YIL155C / GUT2

Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL155C / GUT2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.08|P-value:6.90E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.21|P-value:4.12E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.44|P-value:1.74E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:5.17|P-value:2.19E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.95|P-value:2.52E-10 ID:SGTC_394|Compound:menadione|FD-Score:4.14|P-value:5.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.09|P-value:6.56E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.03|P-value:6.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.38|P-value:2.20E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-7.11|P-value:4.98E-14 ID:SGTC_697|Compound:0508-1955|FD-Score:3.17|P-value:3.68E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.26|P-value:3.45E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.72|P-value:5.34E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.06|P-value:5.64E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.80|P-value:1.80E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:1.80E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.18|P-value:4.65E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.47|P-value:6.30E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.43|P-value:8.81E-12 ID:SGTC_1618|Compound:st003135|FD-Score:4.20|P-value:4.22E-6 ID:SGTC_1674|Compound:st016616|FD-Score:3.55|P-value:8.00E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.66|P-value:6.79E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.58|P-value:7.17E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-5.80|P-value:6.83E-10 ID:SGTC_1748|Compound:st037455|FD-Score:3.30|P-value:2.30E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.03|P-value:8.23E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.07|P-value:5.42E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.73|P-value:2.72E-7 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.30|P-value:2.96E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.40|P-value:1.53E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.10|P-value:6.24E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.11|P-value:6.01E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.98|P-value:9.83E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.27|P-value:3.30E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.12|P-value:5.87E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-2.98|P-value:9.63E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-3.04|P-value:7.87E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.53|P-value:1.18E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.10|P-value:6.32E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.42|P-value:1.42E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.14|P-value:4.23E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.33|P-value:1.97E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.55|P-value:8.08E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.08|P-value:6.90E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.21|P-value:4.12E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.44|P-value:1.74E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:5.17|P-value:2.19E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.95|P-value:2.52E-10 ID:SGTC_394|Compound:menadione|FD-Score:4.14|P-value:5.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.09|P-value:6.56E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.03|P-value:6.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.38|P-value:2.20E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-7.11|P-value:4.98E-14 ID:SGTC_697|Compound:0508-1955|FD-Score:3.17|P-value:3.68E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.26|P-value:3.45E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.72|P-value:5.34E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.06|P-value:5.64E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.80|P-value:1.80E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:1.80E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.18|P-value:4.65E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.47|P-value:6.30E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.43|P-value:8.81E-12 ID:SGTC_1618|Compound:st003135|FD-Score:4.20|P-value:4.22E-6 ID:SGTC_1674|Compound:st016616|FD-Score:3.55|P-value:8.00E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.66|P-value:6.79E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.58|P-value:7.17E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-5.80|P-value:6.83E-10 ID:SGTC_1748|Compound:st037455|FD-Score:3.30|P-value:2.30E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.03|P-value:8.23E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.07|P-value:5.42E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.73|P-value:2.72E-7 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.30|P-value:2.96E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.40|P-value:1.53E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.10|P-value:6.24E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.11|P-value:6.01E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.98|P-value:9.83E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.27|P-value:3.30E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.12|P-value:5.87E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-2.98|P-value:9.63E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.34|P-value:1.91E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-3.04|P-value:7.87E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.53|P-value:1.18E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.10|P-value:6.32E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.42|P-value:1.42E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.14|P-value:4.23E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.33|P-value:1.97E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.55|P-value:8.08E-5

Top fitness defect scores for YIL155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_316 k060-0003 5.17 58.6 µM 2.19E-8 4 1.17E-7
2 SGTC_766 1391-0721 4.80 126.0 µM 1.80E-7 4 7.80E-7
3 SGTC_2338 7999974 4.73 200.0 µM 2.72E-7 8 1.13E-6
4 SGTC_2533 agelasine 4.40 13.7 µM 1.53E-6 ERG2 39 5.36E-6
5 SGTC_1248 0469-0687 4.39 58.6 µM 1.65E-6 15 5.75E-6
6 SGTC_1618 st003135 4.20 44.5 µM 4.22E-6 11 1.34E-5
7 SGTC_394 menadione 4.14 8.3 µM 5.54E-6 superoxide 26 1.71E-5
8 SGTC_1132 3456-3614 3.89 2.5 µM 1.80E-5 tubulin folding & SWR complex 48 4.94E-5
9 SGTC_69 0096-0274 3.76 206.7 µM 3.24E-5 mitochondrial processes 47 8.39E-5
10 SGTC_367 0335-0881 3.76 7.1 µM 3.24E-5 ubiquinone biosynthesis & proteasome 87 8.39E-5
11 SGTC_1715 st032160 3.58 10.2 µM 7.17E-5 55 1.72E-4
12 SGTC_1674 st016616 3.55 23.6 µM 8.00E-5 41 1.90E-4
13 SGTC_3308 9128332 3.55 17.6 µM 8.08E-5 plasma membrane duress 93 1.91E-4
14 SGTC_3194 9111903 3.42 49.5 µM 1.42E-4 41 3.17E-4
15 SGTC_3010 9080089 3.34 71.4 µM 1.91E-4 36 4.16E-4
16 SGTC_3249 9135183 3.33 49.5 µM 1.97E-4 60S ribosome export 33 4.28E-4
17 SGTC_1748 st037455 3.30 53.6 µM 2.30E-4 59 4.92E-4
18 SGTC_1267 0828-0272 3.29 9.5 µM 2.35E-4 44 5.00E-4
19 SGTC_697 0508-1955 3.17 564.0 µM 3.68E-4 68 7.50E-4
20 SGTC_2017 5132927 3.15 60.6 µM 4.02E-4 68 8.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 1.04E-54 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.246 1.46E-47 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.236 9.31E-44 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.232 2.50E-42 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.220 5.50E-38 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.215 2.25E-36 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.201 6.68E-32 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.198 5.90E-31 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184 6.14E-27 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.183 1.40E-26 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.182 2.68E-26 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.181 3.14E-26 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.180 8.48E-26 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.179 1.51E-25 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.175 1.67E-24 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C