YIL153W / RRD1

Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL153W / RRD1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.34|P-value:3.58E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.57|P-value:5.40E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.07|P-value:9.85E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.61|P-value:1.22E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:4.17|P-value:6.72E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.42|P-value:8.70E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.69|P-value:8.76E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:8.64|P-value:1.32E-15 ID:SGTC_138|Compound:0850-0259|FD-Score:4.18|P-value:6.61E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.19|P-value:6.24E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.65|P-value:4.24E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.49|P-value:2.52E-7 ID:SGTC_185|Compound:k048-0037|FD-Score:3.39|P-value:9.63E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.96|P-value:1.47E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.89|P-value:1.83E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.80|P-value:2.51E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.54|P-value:1.61E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.50|P-value:6.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.09|P-value:1.63E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:5.42|P-value:3.48E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.66|P-value:4.10E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.73|P-value:7.86E-8 ID:SGTC_665|Compound:3914-0008|FD-Score:5.16|P-value:1.18E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.49|P-value:2.54E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:5.45|P-value:3.13E-7 ID:SGTC_855|Compound:0428-0020|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.68|P-value:3.75E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.13|P-value:7.79E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.60|P-value:4.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.60|P-value:4.91E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.43|P-value:8.64E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.41|P-value:3.66E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.56|P-value:5.66E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.64|P-value:1.08E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.70|P-value:3.57E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.42|P-value:8.87E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.93|P-value:1.64E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.51|P-value:6.61E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.18|P-value:1.05E-6 ID:SGTC_1685|Compound:st024049|FD-Score:4.03|P-value:1.14E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.41|P-value:3.74E-7 ID:SGTC_1726|Compound:st035556|FD-Score:-9.01|P-value:8.10E-17 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.65|P-value:4.21E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.47|P-value:7.41E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.56|P-value:5.67E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.77|P-value:2.79E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.42|P-value:8.72E-4 ID:SGTC_1836|Compound:st055642|FD-Score:6.23|P-value:6.01E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:-9.45|P-value:2.67E-18 ID:SGTC_1991|Compound:st073000|FD-Score:3.47|P-value:7.47E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.99|P-value:1.28E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.82|P-value:2.33E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.68|P-value:3.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.57|P-value:1.43E-5 ID:SGTC_2352|Compound:9027995|FD-Score:5.63|P-value:1.26E-7 ID:SGTC_2433|Compound:5607874|FD-Score:4.07|P-value:9.70E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.46|P-value:2.21E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.45|P-value:2.33E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.92|P-value:1.67E-16 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.91|P-value:2.29E-13 ID:SGTC_2756|Compound:carbadox|FD-Score:5.78|P-value:6.27E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.98|P-value:1.34E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.09|P-value:9.12E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.54|P-value:1.65E-5 ID:SGTC_2845|Compound:9003024|FD-Score:6.77|P-value:2.87E-10 ID:SGTC_2846|Compound:9008642|FD-Score:-3.43|P-value:8.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.63|P-value:1.16E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.16|P-value:8.47E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.60|P-value:4.89E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.65|P-value:4.20E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.53|P-value:6.22E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.50|P-value:6.82E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.85|P-value:2.10E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.68|P-value:3.76E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-9.14|P-value:3.03E-17 ID:SGTC_3125|Compound:9127534|FD-Score:4.56|P-value:1.52E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-7.12|P-value:3.73E-11 ID:SGTC_3128|Compound:9127691|FD-Score:4.46|P-value:2.24E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.49|P-value:6.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:10.40|P-value:7.80E-22 ID:SGTC_3244|Compound:9134489|FD-Score:3.44|P-value:8.10E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.58|P-value:5.26E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.34|P-value:3.58E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.57|P-value:5.40E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.07|P-value:9.85E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.61|P-value:1.22E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:4.17|P-value:6.72E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.42|P-value:8.70E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.69|P-value:8.76E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:8.64|P-value:1.32E-15 ID:SGTC_138|Compound:0850-0259|FD-Score:4.18|P-value:6.61E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.19|P-value:6.24E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.65|P-value:4.24E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.49|P-value:2.52E-7 ID:SGTC_185|Compound:k048-0037|FD-Score:3.39|P-value:9.63E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.96|P-value:1.47E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.89|P-value:1.83E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.80|P-value:2.51E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.54|P-value:1.61E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.50|P-value:6.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.09|P-value:1.63E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:5.42|P-value:3.48E-7 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.66|P-value:4.10E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.73|P-value:7.86E-8 ID:SGTC_665|Compound:3914-0008|FD-Score:5.16|P-value:1.18E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.49|P-value:2.54E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:5.45|P-value:3.13E-7 ID:SGTC_855|Compound:0428-0020|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.68|P-value:3.75E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.13|P-value:7.79E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.60|P-value:4.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.60|P-value:4.91E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.43|P-value:8.64E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.41|P-value:3.66E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.56|P-value:5.66E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.64|P-value:1.08E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.70|P-value:3.57E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.42|P-value:8.87E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.93|P-value:1.64E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.51|P-value:6.61E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.18|P-value:1.05E-6 ID:SGTC_1685|Compound:st024049|FD-Score:4.03|P-value:1.14E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.41|P-value:3.74E-7 ID:SGTC_1726|Compound:st035556|FD-Score:-9.01|P-value:8.10E-17 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.65|P-value:4.21E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.47|P-value:7.41E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.56|P-value:5.67E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.77|P-value:2.79E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.42|P-value:8.72E-4 ID:SGTC_1836|Compound:st055642|FD-Score:6.23|P-value:6.01E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:-9.45|P-value:2.67E-18 ID:SGTC_1991|Compound:st073000|FD-Score:3.47|P-value:7.47E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.99|P-value:1.28E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.82|P-value:2.33E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.68|P-value:3.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.57|P-value:1.43E-5 ID:SGTC_2352|Compound:9027995|FD-Score:5.63|P-value:1.26E-7 ID:SGTC_2433|Compound:5607874|FD-Score:4.07|P-value:9.70E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.46|P-value:2.21E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.45|P-value:2.33E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.92|P-value:1.67E-16 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.91|P-value:2.29E-13 ID:SGTC_2756|Compound:carbadox|FD-Score:5.78|P-value:6.27E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.98|P-value:1.34E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.09|P-value:9.12E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.54|P-value:1.65E-5 ID:SGTC_2845|Compound:9003024|FD-Score:6.77|P-value:2.87E-10 ID:SGTC_2846|Compound:9008642|FD-Score:-3.43|P-value:8.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.63|P-value:1.16E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.16|P-value:8.47E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.60|P-value:4.89E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.65|P-value:4.20E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.53|P-value:6.22E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.50|P-value:6.82E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.85|P-value:2.10E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.68|P-value:3.76E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-9.14|P-value:3.03E-17 ID:SGTC_3125|Compound:9127534|FD-Score:4.56|P-value:1.52E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-7.12|P-value:3.73E-11 ID:SGTC_3128|Compound:9127691|FD-Score:4.46|P-value:2.24E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.49|P-value:6.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:10.40|P-value:7.80E-22 ID:SGTC_3244|Compound:9134489|FD-Score:3.44|P-value:8.10E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.58|P-value:5.26E-4

Top fitness defect scores for YIL153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 10.40 49.5 µM 7.80E-22 NEO1-PIK1 20 1.05E-25
2 SGTC_129 0088-0017 8.64 176.6 µM 1.32E-15 14 2.78E-18
3 SGTC_2741 miltefosine 7.91 3.0 µM 2.29E-13 9 1.29E-15
4 SGTC_2845 9003024 6.77 43.0 µM 2.87E-10 amide catabolism 13 6.32E-12
5 SGTC_1836 st055642 6.23 81.0 µM 6.01E-9 1 2.35E-10
6 SGTC_2912 7964298 6.16 10.9 µM 8.47E-9 cell wall 45 3.54E-10
7 SGTC_2756 carbadox 5.78 75.1 µM 6.27E-8 19 3.82E-9
8 SGTC_637 1181-0519 5.73 7.3 µM 7.86E-8 fatty acid desaturase (OLE1) 58 5.00E-9
9 SGTC_2352 9027995 5.63 87.8 µM 1.26E-7 tubulin folding & SWR complex 13 8.79E-9
10 SGTC_824 1304-0008 5.49 100.0 µM 2.54E-7 DNA damage response 10 2.02E-8
11 SGTC_829 1635-0120 5.45 117.0 µM 3.13E-7 DNA damage response 12 2.58E-8
12 SGTC_455 paf C-16 5.42 10.0 µM 3.48E-7 13 2.93E-8
13 SGTC_1113 artemisinin 5.41 1.2 µM 3.66E-7 heme biosynthesis & mitochondrial translocase 6 3.11E-8
14 SGTC_1707 st032323 5.41 6.3 µM 3.74E-7 DNA damage response 26 3.18E-8
15 SGTC_1672 st016598 5.18 6.5 µM 1.05E-6 endomembrane recycling 37 1.08E-7
16 SGTC_665 3914-0008 5.16 307.0 µM 1.18E-6 5 1.24E-7
17 SGTC_855 0428-0020 5.12 25.0 µM 1.40E-6 Golgi 9 1.53E-7
18 SGTC_453 enantio-paf c16 5.09 10.0 µM 1.63E-6 84 1.82E-7
19 SGTC_2896 9052656 4.63 71.4 µM 1.16E-5 endomembrane recycling 73 1.87E-6
20 SGTC_2339 9000433 4.57 200.0 µM 1.43E-5 17 2.41E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 1.30E-36 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.185 2.97E-27 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.160 1.49E-20 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.158 3.36E-20 YPR040W TIP41 hom Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
0.149 5.23E-18 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.146 1.94E-17 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.142 1.37E-16 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.129 5.69E-14 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.127 1.45E-13 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.127 1.93E-13 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.123 1.00E-12 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.123 1.07E-12 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.116 1.82E-11 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.114 3.06E-11 YCL010C SGF29 hom Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation
0.113 4.94E-11 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p