YIL134C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL134C-A / YIL134C-A

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.19|P-value:4.41E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-2.97|P-value:9.37E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.20|P-value:4.14E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.06|P-value:7.15E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.72|P-value:5.22E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.02|P-value:7.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.75|P-value:4.69E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.91|P-value:2.16E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.07|P-value:6.97E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.26|P-value:3.34E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.06|P-value:7.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.05|P-value:7.29E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.18|P-value:4.60E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.13|P-value:5.46E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.07|P-value:6.95E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.99|P-value:9.14E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.17|P-value:4.67E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.21|P-value:4.09E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.28|P-value:3.13E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.59|P-value:9.18E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.61|P-value:7.40E-7 ID:SGTC_1638|Compound:st008370|FD-Score:-3.20|P-value:4.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.01|P-value:8.23E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.99|P-value:1.56E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.03|P-value:7.93E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.86|P-value:2.86E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.98|P-value:9.35E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.21|P-value:5.55E-6 ID:SGTC_2277|Compound:7947813|FD-Score:4.18|P-value:6.67E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.39|P-value:2.03E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.18|P-value:4.51E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_2461|Compound:5755302|FD-Score:2.97|P-value:9.65E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.18|P-value:6.30E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.72|P-value:5.05E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.28|P-value:3.03E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.11|P-value:5.94E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.14|P-value:8.05E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.11|P-value:5.70E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.55|P-value:1.03E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.04|P-value:7.32E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.56|P-value:9.86E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.09|P-value:6.42E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.19|P-value:4.41E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-2.97|P-value:9.37E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.20|P-value:4.14E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.06|P-value:7.15E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.72|P-value:5.22E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.02|P-value:7.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.75|P-value:4.69E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.91|P-value:2.16E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.07|P-value:6.97E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.26|P-value:3.34E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.06|P-value:7.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.05|P-value:7.29E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.18|P-value:4.60E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.13|P-value:5.46E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.07|P-value:6.95E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.99|P-value:9.14E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.17|P-value:4.67E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.21|P-value:4.09E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.28|P-value:3.13E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.59|P-value:9.18E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.61|P-value:7.40E-7 ID:SGTC_1638|Compound:st008370|FD-Score:-3.20|P-value:4.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.01|P-value:8.23E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.99|P-value:1.56E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.03|P-value:7.93E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.86|P-value:2.86E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.98|P-value:9.35E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.21|P-value:5.55E-6 ID:SGTC_2277|Compound:7947813|FD-Score:4.18|P-value:6.67E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.39|P-value:2.03E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.18|P-value:4.51E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_2461|Compound:5755302|FD-Score:2.97|P-value:9.65E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.18|P-value:6.30E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.72|P-value:5.05E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.28|P-value:3.03E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.11|P-value:5.94E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.14|P-value:8.05E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.11|P-value:5.70E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.55|P-value:1.03E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.04|P-value:7.32E-4 ID:SGTC_3246|Compound:9135460|FD-Score:-3.56|P-value:9.86E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.09|P-value:6.42E-4

Top fitness defect scores for YIL134C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2274 7947094 4.21 46.1 µM 5.55E-6 28 1.25E-5
2 SGTC_2277 7947813 4.18 106.9 µM 6.67E-6 RSC complex & mRNA processing 22 1.49E-5
3 SGTC_3052 9092717 4.14 49.5 µM 8.05E-6 21 1.77E-5
4 SGTC_1799 st045822 3.99 46.1 µM 1.56E-5 14 3.26E-5
5 SGTC_165 k038-0023 3.90 64.4 µM 2.40E-5 ubiquinone biosynthesis & proteasome 81 4.84E-5
6 SGTC_164 4100-3994 3.90 89.6 µM 2.40E-5 34 4.85E-5
7 SGTC_2073 5212005 3.86 126.0 µM 2.86E-5 8 5.70E-5
8 SGTC_444 curcumin 3.75 90.4 µM 4.69E-5 iron homeostasis 33 8.98E-5
9 SGTC_147 4466-0538 3.72 29.2 µM 5.22E-5 ergosterol biosynthesis 27 9.91E-5
10 SGTC_1584 6-fluoro-dl-tryptophan 3.59 90.0 µM 9.18E-5 mitochondrial processes 24 1.67E-4
11 SGTC_727 3032-0951 3.51 202.0 µM 1.24E-4 40 2.20E-4
12 SGTC_2614 arthonioic acid 3.46 13.4 µM 1.51E-4 32 2.65E-4
13 SGTC_936 3005-4620 3.40 401.0 µM 1.96E-4 47 3.37E-4
14 SGTC_2278 7948257 3.39 134.3 µM 2.03E-4 40 3.47E-4
15 SGTC_1508 1080-0625 3.28 72.9 µM 3.13E-4 38 5.18E-4
16 SGTC_2562 3',7'-dimethoxyflavone 3.28 64.9 µM 3.15E-4 62 5.22E-4
17 SGTC_687 k029-0044 3.26 34.9 µM 3.34E-4 PDR1 41 5.50E-4
18 SGTC_2361 9034121 3.25 116.0 µM 3.54E-4 RSC complex & mRNA processing 41 5.81E-4
19 SGTC_2116 5511452 3.24 16.9 µM 3.65E-4 39 5.97E-4
20 SGTC_2423 st077119 3.23 87.2 µM 3.84E-4 33 6.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.27E-10 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.095 3.82E-8 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.086 6.19E-7 YMR064W AEP1 hom Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
0.084 1.27E-6 YDR442W_d YDR442W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.48E-6 YER140W EMP65 hom ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.50E-6 YKL003C MRP17 hom Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
0.082 1.90E-6 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.077 8.69E-6 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.075 1.22E-5 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.075 1.53E-5 YPR047W MSF1 hom Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
0.074 1.84E-5 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.073 2.34E-5 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.073 2.61E-5 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.072 2.82E-5 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.071 3.87E-5 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication