_2111 5486399 7.80 200.0 µM 1.42E-10 8 3.03E-15 0.18
13 SGTC_22 0964-0034 7.73 14.5 µM 2.06E-10 unfolded protein response 6 5.32E-15 0.39
14 SGTC_1239 0337-0584 7.59 35.4 µM 4.27E-10 unfolded protein response 8 1.60E-14 0.32
15 SGTC_2225 6654152 7.19 15.4 µM 3.04E-9 14 3.13E-13 0.29
16 SGTC_268 camptothecin 7.04 39.6 µM 6.45E-9 DNA damage response 18 9.76E-13 0.09
17 SGTC_643 k048-0106 6.97 28.4 µM 9.04E-9 RSC & ERG11 7 1.63E-12 0.31
18 SGTC_829 1635-0120 6.91 117.0 µM 1.17E-8 DNA damage response 22 2.40E-12 0.07
19 SGTC_2766 oltipraz 6.77 83.9 µM 2.26E-8 heme requiring 9 6.49E-12 0.31
20 SGTC_3304 9125678 6.72 46.1 µM 2.82E-8 18 9.10E-12 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.564 3.66E-280 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.509 7.93E-221 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.493 6.03E-205 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.463 3.00E-178 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.428 3.09E-149 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.401 8.14E-130 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.396 8.95E-126 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.364 1.57E-105 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.358 9.07E-102 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.344 3.96E-94 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.337 1.43E-89 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.324 1.11E-82 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.319 2.67E-80 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.318 9.82E-80 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.302 1.19E-71 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p