YIR003W / AIM21

Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR003W / AIM21

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.15|P-value:7.00E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.15|P-value:7.92E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.90|P-value:2.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.55|P-value:1.75E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.30|P-value:3.60E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:4.49|P-value:1.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.99|P-value:8.37E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.28|P-value:4.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.28|P-value:4.26E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.22|P-value:3.60E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.23|P-value:5.11E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.13|P-value:5.03E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.15|P-value:4.79E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.90|P-value:2.25E-5 ID:SGTC_1824|Compound:st053723|FD-Score:2.95|P-value:9.62E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.42|P-value:3.27E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-3.53|P-value:1.63E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.62|P-value:1.23E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.37|P-value:3.04E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.18|P-value:4.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:2.70E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.73|P-value:3.95E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.09|P-value:9.74E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.73|P-value:7.38E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.67|P-value:5.99E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.09|P-value:5.86E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.53|P-value:1.11E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.15|P-value:7.00E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.15|P-value:7.92E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.90|P-value:2.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.55|P-value:1.75E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.30|P-value:3.60E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:4.49|P-value:1.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.99|P-value:8.37E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.28|P-value:4.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.28|P-value:4.26E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.22|P-value:3.60E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.23|P-value:5.11E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.13|P-value:5.03E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.15|P-value:4.79E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.90|P-value:2.25E-5 ID:SGTC_1824|Compound:st053723|FD-Score:2.95|P-value:9.62E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.42|P-value:3.27E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-3.53|P-value:1.63E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.62|P-value:1.23E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.37|P-value:3.04E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.18|P-value:4.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:2.70E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.73|P-value:3.95E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.09|P-value:9.74E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.73|P-value:7.38E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.67|P-value:5.99E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.09|P-value:5.86E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.53|P-value:1.11E-6

Top fitness defect scores for YIR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.15 9.0 µM 7.92E-11 cell wall 206 4.00E-10
2 SGTC_2584 androsterone 4.73 48.7 µM 3.95E-7 cell wall 88 1.11E-6
3 SGTC_3304 9125678 4.53 46.1 µM 1.11E-6 32 2.92E-6
4 SGTC_671 0560-0003 4.49 407.0 µM 1.39E-6 6 3.59E-6
5 SGTC_354 2783-3500 4.30 4.9 µM 3.60E-6 cell wall 41 8.72E-6
6 SGTC_2610 ononetin 4.09 44.2 µM 9.74E-6 39 2.20E-5
7 SGTC_1788 fluconazole 3.90 20.0 µM 2.25E-5 azole & statin 62 4.80E-5
8 SGTC_165 k038-0023 3.90 64.4 µM 2.25E-5 ubiquinone biosynthesis & proteasome 80 4.80E-5
9 SGTC_2582 agaric acid 3.86 100.0 µM 2.70E-5 redox potentiating 327 5.69E-5
10 SGTC_2693 st077581 3.67 40.7 µM 5.99E-5 48 1.19E-4
11 SGTC_686 1319-0111 3.41 510.0 µM 1.77E-4 60S ribosome export 47 3.27E-4
12 SGTC_2364 9055074 3.30 200.0 µM 2.69E-4 37 4.81E-4
13 SGTC_2716 st080858 3.30 38.6 µM 2.70E-4 60S ribosome export 37 4.84E-4
14 SGTC_2708 st078559 3.30 56.0 µM 2.70E-4 17 4.84E-4
15 SGTC_1037 k284-1091 3.22 78.7 µM 3.60E-4 33 6.32E-4
16 SGTC_1713 st033146 3.20 12.8 µM 3.96E-4 59 6.91E-4
17 SGTC_2556 citropten 3.18 84.6 µM 4.31E-4 68 7.46E-4
18 SGTC_751 0833-0568 3.17 350.0 µM 4.41E-4 52 7.63E-4
19 SGTC_1645 Cervolide 3.15 78.0 µM 4.79E-4 24 8.23E-4
20 SGTC_1361 1608-0041 3.13 5.6 µM 5.03E-4 RPP1 & pyrimidine depletion 45 8.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 7.32E-47 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.229 3.33E-41 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.212 2.54E-35 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.210 6.70E-35 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.210 1.01E-34 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.209 2.50E-34 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.201 7.25E-32 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.183 1.75E-26 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.182 1.95E-26 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 5.51E-26 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.175 2.27E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.173 5.03E-24 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.169 5.78E-23 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.166 3.36E-22 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.166 4.40E-22 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain