YIL164C / NIT1

Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL164C / NIT1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.44|P-value:1.32E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:9.57E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.17|P-value:5.04E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:3.54|P-value:8.60E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.94|P-value:1.49E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.14|P-value:4.22E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.69|P-value:4.45E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.29|P-value:2.39E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.90|P-value:1.76E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.20|P-value:3.34E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.24|P-value:3.51E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.56|P-value:1.09E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.90|P-value:2.24E-10 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.28|P-value:2.49E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.07|P-value:7.16E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.50|P-value:9.98E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.08|P-value:1.06E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.27|P-value:2.61E-4 ID:SGTC_1700|Compound:st030840|FD-Score:2.96|P-value:8.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.13|P-value:5.81E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-4.06|P-value:1.21E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.31|P-value:2.23E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.10|P-value:6.46E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.04|P-value:8.18E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.64|P-value:4.46E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.72|P-value:3.95E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.21|P-value:4.25E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.19|P-value:4.63E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.91|P-value:9.85E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.03|P-value:6.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.17|P-value:4.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.82|P-value:1.70E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-4.66|P-value:6.11E-7 ID:SGTC_2338|Compound:7999974|FD-Score:5.75|P-value:6.25E-10 ID:SGTC_2384|Compound:9036245|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.07|P-value:4.16E-8 ID:SGTC_2411|Compound:st077133|FD-Score:7.21|P-value:1.38E-14 ID:SGTC_2415|Compound:st077333|FD-Score:5.54|P-value:2.40E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.27|P-value:3.45E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.01|P-value:6.86E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.71|P-value:4.12E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:4.39|P-value:1.64E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:8.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.47|P-value:5.80E-9 ID:SGTC_2853|Compound:9015042|FD-Score:-3.67|P-value:6.86E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.45|P-value:1.24E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.74|P-value:3.70E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.06|P-value:7.59E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.44|P-value:1.32E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:9.57E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.17|P-value:5.04E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:3.54|P-value:8.60E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.94|P-value:1.49E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.14|P-value:4.22E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.69|P-value:4.45E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.29|P-value:2.39E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.90|P-value:1.76E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.20|P-value:3.34E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.24|P-value:3.51E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.56|P-value:1.09E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.90|P-value:2.24E-10 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.28|P-value:2.49E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.07|P-value:7.16E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.50|P-value:9.98E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.08|P-value:1.06E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.27|P-value:2.61E-4 ID:SGTC_1700|Compound:st030840|FD-Score:2.96|P-value:8.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.13|P-value:5.81E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-4.06|P-value:1.21E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.31|P-value:2.23E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.10|P-value:6.46E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.04|P-value:8.18E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.64|P-value:4.46E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.72|P-value:3.95E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.21|P-value:4.25E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.19|P-value:4.63E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.91|P-value:9.85E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.03|P-value:6.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.17|P-value:4.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.82|P-value:1.70E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-4.66|P-value:6.11E-7 ID:SGTC_2338|Compound:7999974|FD-Score:5.75|P-value:6.25E-10 ID:SGTC_2384|Compound:9036245|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.07|P-value:4.16E-8 ID:SGTC_2411|Compound:st077133|FD-Score:7.21|P-value:1.38E-14 ID:SGTC_2415|Compound:st077333|FD-Score:5.54|P-value:2.40E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.27|P-value:3.45E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.01|P-value:6.86E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.71|P-value:4.12E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:4.39|P-value:1.64E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:8.04E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.47|P-value:5.80E-9 ID:SGTC_2853|Compound:9015042|FD-Score:-3.67|P-value:6.86E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.45|P-value:1.24E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.74|P-value:3.70E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.06|P-value:7.59E-4

Top fitness defect scores for YIL164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2411 st077133 7.21 39.9 µM 1.38E-14 RNA pol III & RNase P/MRP 5 2.86E-13
2 SGTC_996 3970-0799 5.90 1.8 µM 2.24E-10 38 1.81E-9
3 SGTC_2338 7999974 5.75 200.0 µM 6.25E-10 3 4.58E-9
4 SGTC_2415 st077333 5.54 57.7 µM 2.40E-9 13 1.54E-8
5 SGTC_2398 5228213 5.07 48.8 µM 4.16E-8 iron homeostasis 14 2.03E-7
6 SGTC_2330 7979373 4.82 200.0 µM 1.70E-7 60S ribosome export 18 7.23E-7
7 SGTC_1971 st069429 4.64 63.5 µM 4.46E-7 60S ribosome export 5 1.73E-6
8 SGTC_2491 paeonol 4.39 100.0 µM 1.64E-6 6 5.61E-6
9 SGTC_942 3253-1115 4.24 227.0 µM 3.51E-6 23 1.11E-5
10 SGTC_130 0136-0219 3.94 337.7 µM 1.49E-5 22 4.10E-5
11 SGTC_657 3534-0529 3.90 86.7 µM 1.76E-5 13 4.77E-5
12 SGTC_84 0443-0269 3.81 128.8 µM 2.72E-5 25 7.07E-5
13 SGTC_2964 9083345 3.74 53.4 µM 3.70E-5 25 9.35E-5
14 SGTC_1201 1889-3372 3.73 45.9 µM 3.77E-5 Golgi 14 9.50E-5
15 SGTC_2013 4024628 3.72 200.0 µM 3.95E-5 52 9.90E-5
16 SGTC_2472 5377652 3.71 49.4 µM 4.12E-5 TRP & mitochondrial translation 71 1.03E-4
17 SGTC_419 nsc-638432 3.69 893.0 µM 4.45E-5 DNA damage response 14 1.10E-4
18 SGTC_80 0159-0065 3.54 512.2 µM 8.60E-5 6 2.00E-4
19 SGTC_69 0096-0274 3.51 206.7 µM 9.57E-5 mitochondrial processes 63 2.20E-4
20 SGTC_1309 pyrazolanthrone 3.50 13.4 µM 9.98E-5 32 2.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 7.11E-29 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.174 4.19E-24 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.164 1.11E-21 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.151 1.74E-18 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.145 2.98E-17 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.145 3.15E-17 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.134 8.14E-15 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.130 5.39E-14 YGL255W ZRT1 hom High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.126 2.68E-13 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.118 7.05E-12 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.115 1.99E-11 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.115 2.92E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.114 3.91E-11 YOR203W_d YOR203W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation
0.113 4.85E-11 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.113 5.20E-11 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele