YIL162W / SUC2

Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL162W / SUC2

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.90|P-value:7.83E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.41|P-value:4.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.32|P-value:8.17E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:5.00|P-value:6.81E-7 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:2.06E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.94|P-value:9.17E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.27|P-value:2.47E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:4.88|P-value:1.22E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:4.88|P-value:1.19E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:4.78|P-value:1.90E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.40|P-value:4.80E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.60|P-value:3.19E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.31|P-value:8.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.59|P-value:3.25E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.04|P-value:4.64E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-4.15|P-value:4.02E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.46|P-value:6.66E-8 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.39|P-value:6.59E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.27|P-value:9.58E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.65|P-value:3.44E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.02|P-value:5.06E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.45|P-value:4.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:3.82E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.63|P-value:2.17E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.01|P-value:5.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.33|P-value:6.27E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.57|P-value:2.67E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.49|P-value:6.91E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.38|P-value:1.00E-7 ID:SGTC_1964|Compound:st076914|FD-Score:-3.30|P-value:8.68E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.68|P-value:1.79E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-4.27|P-value:2.42E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.20|P-value:9.62E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.10|P-value:3.60E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.52|P-value:3.17E-4 ID:SGTC_2525|Compound:harmine|FD-Score:4.85|P-value:1.38E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.69|P-value:2.32E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.89|P-value:8.17E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.34|P-value:7.75E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.25|P-value:1.98E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.73|P-value:2.01E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.11|P-value:4.69E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.82|P-value:1.43E-4 ID:SGTC_3026|Compound:9090633|FD-Score:5.86|P-value:7.91E-9 ID:SGTC_3300|Compound:9124615|FD-Score:3.20|P-value:9.53E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.90|P-value:7.83E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.41|P-value:4.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.32|P-value:8.17E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:5.00|P-value:6.81E-7 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:2.06E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.94|P-value:9.17E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:-4.27|P-value:2.47E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:4.88|P-value:1.22E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:4.88|P-value:1.19E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:4.78|P-value:1.90E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.40|P-value:4.80E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.60|P-value:3.19E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.31|P-value:8.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.59|P-value:3.25E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.04|P-value:4.64E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-4.15|P-value:4.02E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.46|P-value:6.66E-8 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.39|P-value:6.59E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.27|P-value:9.58E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.65|P-value:3.44E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.02|P-value:5.06E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.45|P-value:4.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.55|P-value:3.82E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.63|P-value:2.17E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.01|P-value:5.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.33|P-value:6.27E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.57|P-value:2.67E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.49|P-value:6.91E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.38|P-value:1.00E-7 ID:SGTC_1964|Compound:st076914|FD-Score:-3.30|P-value:8.68E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.68|P-value:1.79E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-4.27|P-value:2.42E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.20|P-value:9.62E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.10|P-value:3.60E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.52|P-value:3.17E-4 ID:SGTC_2525|Compound:harmine|FD-Score:4.85|P-value:1.38E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.69|P-value:2.32E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.89|P-value:8.17E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.34|P-value:7.75E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.25|P-value:1.98E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.73|P-value:2.01E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.11|P-value:4.69E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.82|P-value:1.43E-4 ID:SGTC_3026|Compound:9090633|FD-Score:5.86|P-value:7.91E-9 ID:SGTC_3300|Compound:9124615|FD-Score:3.20|P-value:9.53E-4

Top fitness defect scores for YIL162W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3026 9090633 5.86 49.5 µM 7.91E-9 4 2.38E-9
2 SGTC_912 3474-0017 5.60 2.2 µM 3.19E-8 4 1.07E-8
3 SGTC_1134 3477-0009 5.46 42.5 µM 6.66E-8 14 2.37E-8
4 SGTC_1789 tunicamycin 5.38 25.0 nM 1.00E-7 unfolded protein response 25 3.67E-8
5 SGTC_545 4218-0007 5.00 221.0 µM 6.81E-7 10 2.89E-7
6 SGTC_813 k007-0158 4.88 173.0 µM 1.19E-6 fatty acid desaturase (OLE1) 17 5.28E-7
7 SGTC_810 3825-7150 4.88 143.0 µM 1.22E-6 60S ribosome export 3 5.41E-7
8 SGTC_2525 harmine 4.85 47.9 µM 1.38E-6 ergosterol biosynthesis 6 6.21E-7
9 SGTC_819 1013-0258 4.78 27.7 µM 1.90E-6 23 8.74E-7
10 SGTC_1314 1222-0010 4.65 41.1 µM 3.44E-6 5 1.65E-6
11 SGTC_1733 st037357 4.49 54.9 µM 6.91E-6 60S ribosome export 17 3.50E-6
12 SGTC_2882 9058044 4.25 58.4 µM 1.98E-5 11 1.09E-5
13 SGTC_2351 9026858 4.10 72.3 µM 3.60E-5 RNA processing & uracil transport 23 2.06E-5
14 SGTC_958 1222-0007 4.04 33.0 µM 4.64E-5 24 2.70E-5
15 SGTC_1326 1431-2094 4.02 10.8 µM 5.06E-5 tubulin folding & SWR complex 33 2.97E-5
16 SGTC_1610 st001799 4.01 48.1 µM 5.13E-5 12 3.01E-5
17 SGTC_2 0422-0095 3.90 29.0 µM 7.83E-5 redox potentiating 5 4.74E-5
18 SGTC_2647 atorvastatin 3.89 60.2 µM 8.17E-5 azole & statin 18 4.97E-5
19 SGTC_2602 kawain 3.82 100.0 µM 1.09E-4 32 6.73E-5
20 SGTC_2794 7785382 3.74 27.3 µM 1.47E-4 45 9.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 9.02E-10 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.093 5.76E-8 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.088 2.87E-7 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.088 3.20E-7 YBR200W-A_p YBR200W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.086 6.49E-7 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.083 1.28E-6 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.079 5.24E-6 YGR282C BGL2 hom Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
0.077 7.02E-6 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.077 7.78E-6 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.077 8.53E-6 YLR218C COA4 hom Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors
0.074 1.98E-5 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.073 2.48E-5 YNL158W PGA1 het Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
0.072 2.81E-5 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.072 3.24E-5 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.071 3.66E-5 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs