YIL136W / OM45

Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL136W / OM45

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.11|P-value:1.99E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.23|P-value:6.41E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.76|P-value:8.70E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.80|P-value:7.25E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.18|P-value:6.82E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.76|P-value:9.72E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.46|P-value:2.73E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.21|P-value:6.78E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.26|P-value:5.79E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.11|P-value:2.02E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.21|P-value:6.73E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.34|P-value:4.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.93|P-value:4.30E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.13|P-value:1.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.29|P-value:5.15E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.33|P-value:3.91E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.34|P-value:7.34E-6 ID:SGTC_1915|Compound:st067105|FD-Score:4.60|P-value:2.17E-6 ID:SGTC_1959|Compound:st077091|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.18|P-value:7.47E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-5.06|P-value:1.74E-7 ID:SGTC_2345|Compound:9052315|FD-Score:3.36|P-value:3.97E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.42|P-value:3.16E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.61|P-value:1.57E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.20|P-value:6.15E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.83|P-value:5.79E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.98|P-value:3.24E-7 ID:SGTC_2842|Compound:9000675|FD-Score:5.11|P-value:1.58E-7 ID:SGTC_2846|Compound:9008642|FD-Score:7.53|P-value:2.46E-14 ID:SGTC_2878|Compound:9043973|FD-Score:3.64|P-value:1.41E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.11|P-value:8.43E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.42|P-value:3.16E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:3.29E-5 ID:SGTC_3320|Compound:9137005|FD-Score:4.44|P-value:4.46E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.11|P-value:1.99E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.23|P-value:6.41E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.76|P-value:8.70E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.80|P-value:7.25E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.18|P-value:6.82E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.76|P-value:9.72E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.46|P-value:2.73E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.21|P-value:6.78E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.26|P-value:5.79E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.11|P-value:2.02E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.21|P-value:6.73E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.34|P-value:4.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.93|P-value:4.30E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.13|P-value:1.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.29|P-value:5.15E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.33|P-value:3.91E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.34|P-value:7.34E-6 ID:SGTC_1915|Compound:st067105|FD-Score:4.60|P-value:2.17E-6 ID:SGTC_1959|Compound:st077091|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.18|P-value:7.47E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-5.06|P-value:1.74E-7 ID:SGTC_2345|Compound:9052315|FD-Score:3.36|P-value:3.97E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.42|P-value:3.16E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.61|P-value:1.57E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.20|P-value:6.15E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.83|P-value:5.79E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.98|P-value:3.24E-7 ID:SGTC_2842|Compound:9000675|FD-Score:5.11|P-value:1.58E-7 ID:SGTC_2846|Compound:9008642|FD-Score:7.53|P-value:2.46E-14 ID:SGTC_2878|Compound:9043973|FD-Score:3.64|P-value:1.41E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.11|P-value:8.43E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.42|P-value:3.16E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:3.29E-5 ID:SGTC_3320|Compound:9137005|FD-Score:4.44|P-value:4.46E-6

Top fitness defect scores for YIL136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2846 9008642 7.53 19.5 µM 2.46E-14 2 2.61E-14
2 SGTC_2842 9000675 5.11 19.5 µM 1.58E-7 6 1.58E-7
3 SGTC_2837 9008476 4.98 45.5 µM 3.24E-7 15 3.23E-7
4 SGTC_574 1315-0397 4.76 40.0 µM 9.72E-7 15 9.65E-7
5 SGTC_1915 st067105 4.60 30.6 µM 2.17E-6 RNA pol III & RNase P/MRP 24 2.15E-6
6 SGTC_3320 9137005 4.44 35.1 µM 4.46E-6 endomembrane recycling 8 4.40E-6
7 SGTC_1910 st062352 4.34 60.4 µM 7.34E-6 22 7.25E-6
8 SGTC_2079 5212404 4.25 121.0 µM 1.09E-5 9 1.08E-5
9 SGTC_1305 1181-0477 4.23 144.0 µM 1.20E-5 10 1.19E-5
10 SGTC_1521 st012942 4.13 49.4 µM 1.84E-5 28 1.82E-5
11 SGTC_100 0086-0128 4.11 49.6 µM 1.99E-5 copper-dependent oxidative stress 46 1.96E-5
12 SGTC_1149 3909-7961 4.11 23.3 µM 2.02E-5 16 1.98E-5
13 SGTC_3307 9126885 3.99 69.3 µM 3.29E-5 31 3.24E-5
14 SGTC_1378 2093-0007 3.93 380.0 nM 4.30E-5 23 4.23E-5
15 SGTC_274 sirtinol 3.80 40.1 µM 7.25E-5 24 7.12E-5
16 SGTC_120 rhodamine 6G 3.76 52.3 µM 8.70E-5 mitochondrial processes 40 8.53E-5
17 SGTC_738 1315-0003 3.70 72.4 µM 1.10E-4 32 1.07E-4
18 SGTC_93 0109-0045 3.67 59.2 µM 1.24E-4 DNA damage response 61 1.22E-4
19 SGTC_1206 3978-0017 3.66 132.0 µM 1.26E-4 ERG2 47 1.24E-4
20 SGTC_1262 0737-0114 3.64 49.6 µM 1.38E-4 29 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.17E-13 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.111 1.02E-10 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.111 1.11E-10 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.101 4.48E-9 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.094 4.91E-8 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.088 3.00E-7 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.088 3.14E-7 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.087 4.90E-7 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.086 5.88E-7 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.085 8.14E-7 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.083 1.35E-6 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.080 3.27E-6 YDR177W UBC1 het Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
0.080 3.52E-6 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.078 7.00E-6 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.074 1.80E-5 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication