YIR010W / DSN1

Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR010W / DSN1

Click on Significant Values for Screen Details ID:SGTC_279|Compound:1273-0055|FD-Score:3.33|P-value:3.43E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.58|P-value:1.31E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.13|P-value:6.48E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-5.28|P-value:3.17E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.72|P-value:6.54E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.95|P-value:2.15E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:3.20|P-value:5.52E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.30|P-value:3.80E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.51|P-value:1.71E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.01|P-value:9.90E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.33|P-value:3.21E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.97|P-value:2.35E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-4.00|P-value:2.06E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.65|P-value:9.81E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.74|P-value:6.68E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.49|P-value:2.07E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.46|P-value:1.89E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.59|P-value:1.23E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.24|P-value:4.37E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.37|P-value:3.69E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.41|P-value:2.37E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.72|P-value:7.41E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.43|P-value:1.33E-8 ID:SGTC_3210|Compound:9128157|FD-Score:3.20|P-value:5.43E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.49|P-value:1.83E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.09|P-value:7.56E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.33|P-value:3.43E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.58|P-value:1.31E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.13|P-value:6.48E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-5.28|P-value:3.17E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.72|P-value:6.54E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.95|P-value:2.15E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:3.20|P-value:5.52E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.38|P-value:2.61E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.30|P-value:3.80E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.51|P-value:1.71E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.45|P-value:2.20E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.01|P-value:9.90E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.33|P-value:3.21E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.97|P-value:2.35E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-4.00|P-value:2.06E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.65|P-value:9.81E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.74|P-value:6.68E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.52|P-value:1.63E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.49|P-value:2.07E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.46|P-value:1.89E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.59|P-value:1.23E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.24|P-value:4.37E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.37|P-value:3.69E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.41|P-value:2.37E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.72|P-value:7.41E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.43|P-value:1.33E-8 ID:SGTC_3210|Compound:9128157|FD-Score:3.20|P-value:5.43E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.49|P-value:1.83E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.09|P-value:7.56E-4

Top fitness defect scores for YIR010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_832 4083-0019 4.95 164.0 µM 2.15E-7 translation 15 3.67E-7 0.22
2 SGTC_2799 7812892 4.72 81.8 µM 7.41E-7 superoxide 11 1.20E-6 0.07
3 SGTC_2098 5376439 3.74 882.5 nM 6.68E-5 5 9.04E-5 0.01
4 SGTC_1975 st070967 3.65 30.8 µM 9.81E-5 12 1.31E-4 0.04
5 SGTC_2546 rhodinyl acetate 3.59 100.0 µM 1.23E-4 9 1.62E-4 0.01
6 SGTC_321 4534-3890 3.58 65.3 µM 1.31E-4 RPP1 & pyrimidine depletion 11 1.72E-4 0.04
7 SGTC_1130 3454-2858 3.56 15.9 µM 1.39E-4 NEO1 16 1.82E-4 0.07
8 SGTC_2100 5377183 3.52 190.0 µM 1.63E-4 60S ribosome export 12 2.13E-4 0.14
9 SGTC_1411 3909-8223 3.51 150.0 µM 1.71E-4 3 2.23E-4 0.24
10 SGTC_3296 9122258 3.49 64.0 µM 1.83E-4 redox potentiating 11 2.38E-4 0.05
11 SGTC_1699 st031318 3.45 29.1 µM 2.20E-4 3 2.85E-4 0.11
12 SGTC_2969 9091408 3.40 28.7 µM 2.60E-4 13 3.34E-4 0.05
13 SGTC_279 1273-0055 3.33 2.9 µM 3.43E-4 azole & statin 3 4.35E-4 0.09
14 SGTC_1410 3909-8106 3.30 77.9 µM 3.80E-4 4 4.80E-4 0.05
15 SGTC_3210 9128157 3.20 49.5 µM 5.43E-4 24 6.78E-4 0.03
16 SGTC_972 1319-0219 3.20 195.0 µM 5.52E-4 16 6.88E-4 0.01
17 SGTC_2568 diosmetin 3.06 100.0 µM 9.03E-4 21 0.00110 0.05
18 SGTC_3206 9114350 3.03 49.5 µM 0.00102 12 0.00124 0.03
19 SGTC_3203 9113543 3.00 49.5 µM 0.00112 23 0.00136 0.00
20 SGTC_3191 9110352 2.97 49.5 µM 0.00124 6 0.00150 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.39E-27 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.167 2.36E-22 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.159 2.47E-20 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.141 2.11E-16 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.134 7.51E-15 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.116 1.56E-11 YLR115W CFT2 het Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
0.116 1.89E-11 YMR141C_d YMR141C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.09E-11 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.115 2.81E-11 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.107 4.87E-10 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.104 1.43E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.102 3.29E-9 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.102 3.44E-9 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.100 6.03E-9 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.098 1.40E-8 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate