YIL146C / ATG32

Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL146C / ATG32

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.03|P-value:6.29E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.04|P-value:8.55E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:3.07E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.39|P-value:1.60E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.14|P-value:5.94E-6 ID:SGTC_442|Compound:cape|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:4.20|P-value:4.26E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:-3.21|P-value:4.69E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.14|P-value:9.00E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.32|P-value:2.39E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.32|P-value:2.40E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.12|P-value:6.42E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.48|P-value:1.74E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.54|P-value:2.51E-9 ID:SGTC_1899|Compound:st063254|FD-Score:4.37|P-value:1.83E-6 ID:SGTC_1907|Compound:st060210|FD-Score:4.41|P-value:1.49E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.02|P-value:6.67E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.75|P-value:6.23E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.40|P-value:1.57E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.19|P-value:3.51E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.62|P-value:1.44E-9 ID:SGTC_2352|Compound:9027995|FD-Score:-3.61|P-value:9.66E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.97|P-value:1.28E-7 ID:SGTC_2678|Compound:equilin|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.86|P-value:1.42E-7 ID:SGTC_2800|Compound:7887935|FD-Score:-3.44|P-value:1.91E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.06|P-value:5.72E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.34|P-value:3.59E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.95E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.04|P-value:8.63E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.64|P-value:8.32E-5 ID:SGTC_3124|Compound:9127567|FD-Score:-3.74|P-value:5.52E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-4.93|P-value:1.63E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-4.62|P-value:8.69E-7 ID:SGTC_3218|Compound:9131285|FD-Score:-4.30|P-value:4.32E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-3.99|P-value:1.84E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.53|P-value:1.33E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.03|P-value:6.29E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.04|P-value:8.55E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:3.07E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.39|P-value:1.60E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.14|P-value:5.94E-6 ID:SGTC_442|Compound:cape|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:4.20|P-value:4.26E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:-3.21|P-value:4.69E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.14|P-value:9.00E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.32|P-value:2.39E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.32|P-value:2.40E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.12|P-value:6.42E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.48|P-value:1.74E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.54|P-value:2.51E-9 ID:SGTC_1899|Compound:st063254|FD-Score:4.37|P-value:1.83E-6 ID:SGTC_1907|Compound:st060210|FD-Score:4.41|P-value:1.49E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.02|P-value:6.67E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.75|P-value:6.23E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.40|P-value:1.57E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.19|P-value:3.51E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.62|P-value:1.44E-9 ID:SGTC_2352|Compound:9027995|FD-Score:-3.61|P-value:9.66E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-4.97|P-value:1.28E-7 ID:SGTC_2678|Compound:equilin|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.86|P-value:1.42E-7 ID:SGTC_2800|Compound:7887935|FD-Score:-3.44|P-value:1.91E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.06|P-value:5.72E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.34|P-value:3.59E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.95E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.04|P-value:8.63E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.64|P-value:8.32E-5 ID:SGTC_3124|Compound:9127567|FD-Score:-3.74|P-value:5.52E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-4.93|P-value:1.63E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-4.62|P-value:8.69E-7 ID:SGTC_3218|Compound:9131285|FD-Score:-4.30|P-value:4.32E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-3.99|P-value:1.84E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.53|P-value:1.33E-4

Top fitness defect scores for YIL146C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2126 5251174 5.75 33.9 µM 6.23E-10 3 4.35E-9
2 SGTC_2351 9026858 5.62 72.3 µM 1.44E-9 RNA processing & uracil transport 5 9.32E-9
3 SGTC_1844 rapamycin 5.54 4.0 nM 2.51E-9 100 1.54E-8
4 SGTC_2691 st077356 4.86 60.2 µM 1.42E-7 15 6.00E-7
5 SGTC_1907 st060210 4.41 83.7 µM 1.49E-6 11 5.06E-6
6 SGTC_2131 toluylene red 4.40 5.3 µM 1.57E-6 60S ribosome export 13 5.29E-6
7 SGTC_1899 st063254 4.37 59.6 µM 1.83E-6 8 6.08E-6
8 SGTC_1129 3453-1384 4.32 223.0 µM 2.39E-6 30 7.76E-6
9 SGTC_1133 3473-0247 4.32 50.0 µM 2.40E-6 RSC complex & mRNA processing 37 7.80E-6
10 SGTC_477 mead ethanolamide 4.20 10.0 µM 4.26E-6 4 1.31E-5
11 SGTC_432 NS 1619 4.14 61.3 µM 5.94E-6 23 1.77E-5
12 SGTC_1946 st076057 3.49 65.1 µM 1.07E-4 12 2.42E-4
13 SGTC_492 tmb-8 3.42 126.0 µM 1.39E-4 9 3.08E-4
14 SGTC_367 0335-0881 3.39 7.1 µM 1.60E-4 ubiquinone biosynthesis & proteasome 111 3.50E-4
15 SGTC_442 cape 3.31 100.0 µM 2.21E-4 28 4.70E-4
16 SGTC_1919 st067113 3.27 52.3 µM 2.55E-4 TSC3-RPN4 54 5.34E-4
17 SGTC_279 1273-0055 3.22 2.9 µM 3.07E-4 azole & statin 65 6.32E-4
18 SGTC_2961 9083290 3.20 32.5 µM 3.32E-4 40 6.78E-4
19 SGTC_2348 9022543 3.19 33.4 µM 3.51E-4 mitochondrial processes 54 7.14E-4
20 SGTC_2678 equilin 3.12 100.0 µM 4.60E-4 52 9.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 7.86E-27 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.161 8.04E-21 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.152 6.90E-19 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.139 6.04E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.139 7.09E-16 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.138 1.09E-15 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.133 9.55E-15 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.132 1.64E-14 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.129 6.44E-14 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.126 2.09E-13 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.125 3.78E-13 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.123 8.34E-13 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.117 8.78E-12 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.116 1.51E-11 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.115 2.04E-11 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress