YIL137C / TMA108

Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL137C / TMA108

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.25|P-value:4.53E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.14|P-value:6.71E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.79|P-value:4.98E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.66|P-value:9.27E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.89|P-value:9.10E-10 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.33|P-value:4.86E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.76|P-value:6.65E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.81|P-value:4.97E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.21|P-value:5.11E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.74|P-value:6.64E-5 ID:SGTC_1649|Compound:st011737|FD-Score:4.61|P-value:1.24E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.13|P-value:6.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.13|P-value:6.81E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.17|P-value:6.07E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.44|P-value:2.22E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.94|P-value:2.83E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.05|P-value:1.24E-7 ID:SGTC_2056|Compound:5235370|FD-Score:3.84|P-value:4.27E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.19|P-value:5.91E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.41|P-value:2.47E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.20|P-value:5.72E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.19|P-value:5.55E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.06|P-value:9.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.39|P-value:1.82E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.58|P-value:1.34E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:7.33E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.29|P-value:4.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:2.12E-5 ID:SGTC_2910|Compound:7948405|FD-Score:4.57|P-value:1.51E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.25|P-value:7.02E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.71|P-value:7.65E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-4.33|P-value:5.28E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.22|P-value:1.05E-10 ID:SGTC_3222|Compound:9128301|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.35|P-value:4.33E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:3.25|P-value:4.53E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.14|P-value:6.71E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.79|P-value:4.98E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.66|P-value:9.27E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.89|P-value:9.10E-10 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.14|P-value:6.62E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.33|P-value:4.86E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.76|P-value:6.65E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.81|P-value:4.97E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.21|P-value:5.11E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.74|P-value:6.64E-5 ID:SGTC_1649|Compound:st011737|FD-Score:4.61|P-value:1.24E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.13|P-value:6.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.13|P-value:6.81E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.17|P-value:6.07E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.44|P-value:2.22E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.94|P-value:2.83E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.05|P-value:1.24E-7 ID:SGTC_2056|Compound:5235370|FD-Score:3.84|P-value:4.27E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.19|P-value:5.91E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.41|P-value:2.47E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.20|P-value:5.72E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.19|P-value:5.55E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.06|P-value:9.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.39|P-value:1.82E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.58|P-value:1.34E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:7.33E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.29|P-value:4.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:2.12E-5 ID:SGTC_2910|Compound:7948405|FD-Score:4.57|P-value:1.51E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.25|P-value:7.02E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.71|P-value:7.65E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-4.33|P-value:5.28E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.22|P-value:1.05E-10 ID:SGTC_3222|Compound:9128301|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.35|P-value:4.33E-6

Top fitness defect scores for YIL137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 6.22 49.5 µM 1.05E-10 12 2.45E-10
2 SGTC_690 glyoxal 5.89 20.3 µM 9.10E-10 45 1.94E-9
3 SGTC_2582 agaric acid 5.39 100.0 µM 1.82E-8 redox potentiating 199 3.46E-8
4 SGTC_2038 4100038 5.05 31.0 µM 1.24E-7 plasma membrane duress 26 2.19E-7
5 SGTC_535 2293-4129 4.79 48.2 µM 4.98E-7 NEO1 41 8.34E-7
6 SGTC_2651 1327-0036 4.71 5.0 µM 7.33E-7 124 1.21E-6
7 SGTC_1649 st011737 4.61 51.3 µM 1.24E-6 21 2.01E-6
8 SGTC_2910 7948405 4.57 26.0 µM 1.51E-6 plasma membrane duress 17 2.42E-6
9 SGTC_3259 9138485 4.35 49.5 µM 4.33E-6 8 6.68E-6
10 SGTC_1235 benzylparaben 4.33 21.5 µM 4.86E-6 7 7.46E-6
11 SGTC_3026 9090633 4.25 49.5 µM 7.02E-6 14 1.06E-5
12 SGTC_2816 7982706 4.01 58.4 µM 2.12E-5 azole & statin 50 3.08E-5
13 SGTC_1998 st075797 3.94 76.8 µM 2.83E-5 mitochondrial response to ROS 17 4.06E-5
14 SGTC_2056 5235370 3.84 200.0 µM 4.27E-5 43 6.03E-5
15 SGTC_1499 4480-0877 3.81 67.3 µM 4.97E-5 8 6.98E-5
16 SGTC_1637 st007924 3.74 17.4 µM 6.64E-5 27 9.23E-5
17 SGTC_3127 9126946 3.71 49.5 µM 7.65E-5 ERG2 24 1.06E-4
18 SGTC_541 4513-1321 3.66 94.0 µM 9.27E-5 29 1.27E-4
19 SGTC_1635 st007035 3.60 42.4 µM 1.16E-4 239 1.57E-4
20 SGTC_1770 st043884 3.60 66.3 µM 1.19E-4 21 1.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.74E-24 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.173 6.72E-24 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.168 1.40E-22 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.165 5.95E-22 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.165 7.20E-22 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.158 3.59E-20 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.157 7.05E-20 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.138 8.27E-16 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.137 1.51E-15 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.135 3.71E-15 YIL101C XBP1 hom Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.131 2.36E-14 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.131 3.35E-14 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.130 3.66E-14 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.130 3.83E-14 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.130 3.79E-14 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W