YIL138C / TPM2

Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL138C / TPM2

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.37|P-value:6.20E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.99|P-value:8.32E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.76|P-value:1.93E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.86|P-value:1.34E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.27|P-value:8.56E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.23|P-value:9.79E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.47|P-value:1.18E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.24|P-value:9.35E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.04|P-value:6.81E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-7.40|P-value:8.08E-13 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.64|P-value:2.98E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-4.17|P-value:3.23E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:5.89|P-value:1.22E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.38|P-value:5.82E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:-3.75|P-value:1.60E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.64|P-value:2.39E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.98|P-value:1.24E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.19|P-value:4.57E-7 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.50|P-value:4.85E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.68|P-value:2.60E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.11|P-value:5.11E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.32|P-value:8.60E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.66|P-value:2.78E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.75|P-value:1.61E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.26|P-value:8.92E-4 ID:SGTC_2253|Compound:7938677|FD-Score:5.31|P-value:2.48E-7 ID:SGTC_2259|Compound:7964009|FD-Score:-3.68|P-value:2.08E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.62|P-value:3.11E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_2457|Compound:5731572|FD-Score:5.15|P-value:5.47E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.32|P-value:8.63E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.48|P-value:5.04E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.68|P-value:3.72E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.54|P-value:3.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.46|P-value:5.46E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.90|P-value:1.15E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.48|P-value:1.05E-7 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.40|P-value:6.74E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.52|P-value:9.49E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.36|P-value:7.65E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.44|P-value:1.05E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.24|P-value:9.29E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.13|P-value:3.87E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.85|P-value:1.37E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.28|P-value:2.62E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.50|P-value:3.87E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.86|P-value:1.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.32|P-value:7.30E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.57|P-value:3.80E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.89|P-value:9.49E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.37|P-value:6.20E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.99|P-value:8.32E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.76|P-value:1.93E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.86|P-value:1.34E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.27|P-value:8.56E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.23|P-value:9.79E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.47|P-value:1.18E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.24|P-value:9.35E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.04|P-value:6.81E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-7.40|P-value:8.08E-13 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.64|P-value:2.98E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-4.17|P-value:3.23E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.37|P-value:7.46E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:5.89|P-value:1.22E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.38|P-value:5.82E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:-3.75|P-value:1.60E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.64|P-value:2.39E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.98|P-value:1.24E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.19|P-value:4.57E-7 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.50|P-value:4.85E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.68|P-value:2.60E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.11|P-value:5.11E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.32|P-value:8.60E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.66|P-value:2.78E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.75|P-value:1.61E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.26|P-value:8.92E-4 ID:SGTC_2253|Compound:7938677|FD-Score:5.31|P-value:2.48E-7 ID:SGTC_2259|Compound:7964009|FD-Score:-3.68|P-value:2.08E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.62|P-value:3.11E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_2457|Compound:5731572|FD-Score:5.15|P-value:5.47E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.32|P-value:8.63E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.48|P-value:5.04E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.68|P-value:3.72E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.54|P-value:3.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.46|P-value:5.46E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.90|P-value:1.15E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.48|P-value:1.05E-7 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.40|P-value:6.74E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.52|P-value:9.49E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.36|P-value:7.65E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.44|P-value:1.05E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.24|P-value:9.29E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.13|P-value:3.87E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.85|P-value:1.37E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.28|P-value:2.62E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.50|P-value:3.87E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.86|P-value:1.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.32|P-value:7.30E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.57|P-value:3.80E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.89|P-value:9.49E-5

Top fitness defect scores for YIL138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1315 1237-0019 5.89 3.7 µM 1.22E-8 2 1.92E-9
2 SGTC_2601 securinine 5.48 100.0 µM 1.05E-7 7 2.08E-8
3 SGTC_2253 7938677 5.31 135.8 µM 2.48E-7 4 5.39E-8
4 SGTC_1511 0906-3109 5.19 28.5 µM 4.57E-7 excess fatty acid 19 1.06E-7
5 SGTC_2457 5731572 5.15 11.7 µM 5.47E-7 5 1.29E-7
6 SGTC_1482 3346-2049 4.98 8.5 µM 1.24E-6 19 3.20E-7
7 SGTC_2747 doxorubicin 4.52 7.6 µM 9.49E-6 anthracycline transcription coupled DNA repair 3 3.04E-6
8 SGTC_589 1227-0070 4.47 34.1 µM 1.18E-5 20 3.86E-6
9 SGTC_2926 9010726 4.28 65.2 µM 2.62E-5 25 9.38E-6
10 SGTC_1633 st005664 4.11 67.9 µM 5.11E-5 24 1.96E-5
11 SGTC_609 0986-0026 4.04 86.3 µM 6.81E-5 calcium & mitochondrial duress 29 2.69E-5
12 SGTC_35 0133-0054 3.99 64.1 µM 8.32E-5 32 3.36E-5
13 SGTC_2600 tangeritin 3.90 88.0 µM 1.15E-4 32 4.80E-5
14 SGTC_274 sirtinol 3.86 40.1 µM 1.34E-4 21 5.68E-5
15 SGTC_2907 7721985 3.85 69.9 µM 1.37E-4 24 5.82E-5
16 SGTC_2401 5128683 3.83 200.0 µM 1.48E-4 46 6.33E-5
17 SGTC_271 rotenone 3.76 740.0 µM 1.93E-4 31 8.52E-5
18 SGTC_1628 st004252 3.68 77.7 µM 2.60E-4 27 1.19E-4
19 SGTC_1845 st056753 3.66 3.0 µM 2.78E-4 TSC3-RPN4 45 1.27E-4
20 SGTC_2501 sodium tetradecyl sulfate 3.64 13.4 µM 2.97E-4 39 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 4.16E-8 YPL174C NIP100 hom Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
0.091 1.19E-7 YJR031C GEA1 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.089 2.63E-7 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.086 5.53E-7 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.081 2.29E-6 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.077 8.22E-6 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.076 1.10E-5 YLR342W-A_p YLR342W-A_p hom Putative protein of unknown function
0.074 1.60E-5 YLR249W YEF3 het Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
0.073 2.40E-5 YPR169W JIP5 het Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
0.073 2.57E-5 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.072 3.19E-5 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.072 3.31E-5 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.070 4.56E-5 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.066 1.42E-4 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.064 1.98E-4 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase