YIL150C / MCM10

Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL150C / MCM10

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.42|P-value:6.55E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.90|P-value:1.26E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.76|P-value:2.08E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.61|P-value:9.69E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.79|P-value:1.89E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.92|P-value:1.18E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.57|P-value:4.80E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.87|P-value:1.93E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.10|P-value:6.04E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-6.08|P-value:6.16E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:3.46|P-value:6.95E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.66|P-value:3.53E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.61|P-value:4.16E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.07|P-value:1.31E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.43|P-value:7.64E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.96|P-value:2.11E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-5.99|P-value:1.02E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.43|P-value:7.69E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.00|P-value:8.63E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.50|P-value:6.00E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.69|P-value:3.21E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.75|P-value:2.56E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.52|P-value:5.70E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.03|P-value:9.62E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.03|P-value:9.64E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.96|P-value:1.02E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.01|P-value:1.25E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.48|P-value:6.44E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.51|P-value:5.87E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.50|P-value:5.00E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.39|P-value:8.68E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.45|P-value:1.90E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.58|P-value:4.71E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.45|P-value:5.88E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-5.51|P-value:1.24E-7 ID:SGTC_2334|Compound:9017922|FD-Score:-3.86|P-value:1.45E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.82|P-value:2.04E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.44|P-value:1.92E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.54|P-value:5.23E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.42|P-value:6.62E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.54|P-value:1.41E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.45|P-value:7.22E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.38|P-value:8.96E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.71|P-value:3.03E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.66|P-value:7.94E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.36|P-value:9.33E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.63|P-value:3.28E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.75|P-value:2.19E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-8.16|P-value:1.16E-14 ID:SGTC_2974|Compound:9094440|FD-Score:3.50|P-value:6.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.28|P-value:3.69E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.04|P-value:9.31E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.82|P-value:1.68E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.57|P-value:4.87E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.16|P-value:4.71E-5 ID:SGTC_3251|Compound:9135047|FD-Score:4.01|P-value:1.03E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.42|P-value:6.55E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.90|P-value:1.26E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.76|P-value:2.08E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.61|P-value:9.69E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.79|P-value:1.89E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.92|P-value:1.18E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.57|P-value:4.80E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.87|P-value:1.93E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.10|P-value:6.04E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-6.08|P-value:6.16E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:3.46|P-value:6.95E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.91|P-value:1.45E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.66|P-value:3.53E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.61|P-value:4.16E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.07|P-value:1.31E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.43|P-value:7.64E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.96|P-value:2.11E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-5.99|P-value:1.02E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.43|P-value:7.69E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.00|P-value:8.63E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.50|P-value:6.00E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.69|P-value:3.21E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.75|P-value:2.56E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.52|P-value:5.70E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.03|P-value:9.62E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.03|P-value:9.64E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.96|P-value:1.02E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.01|P-value:1.25E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.48|P-value:6.44E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.51|P-value:5.87E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.50|P-value:5.00E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.39|P-value:8.68E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.45|P-value:1.90E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.58|P-value:4.71E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.45|P-value:5.88E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-5.51|P-value:1.24E-7 ID:SGTC_2334|Compound:9017922|FD-Score:-3.86|P-value:1.45E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.82|P-value:2.04E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.44|P-value:1.92E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.54|P-value:5.23E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.42|P-value:6.62E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.54|P-value:1.41E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.45|P-value:7.22E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.38|P-value:8.96E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.71|P-value:3.03E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.66|P-value:7.94E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.36|P-value:9.33E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.63|P-value:3.28E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.75|P-value:2.19E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-8.16|P-value:1.16E-14 ID:SGTC_2974|Compound:9094440|FD-Score:3.50|P-value:6.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.28|P-value:3.69E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.04|P-value:9.31E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.82|P-value:1.68E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.57|P-value:4.87E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.16|P-value:4.71E-5 ID:SGTC_3251|Compound:9135047|FD-Score:4.01|P-value:1.03E-4

Top fitness defect scores for YIL150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2012 4023501 6.01 200.0 µM 1.25E-8 3 9.46E-10 0.84
2 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 5.54 92.6 µM 1.41E-7 3 1.54E-8 0.01
3 SGTC_910 3454-3003 5.07 490.0 µM 1.31E-6 3 2.00E-7 1.15
4 SGTC_1127 asiatic acid 4.96 681.4 nM 2.11E-6 4 3.47E-7 0.56
5 SGTC_2827 7993847 4.66 71.4 µM 7.94E-6 3 1.60E-6 0.11
6 SGTC_159 3970-0959 4.61 50.0 µM 9.69E-6 12 2.01E-6 0.09
7 SGTC_2119 5528445 4.45 120.6 µM 1.90E-5 1 4.35E-6 0.37
8 SGTC_2402 5553605 4.44 200.0 µM 1.92E-5 3 4.42E-6 0.18
9 SGTC_2975 9084847 4.28 53.7 µM 3.69E-5 7 9.35E-6 0.04
10 SGTC_3002 9075603 4.04 71.4 µM 9.31E-5 5 2.71E-5 0.23
11 SGTC_1767 st044992 4.03 70.3 µM 9.62E-5 2 2.82E-5 0.11
12 SGTC_1787 fluconazole 4.03 80.0 µM 9.64E-5 iron homeostasis 11 2.82E-5 0.25
13 SGTC_2674 ligustilide 4.02 100.0 µM 1.00E-4 5 2.95E-5 0.45
14 SGTC_3251 9135047 4.01 49.5 µM 1.03E-4 60S ribosome export 5 3.05E-5 0.37
15 SGTC_949 1165-0505 3.97 146.0 µM 1.19E-4 7 3.60E-5 0.15
16 SGTC_2937 9044753 3.97 11.3 µM 1.20E-4 60S ribosome export 9 3.62E-5 0.25
17 SGTC_1104 tacrolimus 3.97 29.8 µM 1.20E-4 8 3.63E-5 0.02
18 SGTC_520 3584-0023 3.91 682.0 µM 1.45E-4 13 4.53E-5 0.17
19 SGTC_1778 st046819 3.91 58.9 µM 1.49E-4 5 4.64E-5 0.13
20 SGTC_751 0833-0568 3.90 350.0 µM 1.56E-4 2 4.89E-5 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.72E-16 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.139 5.10E-16 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.135 4.45E-15 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.134 5.68E-15 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.133 1.12E-14 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.125 3.52E-13 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.109 2.77E-10 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.106 6.26E-10 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.105 1.02E-9 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.104 1.35E-9 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.104 1.43E-9 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.101 4.09E-9 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.099 8.56E-9 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.097 1.96E-8 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.096 2.42E-8 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W