YIL168W

Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL168W / YIL168W

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:3.97|P-value:3.32E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.09|P-value:9.50E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.82|P-value:6.03E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.24|P-value:5.68E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.68|P-value:1.09E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:5.26|P-value:6.03E-8 ID:SGTC_544|Compound:k015-0020|FD-Score:3.91|P-value:4.14E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.16|P-value:1.32E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.69|P-value:1.18E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.15|P-value:7.25E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.10|P-value:9.10E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.29|P-value:7.93E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.10|P-value:8.54E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.01|P-value:2.69E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.59|P-value:1.54E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.34|P-value:3.99E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.27|P-value:8.83E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.97|P-value:3.26E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.31|P-value:4.44E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.08|P-value:9.09E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.19|P-value:6.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.55|P-value:1.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-4.07|P-value:1.92E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.14|P-value:7.46E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.85|P-value:5.44E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.10|P-value:1.86E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.41|P-value:4.59E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:5.11|P-value:1.35E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.11|P-value:1.74E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:9.80|P-value:2.81E-23 ID:SGTC_2835|Compound:9006588|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.74|P-value:8.34E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.14|P-value:7.41E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-5.10|P-value:1.25E-7 ID:SGTC_3000|Compound:9075062|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.49|P-value:3.09E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:3.97|P-value:3.32E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.09|P-value:9.50E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.82|P-value:6.03E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.24|P-value:5.68E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.68|P-value:1.09E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:5.26|P-value:6.03E-8 ID:SGTC_544|Compound:k015-0020|FD-Score:3.91|P-value:4.14E-5 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.16|P-value:1.32E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.69|P-value:1.18E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.15|P-value:7.25E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.10|P-value:9.10E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.29|P-value:7.93E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.10|P-value:8.54E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.01|P-value:2.69E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.59|P-value:1.54E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.34|P-value:3.99E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.27|P-value:8.83E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.97|P-value:3.26E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.31|P-value:4.44E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.08|P-value:9.09E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.19|P-value:6.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.55|P-value:1.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-4.07|P-value:1.92E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.14|P-value:7.46E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.85|P-value:5.44E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.10|P-value:1.86E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.41|P-value:4.59E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:5.11|P-value:1.35E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.11|P-value:1.74E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:9.80|P-value:2.81E-23 ID:SGTC_2835|Compound:9006588|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.74|P-value:8.34E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.14|P-value:7.41E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-5.10|P-value:1.25E-7 ID:SGTC_3000|Compound:9075062|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.49|P-value:3.09E-6

Top fitness defect scores for YIL168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2772 vinpocetine 9.80 57.1 µM 2.81E-23 1 5.73E-23
2 SGTC_429 1112-0049 5.26 25.5 µM 6.03E-8 DNA damage response 17 7.26E-8
3 SGTC_2763 lisinopril 5.11 49.3 µM 1.35E-7 2 1.60E-7
4 SGTC_265 mycophenolic acid 4.82 32.9 µM 6.03E-7 RPP1 & pyrimidine depletion 4 7.02E-7
5 SGTC_676 falcarinol 4.69 140.0 µM 1.18E-6 39 1.36E-6
6 SGTC_3004 9076122 4.49 71.4 µM 3.09E-6 10 3.52E-6
7 SGTC_2597 laccaic acid a 4.41 100.0 µM 4.59E-6 24 5.19E-6
8 SGTC_748 0136-0228 4.29 77.9 µM 7.93E-6 redox potentiating 70 8.91E-6
9 SGTC_1511 0906-3109 4.27 28.5 µM 8.83E-6 excess fatty acid 36 9.90E-6
10 SGTC_2769 toremifene 4.11 3.7 µM 1.74E-5 18 1.94E-5
11 SGTC_2328 6201408 4.10 200.0 µM 1.86E-5 17 2.06E-5
12 SGTC_1224 0823-0416 4.01 294.0 µM 2.69E-5 5 2.97E-5
13 SGTC_1823 3-hydroxy-2-naphthoic acid 3.97 106.0 µM 3.26E-5 14 3.59E-5
14 SGTC_138 0850-0259 3.97 40.9 µM 3.32E-5 cell wall 199 3.66E-5
15 SGTC_544 k015-0020 3.91 52.4 µM 4.14E-5 12 4.55E-5
16 SGTC_2256 7954252 3.85 200.0 µM 5.44E-5 mitochondrial processes 9 5.95E-5
17 SGTC_2848 9016370 3.74 26.0 µM 8.34E-5 30 9.08E-5
18 SGTC_399 oxolinic acid 3.68 75.0 µM 1.09E-4 11 1.19E-4
19 SGTC_3000 9075062 3.59 71.4 µM 1.51E-4 34 1.63E-4
20 SGTC_1416 3966-0321 3.59 25.3 µM 1.54E-4 28 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.20E-11 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.099 9.03E-9 YBL031W SHE1 hom Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
0.088 2.85E-7 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.088 3.53E-7 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.084 1.20E-6 YKL217W JEN1 hom Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
0.081 2.83E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.080 3.24E-6 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.078 5.44E-6 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.077 7.12E-6 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.076 1.02E-5 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.076 1.15E-5 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.075 1.30E-5 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.074 1.63E-5 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.072 3.14E-5 YHR176W FMO1 hom Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
0.070 4.89E-5 YDR319C_p YFT2_p hom Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens