YIL142W / CCT2

Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL142W / CCT2

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.76|P-value:2.67E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:5.06|P-value:1.59E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:3.90|P-value:1.68E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.94|P-value:2.67E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.70|P-value:7.42E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.64|P-value:4.07E-4 ID:SGTC_229|Compound:benomyl|FD-Score:10.10|P-value:7.26E-21 ID:SGTC_316|Compound:k060-0003|FD-Score:4.12|P-value:7.55E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.05|P-value:8.24E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:8.76E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.94|P-value:1.25E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.75|P-value:5.10E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:4.33|P-value:3.28E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.36|P-value:8.88E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:5.08|P-value:1.43E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.62|P-value:8.83E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.33|P-value:9.76E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.62|P-value:1.03E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.75|P-value:2.77E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.82|P-value:2.19E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.11|P-value:1.25E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.40|P-value:7.78E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.61|P-value:4.52E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:9.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.87|P-value:2.94E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.42|P-value:8.17E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.93|P-value:1.48E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.53|P-value:5.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.15|P-value:5.62E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.45|P-value:7.48E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.32|P-value:3.44E-5 ID:SGTC_1751|Compound:st044839|FD-Score:-3.35|P-value:9.12E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.09|P-value:7.07E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.50|P-value:6.47E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.48|P-value:6.87E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.30|P-value:3.87E-35 ID:SGTC_1880|Compound:MG-132|FD-Score:-6.31|P-value:2.29E-9 ID:SGTC_1931|Compound:st074438|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.10|P-value:1.31E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-6.29|P-value:2.58E-9 ID:SGTC_2050|Compound:5263056|FD-Score:4.08|P-value:8.47E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-4.23|P-value:4.26E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.59|P-value:4.82E-4 ID:SGTC_2151|Compound:5563267|FD-Score:8.90|P-value:1.07E-16 ID:SGTC_2174|Compound:5790901|FD-Score:8.13|P-value:3.09E-14 ID:SGTC_2319|Compound:6033012|FD-Score:3.91|P-value:1.57E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.30|P-value:3.21E-5 ID:SGTC_2352|Compound:9027995|FD-Score:5.14|P-value:1.07E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.46|P-value:7.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.29|P-value:3.34E-9 ID:SGTC_2400|Compound:5203494|FD-Score:4.05|P-value:9.76E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.46|P-value:2.02E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.77|P-value:2.63E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.83|P-value:2.10E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.41|P-value:8.60E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.27|P-value:3.57E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.41|P-value:7.53E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.68|P-value:3.08E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.79|P-value:2.09E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.41|P-value:2.44E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.39|P-value:9.23E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.44|P-value:6.75E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.89|P-value:1.50E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:5.77E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.57|P-value:1.13E-7 ID:SGTC_3209|Compound:9113616|FD-Score:-3.54|P-value:4.84E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.46|P-value:6.37E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.76|P-value:2.67E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:5.06|P-value:1.59E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:3.90|P-value:1.68E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.94|P-value:2.67E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.70|P-value:7.42E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.64|P-value:4.07E-4 ID:SGTC_229|Compound:benomyl|FD-Score:10.10|P-value:7.26E-21 ID:SGTC_316|Compound:k060-0003|FD-Score:4.12|P-value:7.55E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.05|P-value:8.24E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:8.76E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.94|P-value:1.25E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.75|P-value:5.10E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:4.33|P-value:3.28E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.36|P-value:8.88E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:5.08|P-value:1.43E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.62|P-value:8.83E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.33|P-value:9.76E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.62|P-value:1.03E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.75|P-value:2.77E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.82|P-value:2.19E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.11|P-value:1.25E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.40|P-value:7.78E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.61|P-value:4.52E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:9.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.87|P-value:2.94E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.42|P-value:8.17E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.93|P-value:1.48E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.53|P-value:5.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.15|P-value:5.62E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.45|P-value:7.48E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.32|P-value:3.44E-5 ID:SGTC_1751|Compound:st044839|FD-Score:-3.35|P-value:9.12E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.09|P-value:7.07E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.50|P-value:6.47E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.48|P-value:6.87E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.30|P-value:3.87E-35 ID:SGTC_1880|Compound:MG-132|FD-Score:-6.31|P-value:2.29E-9 ID:SGTC_1931|Compound:st074438|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.10|P-value:1.31E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-6.29|P-value:2.58E-9 ID:SGTC_2050|Compound:5263056|FD-Score:4.08|P-value:8.47E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-4.23|P-value:4.26E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.59|P-value:4.82E-4 ID:SGTC_2151|Compound:5563267|FD-Score:8.90|P-value:1.07E-16 ID:SGTC_2174|Compound:5790901|FD-Score:8.13|P-value:3.09E-14 ID:SGTC_2319|Compound:6033012|FD-Score:3.91|P-value:1.57E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.30|P-value:3.21E-5 ID:SGTC_2352|Compound:9027995|FD-Score:5.14|P-value:1.07E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.46|P-value:7.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.29|P-value:3.34E-9 ID:SGTC_2400|Compound:5203494|FD-Score:4.05|P-value:9.76E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.46|P-value:2.02E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.77|P-value:2.63E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.83|P-value:2.10E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.41|P-value:8.60E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.27|P-value:3.57E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.41|P-value:7.53E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.68|P-value:3.08E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.79|P-value:2.09E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.41|P-value:2.44E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.39|P-value:9.23E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.44|P-value:6.75E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.89|P-value:1.50E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:5.77E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.57|P-value:1.13E-7 ID:SGTC_3209|Compound:9113616|FD-Score:-3.54|P-value:4.84E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.46|P-value:6.37E-4

Top fitness defect scores for YIL142W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 13.30 6.0 µM 3.87E-35 tubulin folding & SWR complex 7 8.20E-41 2.73
2 SGTC_229 benomyl 10.10 22.9 µM 7.26E-21 tubulin folding & SWR complex 2 3.88E-24 1.64
3 SGTC_2151 5563267 8.90 85.4 µM 1.07E-16 7 2.86E-19 1.52
4 SGTC_2174 5790901 8.13 200.0 µM 3.09E-14 tubulin folding & SWR complex 3 2.15E-16 1.29
5 SGTC_2399 5884133 6.29 200.0 µM 3.34E-9 cell wall signaling 5 1.62E-10 0.02
6 SGTC_2352 9027995 5.14 87.8 µM 1.07E-6 tubulin folding & SWR complex 1 1.35E-7 0.89
7 SGTC_1103 duloxetine 5.11 36.1 µM 1.25E-6 2 1.62E-7 0.68
8 SGTC_1992 st073643 5.10 23.3 µM 1.31E-6 mitochondrial processes 2 1.71E-7 0.08
9 SGTC_754 3474-0146 5.08 171.0 µM 1.43E-6 copper-dependent oxidative stress 1 1.90E-7 0.85
10 SGTC_25 0118-0223 5.06 35.7 µM 1.59E-6 1 2.15E-7 0.82
11 SGTC_104 0074-0074 4.94 591.0 µM 2.67E-6 6 3.93E-7 0.16
12 SGTC_115 0527-0192 4.70 112.0 µM 7.42E-6 13 1.29E-6 0.13
13 SGTC_831 k061-1017 4.62 217.0 µM 1.03E-5 translation 5 1.91E-6 0.48
14 SGTC_2405 ticlatone 4.46 3.5 µM 2.02E-5 19 4.15E-6 0.09
15 SGTC_2841 9004761 4.41 39.0 µM 2.44E-5 amide catabolism 8 5.18E-6 0.66
16 SGTC_594 1487-1584 4.33 10.8 µM 3.28E-5 6 7.31E-6 0.10
17 SGTC_1643 st009866 4.32 20.2 µM 3.44E-5 20 7.73E-6 0.06
18 SGTC_316 k060-0003 4.12 58.6 µM 7.55E-5 4 1.93E-5 0.27
19 SGTC_2050 5263056 4.08 171.0 µM 8.47E-5 fatty acid desaturase (OLE1) 25 2.20E-5 0.08
20 SGTC_2400 5203494 4.05 178.7 µM 9.76E-5 RSC complex & mRNA processing 19 2.60E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 8.38E-122 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.375 8.17E-113 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.372 2.46E-110 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.339 5.29E-91 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.327 1.78E-84 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.297 2.26E-69 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.290 5.75E-66 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.287 9.17E-65 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.277 3.91E-60 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.252 7.33E-50 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.245 5.58E-47 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.239 8.14E-45 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.222 1.42E-38 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.217 6.78E-37 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.206 1.97E-33 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2