HIPHOP chemogenomics database
YIL141W_d 
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIL141W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.123 | 8.24E-13 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
| 0.093 | 7.08E-8 | YLR117C | CLF1 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
| 0.092 | 1.03E-7 | YMR225C | MRPL44 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
| 0.088 | 2.89E-7 | YLR168C | UPS2 | hom | Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI |
| 0.085 | 7.23E-7 | YFR006W_p | YFR006W_p | hom | Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene |
| 0.082 | 2.05E-6 | YNL122C_p | YNL122C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene |
| 0.081 | 2.38E-6 | YML068W | ITT1 | hom | Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins |
| 0.081 | 2.48E-6 | YBR280C | SAF1 | hom | F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 |
| 0.080 | 3.53E-6 | YMR132C_p | JLP2_p | hom | Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) |
| 0.080 | 3.61E-6 | YER183C | FAU1 | hom | 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis |
| 0.080 | 3.92E-6 | YLR410W | VIP1 | hom | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 |
| 0.077 | 7.13E-6 | YGL176C_p | YGL176C_p | hom | Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype |
| 0.077 | 8.21E-6 | YIL145C | PAN6 | hom | Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC |
| 0.076 | 9.50E-6 | YGR210C_p | YGR210C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| 0.076 | 1.00E-5 | YBR264C | YPT10 | hom | Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles |