YIL141W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL141W / YIL141W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.35|P-value:6.07E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:3.31|P-value:4.26E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.29|P-value:4.48E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.90|P-value:4.34E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.19|P-value:7.55E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.50|P-value:2.06E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.71|P-value:1.13E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.06|P-value:2.14E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.76|P-value:9.34E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.15|P-value:7.45E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:2.44E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.36|P-value:3.50E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.20|P-value:7.32E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.58|P-value:1.84E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.68|P-value:1.29E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.53|P-value:1.83E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.69|P-value:1.20E-6 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.31|P-value:5.11E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.27|P-value:4.93E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-5.39|P-value:3.97E-8 ID:SGTC_2412|Compound:st077135|FD-Score:-4.75|P-value:1.12E-6 ID:SGTC_2460|Compound:5552655|FD-Score:4.23|P-value:1.03E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.56|P-value:1.66E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.79|P-value:6.81E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.53|P-value:2.51E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.82|P-value:5.99E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-5.06|P-value:2.32E-7 ID:SGTC_2794|Compound:7785382|FD-Score:6.85|P-value:2.87E-12 ID:SGTC_2838|Compound:9002687|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.76|P-value:9.32E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.98|P-value:9.21E-10 ID:SGTC_3066|Compound:9117245|FD-Score:-5.00|P-value:3.23E-7 ID:SGTC_3076|Compound:9116187|FD-Score:9.09|P-value:3.48E-20 ID:SGTC_3094|Compound:9117742|FD-Score:5.86|P-value:1.93E-9 ID:SGTC_3203|Compound:9113543|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.25|P-value:9.17E-6 ID:SGTC_3346|Compound:9158254|FD-Score:5.04|P-value:1.98E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.35|P-value:6.07E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:3.31|P-value:4.26E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.29|P-value:4.48E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.90|P-value:4.34E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.19|P-value:7.55E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.50|P-value:2.06E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.71|P-value:1.13E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.06|P-value:2.14E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.76|P-value:9.34E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.15|P-value:7.45E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:2.44E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.36|P-value:3.50E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.20|P-value:7.32E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.58|P-value:1.84E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.68|P-value:1.29E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.53|P-value:1.83E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.69|P-value:1.20E-6 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.31|P-value:5.11E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.27|P-value:4.93E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-5.39|P-value:3.97E-8 ID:SGTC_2412|Compound:st077135|FD-Score:-4.75|P-value:1.12E-6 ID:SGTC_2460|Compound:5552655|FD-Score:4.23|P-value:1.03E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.56|P-value:1.66E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.79|P-value:6.81E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.53|P-value:2.51E-6 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.82|P-value:5.99E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-5.06|P-value:2.32E-7 ID:SGTC_2794|Compound:7785382|FD-Score:6.85|P-value:2.87E-12 ID:SGTC_2838|Compound:9002687|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.76|P-value:9.32E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.61|P-value:1.66E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.98|P-value:9.21E-10 ID:SGTC_3066|Compound:9117245|FD-Score:-5.00|P-value:3.23E-7 ID:SGTC_3076|Compound:9116187|FD-Score:9.09|P-value:3.48E-20 ID:SGTC_3094|Compound:9117742|FD-Score:5.86|P-value:1.93E-9 ID:SGTC_3203|Compound:9113543|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.25|P-value:9.17E-6 ID:SGTC_3346|Compound:9158254|FD-Score:5.04|P-value:1.98E-7

Top fitness defect scores for YIL141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3076 9116187 9.09 49.5 µM 3.48E-20 1 4.77E-20
2 SGTC_2794 7785382 6.85 27.3 µM 2.87E-12 2 3.60E-12
3 SGTC_3065 9113888 5.98 49.5 µM 9.21E-10 5 1.12E-9
4 SGTC_3094 9117742 5.86 49.5 µM 1.93E-9 6 2.33E-9
5 SGTC_3346 9158254 5.04 43.6 µM 1.98E-7 4 2.32E-7
6 SGTC_2235 salicylic acid 4.69 500.0 µM 1.20E-6 3 1.39E-6
7 SGTC_2729 fluphenazine 4.53 10.7 µM 2.51E-6 5 2.89E-6
8 SGTC_20 0481-0013 4.35 4.9 µM 6.07E-6 15 6.95E-6
9 SGTC_3205 9113483 4.25 49.5 µM 9.17E-6 19 1.05E-5
10 SGTC_2460 5552655 4.23 174.2 µM 1.03E-5 amide catabolism 26 1.18E-5
11 SGTC_3003 9075612 4.18 71.4 µM 1.25E-5 16 1.43E-5
12 SGTC_1189 1431-2119 4.06 7.3 µM 2.14E-5 21 2.42E-5
13 SGTC_237 nikkomycin 3.90 200.0 µM 4.34E-5 RSC complex & mRNA processing 14 4.90E-5
14 SGTC_2742 clothiapine 3.82 36.3 µM 5.99E-5 NEO1 13 6.74E-5
15 SGTC_2725 haloperidol 3.79 53.2 µM 6.81E-5 plasma membrane duress 41 7.66E-5
16 SGTC_2589 lobaric acid 3.56 100.0 µM 1.66E-4 33 1.85E-4
17 SGTC_2765 myclobutanil 3.55 7.7 µM 1.69E-4 azole & statin 67 1.89E-4
18 SGTC_3203 9113543 3.55 49.5 µM 1.72E-4 44 1.91E-4
19 SGTC_167 3672-0051 3.55 66.2 µM 1.72E-4 53 1.92E-4
20 SGTC_2129 girgensonine 3.53 121.0 µM 1.83E-4 heme biosynthesis & mitochondrial translocase 44 2.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.24E-13 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.093 7.08E-8 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.092 1.03E-7 YMR225C MRPL44 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.088 2.89E-7 YLR168C UPS2 hom Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI
0.085 7.23E-7 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.082 2.05E-6 YNL122C_p YNL122C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
0.081 2.38E-6 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.081 2.48E-6 YBR280C SAF1 hom F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
0.080 3.53E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.080 3.61E-6 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.080 3.92E-6 YLR410W VIP1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
0.077 7.13E-6 YGL176C_p YGL176C_p hom Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
0.077 8.21E-6 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.076 9.50E-6 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.076 1.00E-5 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles