YIL133C / RPL16A

Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL133C / RPL16A

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.39|P-value:6.30E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.31|P-value:8.23E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.28|P-value:8.97E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.40|P-value:6.04E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.84|P-value:1.34E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-3.69|P-value:3.22E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.30|P-value:8.41E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:-4.01|P-value:1.05E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:4.11|P-value:4.89E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.35|P-value:7.21E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.57|P-value:1.14E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.70|P-value:2.20E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:7.05|P-value:1.42E-11 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.64|P-value:5.41E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.86|P-value:1.23E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.35|P-value:7.22E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.31|P-value:8.11E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.40|P-value:8.60E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.40|P-value:6.16E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.38|P-value:9.14E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.78|P-value:2.34E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.03|P-value:9.73E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.26|P-value:9.59E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.38|P-value:6.51E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.25|P-value:9.77E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.39|P-value:6.40E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.78|P-value:2.98E-6 ID:SGTC_2267|Compound:7931562|FD-Score:4.16|P-value:3.98E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.57|P-value:3.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.23|P-value:6.04E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:7.49E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.12|P-value:4.64E-5 ID:SGTC_2785|Compound:7756463|FD-Score:5.04|P-value:9.29E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-6.45|P-value:1.03E-9 ID:SGTC_3220|Compound:9131269|FD-Score:4.60|P-value:6.59E-6 ID:SGTC_3223|Compound:9129970|FD-Score:-5.22|P-value:6.45E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.69|P-value:3.24E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.39|P-value:6.30E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.31|P-value:8.23E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.28|P-value:8.97E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.40|P-value:6.04E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.84|P-value:1.34E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-3.69|P-value:3.22E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.30|P-value:8.41E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:-4.01|P-value:1.05E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:4.11|P-value:4.89E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.35|P-value:7.21E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.57|P-value:1.14E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.70|P-value:2.20E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:7.05|P-value:1.42E-11 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.64|P-value:5.41E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.86|P-value:1.23E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.35|P-value:7.22E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.31|P-value:8.11E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.40|P-value:8.60E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.40|P-value:6.16E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.38|P-value:9.14E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.78|P-value:2.34E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.03|P-value:9.73E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.26|P-value:9.59E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.38|P-value:6.51E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.25|P-value:9.77E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.39|P-value:6.40E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.78|P-value:2.98E-6 ID:SGTC_2267|Compound:7931562|FD-Score:4.16|P-value:3.98E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.57|P-value:3.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.23|P-value:6.04E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:7.49E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.12|P-value:4.64E-5 ID:SGTC_2785|Compound:7756463|FD-Score:5.04|P-value:9.29E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-6.45|P-value:1.03E-9 ID:SGTC_3220|Compound:9131269|FD-Score:4.60|P-value:6.59E-6 ID:SGTC_3223|Compound:9129970|FD-Score:-5.22|P-value:6.45E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.69|P-value:3.24E-4

Top fitness defect scores for YIL133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1126 isoteolin 7.05 1.0 µM 1.42E-11 2 8.93E-13
2 SGTC_2785 7756463 5.04 72.7 µM 9.29E-7 9 2.36E-7
3 SGTC_2264 7948757 4.78 110.8 µM 2.98E-6 6 8.76E-7
4 SGTC_1155 4088-0394 4.64 48.2 µM 5.41E-6 15 1.71E-6
5 SGTC_3220 9131269 4.60 49.5 µM 6.59E-6 6 2.13E-6
6 SGTC_589 1227-0070 4.16 34.1 µM 3.97E-5 25 1.59E-5
7 SGTC_2267 7931562 4.16 200.0 µM 3.98E-5 16 1.60E-5
8 SGTC_2779 methotrexate 4.12 400.0 µM 4.64E-5 25 1.89E-5
9 SGTC_850 0388-0143 4.11 75.9 µM 4.89E-5 10 2.01E-5
10 SGTC_1160 4092-0570 3.86 10.5 µM 1.23E-4 plasma membrane duress 42 5.63E-5
11 SGTC_475 α-linolenic acid 3.85 10.0 µM 1.30E-4 excess fatty acid 20 5.99E-5
12 SGTC_416 estradiol valerate 3.84 100.0 µM 1.34E-4 12 6.19E-5
13 SGTC_924 2046-0044 3.70 21.3 µM 2.20E-4 20 1.08E-4
14 SGTC_1992 st073643 3.68 23.3 µM 2.39E-4 mitochondrial processes 13 1.19E-4
15 SGTC_2274 7947094 3.57 46.1 µM 3.45E-4 49 1.78E-4
16 SGTC_168 3970-0862 3.40 530.5 µM 6.04E-4 165 3.33E-4
17 SGTC_1782 st039423 3.40 80.6 µM 6.16E-4 36 3.41E-4
18 SGTC_47 0149-0135 3.39 24.2 µM 6.30E-4 TSC3-RPN4 40 3.49E-4
19 SGTC_2089 5281248 3.39 129.7 µM 6.40E-4 superoxide 43 3.55E-4
20 SGTC_2064 5220758 3.38 200.0 µM 6.51E-4 63 3.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.05E-13 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.110 1.53E-10 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.108 3.11E-10 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.105 1.03E-9 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.103 2.52E-9 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.103 2.47E-9 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.102 2.71E-9 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.092 8.98E-8 YIL077C_p YIL077C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.090 1.99E-7 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance
0.089 2.44E-7 YDR017C KCS1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
0.087 3.85E-7 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.083 1.42E-6 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.083 1.52E-6 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.083 1.62E-6 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.083 1.68E-6 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication