YIR009W / MSL1

U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR009W / MSL1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.48|P-value:7.36E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.44|P-value:2.42E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:4.49|P-value:2.05E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:3.44|P-value:8.50E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.59|P-value:5.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.97|P-value:1.42E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.53|P-value:1.74E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.03|P-value:1.15E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.19|P-value:2.27E-11 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.92|P-value:1.17E-10 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.65|P-value:1.08E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:3.83E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.43|P-value:2.60E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.74|P-value:7.17E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.20|P-value:2.90E-14 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.80|P-value:2.59E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.17|P-value:7.00E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.48|P-value:6.52E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.11|P-value:8.50E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.56|P-value:5.77E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.56|P-value:5.70E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.69|P-value:3.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.55|P-value:5.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.86|P-value:2.07E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.43|P-value:8.76E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.60|P-value:1.47E-7 ID:SGTC_1988|Compound:st071872|FD-Score:4.10|P-value:8.88E-5 ID:SGTC_2013|Compound:4024628|FD-Score:6.23|P-value:5.78E-9 ID:SGTC_2307|Compound:7538926|FD-Score:5.31|P-value:5.90E-7 ID:SGTC_2314|Compound:7727897|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_2315|Compound:7733312|FD-Score:5.40|P-value:3.91E-7 ID:SGTC_2346|Compound:9031566|FD-Score:3.61|P-value:4.80E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.73|P-value:2.91E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.05|P-value:1.54E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:4.68|P-value:9.45E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.55|P-value:5.35E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.96|P-value:1.48E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.08|P-value:8.29E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.04|P-value:1.12E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.48|P-value:7.36E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.44|P-value:2.42E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:4.49|P-value:2.05E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:3.44|P-value:8.50E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.59|P-value:5.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.97|P-value:1.42E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.53|P-value:1.74E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.03|P-value:1.15E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.19|P-value:2.27E-11 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.92|P-value:1.17E-10 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.65|P-value:1.08E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:3.83E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.43|P-value:2.60E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.74|P-value:7.17E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.20|P-value:2.90E-14 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.80|P-value:2.59E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.17|P-value:7.00E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.48|P-value:6.52E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.11|P-value:8.50E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.56|P-value:5.77E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.56|P-value:5.70E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.69|P-value:3.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.55|P-value:5.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.86|P-value:2.07E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.43|P-value:8.76E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.60|P-value:1.47E-7 ID:SGTC_1988|Compound:st071872|FD-Score:4.10|P-value:8.88E-5 ID:SGTC_2013|Compound:4024628|FD-Score:6.23|P-value:5.78E-9 ID:SGTC_2307|Compound:7538926|FD-Score:5.31|P-value:5.90E-7 ID:SGTC_2314|Compound:7727897|FD-Score:3.72|P-value:3.36E-4 ID:SGTC_2315|Compound:7733312|FD-Score:5.40|P-value:3.91E-7 ID:SGTC_2346|Compound:9031566|FD-Score:3.61|P-value:4.80E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.73|P-value:2.91E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.05|P-value:1.54E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:4.68|P-value:9.45E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.55|P-value:5.35E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.96|P-value:1.48E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.08|P-value:8.29E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.04|P-value:1.12E-4

Top fitness defect scores for YIR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 8.20 9.0 µM 2.90E-14 Golgi 17 1.19E-16
2 SGTC_1019 4262-0212 7.19 3.4 µM 2.27E-11 ergosterol depletion effects on membrane 14 3.22E-13
3 SGTC_1053 3366-3204 6.92 134.0 µM 1.17E-10 cell wall 2 2.25E-12
4 SGTC_2013 4024628 6.23 200.0 µM 5.78E-9 14 2.29E-10
5 SGTC_2561 acetosyringone 6.05 100.0 µM 1.54E-8 5 7.31E-10
6 SGTC_1965 Pectolinarigenin 5.60 58.4 µM 1.47E-7 RPP1 & pyrimidine depletion 3 1.06E-8
7 SGTC_2315 7733312 5.40 200.0 µM 3.91E-7 8 3.37E-8
8 SGTC_2307 7538926 5.31 6.3 µM 5.90E-7 12 5.47E-8
9 SGTC_1299 1079-1439 4.74 3.7 µM 7.17E-6 TSC3-RPN4 4 1.05E-6
10 SGTC_2563 tomatine 4.68 8.5 µM 9.45E-6 25 1.46E-6
11 SGTC_1058 3448-5425 4.65 97.3 µM 1.08E-5 24 1.70E-6
12 SGTC_757 1066-0008 4.53 322.0 µM 1.74E-5 Golgi 12 2.99E-6
13 SGTC_347 4534-1311 4.49 26.2 µM 2.05E-5 RPP1 & pyrimidine depletion 8 3.64E-6
14 SGTC_121 0557-0495 4.44 61.3 µM 2.42E-5 calcium & mitochondrial duress 45 4.43E-6
15 SGTC_1260 0700-1617 4.43 7.8 µM 2.60E-5 calcium & mitochondrial duress 22 4.82E-6
16 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 4.17 54.9 µM 7.00E-5 redox potentiating 47 1.55E-5
17 SGTC_1622 st003707 4.11 19.4 µM 8.50E-5 calcium & mitochondrial duress 30 1.95E-5
18 SGTC_1988 st071872 4.10 53.4 µM 8.88E-5 8 2.06E-5
19 SGTC_2993 9054257 4.04 71.4 µM 1.12E-4 fatty acid desaturase (OLE1) 41 2.70E-5
20 SGTC_770 0389-1121 4.03 67.2 µM 1.15E-4 RPP1 & pyrimidine depletion 26 2.80E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.10E-13 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.114 3.12E-11 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.110 2.03E-10 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.105 1.09E-9 YPL206C PGC1 hom Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
0.099 8.61E-9 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.099 9.94E-9 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.70E-8 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.095 3.06E-8 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.093 7.15E-8 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.092 1.00E-7 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.089 2.38E-7 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.087 4.37E-7 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.087 4.62E-7 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.085 7.50E-7 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.083 1.68E-6 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13