YIL127C_p / RRT14

Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL127C / RRT14

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.73|P-value:7.33E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.06|P-value:9.39E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.15|P-value:5.84E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.26|P-value:4.48E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.14|P-value:1.24E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.46|P-value:2.13E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.64|P-value:8.81E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:6.20|P-value:9.59E-11 ID:SGTC_535|Compound:2293-4129|FD-Score:6.59|P-value:6.16E-12 ID:SGTC_538|Compound:2922-0838|FD-Score:3.89|P-value:3.12E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.31|P-value:3.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-3.33|P-value:3.52E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.04|P-value:9.83E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.16|P-value:6.47E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.49|P-value:1.63E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.64|P-value:8.96E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.65|P-value:8.54E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.06|P-value:7.94E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.11|P-value:6.81E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.92|P-value:3.29E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.45|P-value:1.88E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.83|P-value:3.34E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:4.20|P-value:7.55E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.45|P-value:2.26E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.41|P-value:3.46E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.82|P-value:4.93E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.20|P-value:9.54E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:5.58E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.11|P-value:7.74E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.73|P-value:7.33E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.06|P-value:9.39E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.15|P-value:5.84E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.26|P-value:4.48E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.14|P-value:1.24E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.46|P-value:2.13E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.64|P-value:8.81E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:6.20|P-value:9.59E-11 ID:SGTC_535|Compound:2293-4129|FD-Score:6.59|P-value:6.16E-12 ID:SGTC_538|Compound:2922-0838|FD-Score:3.89|P-value:3.12E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.31|P-value:3.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-3.33|P-value:3.52E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.10|P-value:7.04E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.04|P-value:9.83E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.16|P-value:6.47E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.49|P-value:1.63E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.64|P-value:8.96E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.65|P-value:8.54E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.06|P-value:7.94E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.11|P-value:6.81E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.92|P-value:3.29E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.45|P-value:1.88E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.83|P-value:3.34E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:4.20|P-value:7.55E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.45|P-value:2.26E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.41|P-value:3.46E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.82|P-value:4.93E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.20|P-value:9.54E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:5.58E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.11|P-value:7.74E-4

Top fitness defect scores for YIL127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_535 2293-4129 6.59 48.2 µM 6.16E-12 NEO1 23 2.13E-11
2 SGTC_534 k292-0788 6.20 63.4 µM 9.59E-11 mitochondrial processes 3 2.90E-10
3 SGTC_2340 7987427 4.83 183.4 µM 3.34E-7 15 6.77E-7
4 SGTC_533 1222-0222 4.64 6.7 µM 8.81E-7 PDR1 18 1.70E-6
5 SGTC_1282 0886-0010 4.26 32.4 µM 5.89E-6 endomembrane recycling 27 1.04E-5
6 SGTC_2516 gossypol 4.20 71.5 µM 7.55E-6 10 1.31E-5
7 SGTC_538 2922-0838 3.89 53.3 µM 3.12E-5 Golgi 31 5.07E-5
8 SGTC_2621 lithochol-11-enic acid 3.75 100.0 µM 5.58E-5 31 8.80E-5
9 SGTC_1286 0929-0070 3.65 131.0 µM 8.54E-5 22 1.32E-4
10 SGTC_1272 0839-0021 3.64 27.0 µM 8.96E-5 27 1.38E-4
11 SGTC_2922 7999257 3.51 32.5 µM 1.51E-4 20 2.27E-4
12 SGTC_1212 0520-0165 3.49 585.0 µM 1.63E-4 53 2.44E-4
13 SGTC_2321 7390090 3.45 138.8 µM 1.88E-4 46 2.79E-4
14 SGTC_707 0865-0008 3.31 204.0 µM 3.19E-4 DNA damage response 19 4.62E-4
15 SGTC_394 menadione 3.15 8.3 µM 5.84E-4 superoxide 61 8.20E-4
16 SGTC_2546 rhodinyl acetate 3.14 100.0 µM 6.08E-4 37 8.53E-4
17 SGTC_2005 4024620 3.11 188.0 µM 6.81E-4 61 9.50E-4
18 SGTC_781 4335-2806 3.10 94.4 µM 7.04E-4 48 9.80E-4
19 SGTC_2002 4023503 3.06 131.0 µM 7.94E-4 mitochondrial processes 83 0.00110
20 SGTC_2790 5423970 3.00 71.4 µM 9.70E-4 endomembrane recycling 120 0.00133

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.44E-12 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.102 3.97E-9 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.100 6.10E-9 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.100 6.92E-9 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.097 2.17E-8 YNL113W RPC19 het RNA polymerase subunit AC19, common to RNA polymerases I and III
0.095 3.23E-8 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.095 3.43E-8 YOR024W_d YOR024W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.94E-8 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.094 4.35E-8 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.094 4.70E-8 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.092 9.04E-8 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.092 1.04E-7 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.090 1.67E-7 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.087 4.34E-7 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.084 1.17E-6 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene