YIR006C / PAN1

Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR006C / PAN1

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.11|P-value:2.01E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.84|P-value:6.56E-4 ID:SGTC_223|Compound:busulfan|FD-Score:2.91|P-value:4.51E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.86|P-value:5.69E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.19|P-value:1.42E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.34|P-value:7.29E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.82|P-value:7.11E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:2.84|P-value:6.18E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.20|P-value:1.35E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.35|P-value:7.40E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.04|P-value:2.20E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:2.96|P-value:3.71E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.18|P-value:1.46E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.50|P-value:3.32E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:2.91|P-value:4.50E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.84|P-value:6.13E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.08|P-value:2.29E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.85|P-value:1.96E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.87|P-value:1.50E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:2.93|P-value:4.20E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-2.79|P-value:8.05E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.86|P-value:5.54E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.24|P-value:7.63E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.17|P-value:1.04E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.48|P-value:1.95E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.48|P-value:4.12E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.14|P-value:1.71E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.33|P-value:4.09E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.46|P-value:4.05E-5 ID:SGTC_2088|Compound:5278280|FD-Score:4.22|P-value:7.83E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.88|P-value:5.09E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.00|P-value:4.47E-12 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.29|P-value:9.83E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.91|P-value:1.04E-11 ID:SGTC_2356|Compound:9061756|FD-Score:3.38|P-value:5.82E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-5.46|P-value:2.97E-10 ID:SGTC_2491|Compound:paeonol|FD-Score:4.01|P-value:2.47E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.00|P-value:2.69E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.74|P-value:3.84E-8 ID:SGTC_2505|Compound:galangin|FD-Score:3.17|P-value:1.54E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.79|P-value:7.29E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.85|P-value:6.31E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-2.96|P-value:4.11E-4 ID:SGTC_2782|Compound:7736369|FD-Score:2.85|P-value:5.95E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.54|P-value:2.85E-5 ID:SGTC_3107|Compound:9121808|FD-Score:2.91|P-value:4.64E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.02|P-value:2.94E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.11|P-value:2.01E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.84|P-value:6.56E-4 ID:SGTC_223|Compound:busulfan|FD-Score:2.91|P-value:4.51E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.86|P-value:5.69E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.19|P-value:1.42E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.34|P-value:7.29E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.82|P-value:7.11E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:2.84|P-value:6.18E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.20|P-value:1.35E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.35|P-value:7.40E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.04|P-value:2.20E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:2.96|P-value:3.71E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.18|P-value:1.46E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.50|P-value:3.32E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:2.91|P-value:4.50E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.84|P-value:6.13E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.08|P-value:2.29E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.85|P-value:1.96E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.87|P-value:1.50E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:2.93|P-value:4.20E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-2.79|P-value:8.05E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.86|P-value:5.54E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.24|P-value:7.63E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.17|P-value:1.04E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.48|P-value:1.95E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.48|P-value:4.12E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.14|P-value:1.71E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.33|P-value:4.09E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.46|P-value:4.05E-5 ID:SGTC_2088|Compound:5278280|FD-Score:4.22|P-value:7.83E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.88|P-value:5.09E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.00|P-value:4.47E-12 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.29|P-value:9.83E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.91|P-value:1.04E-11 ID:SGTC_2356|Compound:9061756|FD-Score:3.38|P-value:5.82E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-5.46|P-value:2.97E-10 ID:SGTC_2491|Compound:paeonol|FD-Score:4.01|P-value:2.47E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.00|P-value:2.69E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.74|P-value:3.84E-8 ID:SGTC_2505|Compound:galangin|FD-Score:3.17|P-value:1.54E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.79|P-value:7.29E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.85|P-value:6.31E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-2.96|P-value:4.11E-4 ID:SGTC_2782|Compound:7736369|FD-Score:2.85|P-value:5.95E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.54|P-value:2.85E-5 ID:SGTC_3107|Compound:9121808|FD-Score:2.91|P-value:4.64E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.02|P-value:2.94E-4

Top fitness defect scores for YIR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2131 toluylene red 6.00 5.3 µM 4.47E-12 60S ribosome export 6 9.85E-10 0.46
2 SGTC_1084 voriconazole 4.87 435.0 nM 1.50E-8 azole & statin 6 5.54E-7 0.41
3 SGTC_1813 st051246 4.33 8.6 µM 4.09E-7 TSC3-RPN4 3 7.32E-6 0.56
4 SGTC_2088 5278280 4.22 127.4 µM 7.83E-7 4 1.22E-5 0.86
5 SGTC_1569 carminic acid 4.17 40.6 µM 1.04E-6 1 1.52E-5 0.57
6 SGTC_809 3998-0021 4.04 90.0 µM 2.20E-6 RNA processing & uracil transport 8 2.73E-5 0.26
7 SGTC_2491 paeonol 4.01 100.0 µM 2.47E-6 1 2.99E-5 0.47
8 SGTC_2493 resveratrol 4.00 26.1 µM 2.69E-6 3 3.20E-5 0.10
9 SGTC_994 3910-0338 3.84 138.0 µM 6.13E-6 calcium & mitochondrial duress 13 6.09E-5 0.02
10 SGTC_2799 7812892 3.54 81.8 µM 2.85E-5 superoxide 25 2.03E-4 0.14
11 SGTC_896 0964-0007 3.50 44.5 µM 3.32E-5 12 2.29E-4 0.05
12 SGTC_1967 st070177 3.46 51.4 µM 4.05E-5 14 2.68E-4 0.15
13 SGTC_2356 9061756 3.38 189.0 µM 5.82E-5 7 3.56E-4 0.08
14 SGTC_425 3825-7017 3.34 13.1 µM 7.29E-5 18 4.25E-4 0.02
15 SGTC_662 k832-1615 3.20 104.0 µM 1.35E-4 10 6.92E-4 0.09
16 SGTC_343 4130-2827 3.19 29.8 µM 1.42E-4 9 7.18E-4 0.08
17 SGTC_873 0591-4978 3.18 488.0 µM 1.46E-4 7 7.35E-4 0.07
18 SGTC_2505 galangin 3.17 7.9 µM 1.54E-4 RPP1 & pyrimidine depletion 10 7.67E-4 0.02
19 SGTC_1729 st035615 3.14 46.0 µM 1.71E-4 15 8.32E-4 0.01
20 SGTC_63 0099-0242 3.11 26.7 µM 2.01E-4 mitochondrial stress 36 9.43E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.31E-12 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.112 9.01E-11 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.105 1.20E-9 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.104 1.70E-9 YJR110W YMR1 hom Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
0.103 2.40E-9 YHR082C KSP1 hom Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.102 2.83E-9 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.102 3.06E-9 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.096 2.78E-8 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.092 9.98E-8 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.089 2.26E-7 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.087 3.99E-7 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.084 9.84E-7 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.080 3.69E-6 YHR178W STB5 hom Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
0.079 4.31E-6 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.079 4.37E-6 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress