YIL170W / HXT12

Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL170W / HXT12

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.24|P-value:3.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.41|P-value:5.93E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:3.15|P-value:4.55E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.12|P-value:3.38E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.00|P-value:2.84E-37 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.02|P-value:1.14E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:6.88|P-value:2.10E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:5.86|P-value:3.24E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.07|P-value:9.20E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.23|P-value:4.19E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:2.94|P-value:0.00100 ID:SGTC_278|Compound:4092-0821|FD-Score:7.00|P-value:8.16E-14 ID:SGTC_293|Compound:4049-0273|FD-Score:7.46|P-value:1.90E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.63|P-value:4.31E-16 ID:SGTC_658|Compound:3253-0951|FD-Score:4.81|P-value:2.07E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.39|P-value:1.78E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.20|P-value:3.74E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.45|P-value:1.28E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.30|P-value:3.01E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.36|P-value:8.01E-9 ID:SGTC_1521|Compound:st012942|FD-Score:3.91|P-value:1.91E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_1687|Compound:st020778|FD-Score:12.00|P-value:6.97E-37 ID:SGTC_1712|Compound:st032288|FD-Score:12.10|P-value:1.92E-37 ID:SGTC_1754|Compound:st042065|FD-Score:8.81|P-value:7.51E-21 ID:SGTC_1760|Compound:st045453|FD-Score:8.08|P-value:8.54E-18 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.52|P-value:1.06E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.59|P-value:1.98E-9 ID:SGTC_1801|Compound:st050089|FD-Score:7.85|P-value:6.28E-17 ID:SGTC_1803|Compound:st050068|FD-Score:6.94|P-value:1.28E-13 ID:SGTC_1818|Compound:st052136|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-2.95|P-value:8.78E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.92|P-value:1.07E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-4.24|P-value:3.58E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.07|P-value:6.17E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.60|P-value:7.53E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.39|P-value:1.77E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.64|P-value:6.26E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.47|P-value:1.11E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-5.52|P-value:2.69E-9 ID:SGTC_2060|Compound:5238662|FD-Score:3.72|P-value:4.45E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:7.89E-6 ID:SGTC_2257|Compound:7960413|FD-Score:4.27|P-value:3.41E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.72|P-value:4.50E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:15.20|P-value:4.54E-58 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.02|P-value:7.36E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.74|P-value:4.14E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:4.12E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.18|P-value:3.75E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.86|P-value:2.39E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.24|P-value:3.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.41|P-value:5.93E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:3.15|P-value:4.55E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.12|P-value:3.38E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:12.00|P-value:2.84E-37 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.02|P-value:1.14E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:6.88|P-value:2.10E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:5.86|P-value:3.24E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.07|P-value:9.20E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.23|P-value:4.19E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:2.94|P-value:0.00100 ID:SGTC_278|Compound:4092-0821|FD-Score:7.00|P-value:8.16E-14 ID:SGTC_293|Compound:4049-0273|FD-Score:7.46|P-value:1.90E-15 ID:SGTC_313|Compound:3474-0040|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.79|P-value:3.36E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.63|P-value:4.31E-16 ID:SGTC_658|Compound:3253-0951|FD-Score:4.81|P-value:2.07E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.39|P-value:1.78E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.20|P-value:3.74E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.45|P-value:1.28E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.30|P-value:3.01E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.36|P-value:8.01E-9 ID:SGTC_1521|Compound:st012942|FD-Score:3.91|P-value:1.91E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_1687|Compound:st020778|FD-Score:12.00|P-value:6.97E-37 ID:SGTC_1712|Compound:st032288|FD-Score:12.10|P-value:1.92E-37 ID:SGTC_1754|Compound:st042065|FD-Score:8.81|P-value:7.51E-21 ID:SGTC_1760|Compound:st045453|FD-Score:8.08|P-value:8.54E-18 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.52|P-value:1.06E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.59|P-value:1.98E-9 ID:SGTC_1801|Compound:st050089|FD-Score:7.85|P-value:6.28E-17 ID:SGTC_1803|Compound:st050068|FD-Score:6.94|P-value:1.28E-13 ID:SGTC_1818|Compound:st052136|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-2.95|P-value:8.78E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.92|P-value:1.07E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-4.24|P-value:3.58E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.07|P-value:6.17E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.46|P-value:1.36E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.60|P-value:7.53E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.39|P-value:1.77E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.64|P-value:6.26E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.47|P-value:1.11E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-5.52|P-value:2.69E-9 ID:SGTC_2060|Compound:5238662|FD-Score:3.72|P-value:4.45E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:7.89E-6 ID:SGTC_2257|Compound:7960413|FD-Score:4.27|P-value:3.41E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.72|P-value:4.50E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:15.20|P-value:4.54E-58 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.02|P-value:7.36E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.74|P-value:4.14E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:4.12E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.18|P-value:3.75E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.86|P-value:2.39E-5

Top fitness defect scores for YIL170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2752 diclazuril 15.20 33.1 µM 4.54E-58 7 2.07E-52
2 SGTC_1712 st032288 12.10 53.4 µM 1.92E-37 calcium & mitochondrial duress 10 7.16E-34
3 SGTC_146 3448-8650 12.00 53.1 µM 2.84E-37 NEO1-PIK1 12 1.02E-33
4 SGTC_1687 st020778 12.00 55.4 µM 6.97E-37 37 2.28E-33
5 SGTC_1754 st042065 8.81 16.1 µM 7.51E-21 NEO1-PIK1 41 6.00E-19
6 SGTC_1760 st045453 8.08 10.4 µM 8.54E-18 NEO1-PIK1 52 3.37E-16
7 SGTC_1801 st050089 7.85 28.4 µM 6.28E-17 NEO1-PIK1 28 2.03E-15
8 SGTC_528 3492-0019 7.63 172.0 µM 4.31E-16 calcium & mitochondrial duress 84 1.15E-14
9 SGTC_293 4049-0273 7.46 38.5 µM 1.90E-15 1 4.39E-14
10 SGTC_278 4092-0821 7.00 23.9 µM 8.16E-14 plasma membrane duress 12 1.29E-12
11 SGTC_1803 st050068 6.94 52.4 µM 1.28E-13 NEO1-PIK1 55 1.94E-12
12 SGTC_178 4092-0806 6.88 87.5 µM 2.10E-13 ergosterol depletion effects on membrane 28 3.03E-12
13 SGTC_158 k038-0087 6.02 26.4 µM 1.14E-10 ubiquinone biosynthesis & proteasome 67 8.80E-10
14 SGTC_207 4185-0010 5.86 4.5 µM 3.24E-10 endomembrane recycling 45 2.26E-9
15 SGTC_1800 st050079 5.59 29.1 µM 1.98E-9 NEO1-PIK1 51 1.16E-8
16 SGTC_86 0417-1630 5.41 471.9 µM 5.93E-9 ubiquinone biosynthesis & proteasome 101 3.11E-8
17 SGTC_1287 0971-0001 5.36 34.6 µM 8.01E-9 sphingolipid biosynthesis & PDR1 26 4.08E-8
18 SGTC_142 0335-0849 5.12 62.7 µM 3.38E-8 ubiquinone biosynthesis & proteasome 81 1.50E-7
19 SGTC_1877 wortmannin 4.92 25.0 µM 1.07E-7 65 4.24E-7
20 SGTC_658 3253-0951 4.81 102.0 µM 2.07E-7 calcium & mitochondrial duress 34 7.68E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.407 7.71E-134 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.378 9.74E-115 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.376 3.37E-113 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.374 4.78E-112 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.368 5.00E-108 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.363 5.53E-105 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.360 3.54E-103 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.359 2.25E-102 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.344 4.59E-94 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.339 3.96E-91 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.337 1.94E-89 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.336 1.69E-89 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.336 5.22E-89 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.324 8.21E-83 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.312 8.36E-77 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress