YIL167W / SDL1

Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL167W / SDL1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.01|P-value:3.82E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:1.00E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.25|P-value:6.81E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.17|P-value:8.57E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.15|P-value:9.47E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.17|P-value:8.58E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.66|P-value:1.50E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.88|P-value:6.18E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.29|P-value:5.65E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.34|P-value:4.86E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.59|P-value:2.79E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:5.06|P-value:2.77E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.89|P-value:5.89E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.16|P-value:8.76E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.38|P-value:4.07E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.97|P-value:4.41E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.28|P-value:5.91E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.27|P-value:6.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.77|P-value:9.86E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.97|P-value:4.35E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.54|P-value:2.26E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:8.05E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.64|P-value:1.67E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.23|P-value:6.86E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.18|P-value:8.44E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.74|P-value:1.08E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.33|P-value:5.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.30|P-value:5.47E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.08|P-value:2.86E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.35|P-value:4.58E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.01|P-value:3.82E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:1.00E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.25|P-value:6.81E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.17|P-value:8.57E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.15|P-value:9.47E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.17|P-value:8.58E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.66|P-value:1.50E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.88|P-value:6.18E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.29|P-value:5.65E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.34|P-value:4.86E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.59|P-value:2.79E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:5.06|P-value:2.77E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.89|P-value:5.89E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.16|P-value:8.76E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.38|P-value:4.07E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.97|P-value:4.41E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.28|P-value:5.91E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.27|P-value:6.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.77|P-value:9.86E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.97|P-value:4.35E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.54|P-value:2.26E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:8.05E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.64|P-value:1.67E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.23|P-value:6.86E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.18|P-value:8.44E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.74|P-value:1.08E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.33|P-value:5.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.30|P-value:5.47E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.08|P-value:2.86E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.35|P-value:4.58E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.51|P-value:2.55E-4

Top fitness defect scores for YIL167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1222 0366-0074 5.06 1.2 µM 2.77E-7 TSC3-RPN4 3 2.09E-7
2 SGTC_1054 3429-0080 4.59 167.0 µM 2.79E-6 25 2.21E-6
3 SGTC_1288 0973-0013 4.22 65.5 µM 1.51E-5 11 1.25E-5
4 SGTC_1524 corynanthine 3.97 62.1 µM 4.35E-5 15 3.66E-5
5 SGTC_1236 0330-0013 3.89 258.0 µM 5.89E-5 8 5.00E-5
6 SGTC_596 1155-0152 3.88 116.0 µM 6.18E-5 TRP & mitochondrial translation 43 5.25E-5
7 SGTC_2698 st077697 3.74 67.5 µM 1.08E-4 20 9.30E-5
8 SGTC_2005 4024620 3.69 188.0 µM 1.28E-4 27 1.10E-4
9 SGTC_335 4077-0256 3.64 27.6 µM 1.59E-4 21 1.38E-4
10 SGTC_2972 9093619 3.60 59.9 µM 1.85E-4 27 1.61E-4
11 SGTC_2580 diallyl disulphide 3.59 81.4 µM 1.90E-4 29 1.65E-4
12 SGTC_2037 5169046 3.57 200.0 µM 2.02E-4 60S ribosome export 20 1.76E-4
13 SGTC_16 erodoxin 3.56 22.8 µM 2.10E-4 unfolded protein response 75 1.83E-4
14 SGTC_1540 guanosine 3.54 70.6 µM 2.26E-4 13 1.97E-4
15 SGTC_3355 9151058 3.51 44.0 µM 2.55E-4 RNA processing & uracil transport 17 2.24E-4
16 SGTC_1243 0416-0003 3.38 5.7 µM 4.07E-4 PDR1 55 3.60E-4
17 SGTC_2883 9059145 3.35 45.5 µM 4.58E-4 21 4.06E-4
18 SGTC_2790 5423970 3.30 71.4 µM 5.47E-4 endomembrane recycling 96 4.87E-4
19 SGTC_860 0443-0016 3.29 25.1 µM 5.65E-4 44 5.03E-4
20 SGTC_1477 0139-0234 3.28 16.0 µM 5.91E-4 23 5.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 2.20E-27 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.133 1.03E-14 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.122 1.36E-12 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.122 1.52E-12 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.119 5.13E-12 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.114 4.26E-11 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.108 3.82E-10 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.103 1.87E-9 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.097 1.58E-8 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.095 3.57E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.095 3.85E-8 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.093 6.67E-8 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.093 7.86E-8 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.090 1.75E-7 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.089 2.20E-7 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ