YIL144W / TID3

Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL144W / TID3

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:5.44|P-value:7.47E-8 ID:SGTC_3|Compound:0833-0587|FD-Score:4.80|P-value:1.78E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:7.07|P-value:3.93E-12 ID:SGTC_9|Compound:0092-0002|FD-Score:4.83|P-value:1.51E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.52|P-value:3.45E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.66|P-value:2.06E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.90|P-value:8.15E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.78|P-value:1.21E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.45|P-value:8.69E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.34|P-value:6.37E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.69|P-value:1.81E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.68|P-value:3.09E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.33|P-value:1.29E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:7.04|P-value:4.94E-12 ID:SGTC_202|Compound:3594-0513|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-6.59|P-value:7.90E-11 ID:SGTC_511|Compound:blebbistatin|FD-Score:-4.40|P-value:9.57E-6 ID:SGTC_512|Compound:prima-1|FD-Score:4.35|P-value:1.30E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.60|P-value:4.37E-6 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.47|P-value:3.76E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.90|P-value:8.23E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.38|P-value:5.55E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.62|P-value:2.37E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.29|P-value:1.68E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.44|P-value:4.07E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.73|P-value:2.45E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:4.11|P-value:3.68E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:-5.22|P-value:1.96E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.33|P-value:6.06E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.75|P-value:1.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.19|P-value:2.63E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.70|P-value:1.64E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-4.31|P-value:1.44E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.93|P-value:7.42E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.44|P-value:8.95E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.49|P-value:3.84E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.54|P-value:2.92E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.44|P-value:4.13E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.22|P-value:8.80E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:6.92E-5 ID:SGTC_1810|Compound:st050138|FD-Score:-3.77|P-value:1.22E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.65|P-value:3.53E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:10.80|P-value:6.29E-26 ID:SGTC_2012|Compound:4023501|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.77|P-value:2.04E-6 ID:SGTC_2086|Compound:5274770|FD-Score:4.62|P-value:4.10E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.22|P-value:2.32E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.34|P-value:5.88E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.34|P-value:6.25E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.75|P-value:1.16E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.53|P-value:3.22E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.61|P-value:2.49E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.89|P-value:1.03E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.52|P-value:3.15E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.52|P-value:6.28E-6 ID:SGTC_3238|Compound:9133470|FD-Score:-3.19|P-value:9.51E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.38|P-value:5.06E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.37|P-value:5.67E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:5.44|P-value:7.47E-8 ID:SGTC_3|Compound:0833-0587|FD-Score:4.80|P-value:1.78E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:7.07|P-value:3.93E-12 ID:SGTC_9|Compound:0092-0002|FD-Score:4.83|P-value:1.51E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.52|P-value:3.45E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.66|P-value:2.06E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.90|P-value:8.15E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.78|P-value:1.21E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.45|P-value:8.69E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.34|P-value:6.37E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.69|P-value:1.81E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.68|P-value:3.09E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.33|P-value:1.29E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:7.04|P-value:4.94E-12 ID:SGTC_202|Compound:3594-0513|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-6.59|P-value:7.90E-11 ID:SGTC_511|Compound:blebbistatin|FD-Score:-4.40|P-value:9.57E-6 ID:SGTC_512|Compound:prima-1|FD-Score:4.35|P-value:1.30E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.60|P-value:4.37E-6 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.47|P-value:3.76E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.90|P-value:8.23E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.38|P-value:5.55E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.62|P-value:2.37E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.29|P-value:1.68E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.44|P-value:4.07E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.73|P-value:2.45E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:4.11|P-value:3.68E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:-5.22|P-value:1.96E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.33|P-value:6.06E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.75|P-value:1.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.19|P-value:2.63E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.70|P-value:1.64E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-4.31|P-value:1.44E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.93|P-value:7.42E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.44|P-value:8.95E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.49|P-value:3.84E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.54|P-value:2.92E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.44|P-value:4.13E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.22|P-value:8.80E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:6.92E-5 ID:SGTC_1810|Compound:st050138|FD-Score:-3.77|P-value:1.22E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.65|P-value:3.53E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:10.80|P-value:6.29E-26 ID:SGTC_2012|Compound:4023501|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.77|P-value:2.04E-6 ID:SGTC_2086|Compound:5274770|FD-Score:4.62|P-value:4.10E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.22|P-value:2.32E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.34|P-value:5.88E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.34|P-value:6.25E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-5.75|P-value:1.16E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.53|P-value:3.22E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.61|P-value:2.49E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.89|P-value:1.03E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.52|P-value:3.15E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.52|P-value:6.28E-6 ID:SGTC_3238|Compound:9133470|FD-Score:-3.19|P-value:9.51E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.38|P-value:5.06E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.37|P-value:5.67E-4

Top fitness defect scores for YIL144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1926 methyl fluorone black 10.80 53.6 µM 6.29E-26 DNA intercalators 2 1.46E-27 1.91
2 SGTC_4 0960-0234 7.07 25.7 µM 3.93E-12 Golgi 2 7.49E-13 1.37
3 SGTC_166 k072-0058 7.04 166.4 µM 4.94E-12 DNA intercalators 2 9.56E-13 1.98
4 SGTC_2 0422-0095 5.44 29.0 µM 7.47E-8 redox potentiating 1 2.73E-8 1.25
5 SGTC_165 k038-0023 5.33 64.4 µM 1.29E-7 ubiquinone biosynthesis & proteasome 11 4.90E-8 0.12
6 SGTC_1107 amlodipine 5.19 47.0 µM 2.63E-7 2 1.05E-7 0.90
7 SGTC_9 0092-0002 4.83 10.4 µM 1.51E-6 4 6.72E-7 0.05
8 SGTC_3 0833-0587 4.80 95.6 µM 1.78E-6 redox potentiating 8 8.01E-7 0.03
9 SGTC_2028 5153890 4.77 36.4 µM 2.04E-6 cell wall signaling 6 9.28E-7 0.63
10 SGTC_794 k038-0031 4.73 316.0 µM 2.45E-6 ubiquinone biosynthesis & proteasome 13 1.13E-6 0.11
11 SGTC_145 3737-0113 4.68 38.4 µM 3.09E-6 DNA intercalators 35 1.45E-6 0.05
12 SGTC_1812 st052057 4.65 4.3 µM 3.53E-6 calcium & mitochondrial duress 5 1.66E-6 0.54
13 SGTC_2086 5274770 4.62 176.6 µM 4.10E-6 7 1.95E-6 0.09
14 SGTC_540 1187-0821 4.60 17.3 µM 4.37E-6 4 2.09E-6 0.01
15 SGTC_3142 9086498 4.52 49.5 µM 6.28E-6 iron homeostasis 36 3.08E-6 0.13
16 SGTC_86 0417-1630 4.45 471.9 µM 8.69E-6 ubiquinone biosynthesis & proteasome 22 4.34E-6 0.06
17 SGTC_1459 k035-0031 4.44 35.7 µM 8.95E-6 DNA intercalators 9 4.48E-6 0.09
18 SGTC_512 prima-1 4.35 270.0 µM 1.30E-5 DNA intercalators 10 6.66E-6 0.06
19 SGTC_738 1315-0003 4.29 72.4 µM 1.68E-5 5 8.74E-6 0.20
20 SGTC_2379 9035213 4.22 200.0 µM 2.32E-5 3 1.23E-5 0.43

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 1.99E-25 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.177 5.42E-25 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.174 3.93E-24 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.173 4.28E-24 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.168 9.81E-23 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.166 3.32E-22 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.164 1.29E-21 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.160 9.71E-21 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.160 1.25E-20 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.159 2.22E-20 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.158 3.96E-20 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.153 4.80E-19 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.152 7.85E-19 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.152 8.85E-19 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.145 2.38E-17 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p