YIR011C / STS1

Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR011C / STS1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.36|P-value:4.90E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.02|P-value:1.09E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.53|P-value:2.60E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.98|P-value:4.57E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.79|P-value:9.71E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-4.64|P-value:1.90E-6 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.92|P-value:5.76E-5 ID:SGTC_397|Compound:arbidol|FD-Score:-3.34|P-value:4.23E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.23|P-value:6.24E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.32|P-value:1.06E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.77|P-value:2.50E-18 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.34|P-value:7.11E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.01|P-value:4.02E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.16|P-value:9.53E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-4.44|P-value:5.01E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.15|P-value:8.32E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.17|P-value:1.62E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.67|P-value:1.28E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.90|P-value:5.04E-5 ID:SGTC_1755|Compound:st041960|FD-Score:-3.13|P-value:8.79E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.81|P-value:9.16E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-3.54|P-value:2.10E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.41|P-value:4.04E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.61|P-value:1.97E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.93|P-value:4.56E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.50|P-value:2.38E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.55|P-value:2.44E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.06|P-value:3.22E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.57|P-value:2.27E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.69|P-value:1.46E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.69|P-value:1.46E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.36|P-value:4.90E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.02|P-value:1.09E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.53|P-value:2.60E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.98|P-value:4.57E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.79|P-value:9.71E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-4.64|P-value:1.90E-6 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.92|P-value:5.76E-5 ID:SGTC_397|Compound:arbidol|FD-Score:-3.34|P-value:4.23E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.23|P-value:6.24E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.32|P-value:1.06E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.77|P-value:2.50E-18 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.34|P-value:7.11E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.01|P-value:4.02E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.16|P-value:9.53E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-4.44|P-value:5.01E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.15|P-value:8.32E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-4.17|P-value:1.62E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.67|P-value:1.28E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.90|P-value:5.04E-5 ID:SGTC_1755|Compound:st041960|FD-Score:-3.13|P-value:8.79E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.81|P-value:9.16E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-3.54|P-value:2.10E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.41|P-value:4.04E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.61|P-value:1.97E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.93|P-value:4.56E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.50|P-value:2.38E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.55|P-value:2.44E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.06|P-value:3.22E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.57|P-value:2.27E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.69|P-value:1.46E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.69|P-value:1.46E-4

Top fitness defect scores for YIR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1133 3473-0247 8.77 50.0 µM 2.50E-18 RSC complex & mRNA processing 10 9.08E-19 0.35
2 SGTC_1134 3477-0009 5.34 42.5 µM 7.11E-8 5 4.58E-8 0.30
3 SGTC_959 1222-0044 4.32 107.0 µM 1.06E-5 4 7.72E-6 0.54
4 SGTC_2475 5812728 4.06 15.0 µM 3.22E-5 mitochondrial processes 15 2.42E-5 0.06
5 SGTC_1410 3909-8106 4.01 77.9 µM 4.02E-5 1 3.04E-5 0.50
6 SGTC_331 k048-0133 3.98 24.5 µM 4.57E-5 RSC & ERG11 12 3.46E-5 0.11
7 SGTC_396 dithiazanine 3.92 1.2 µM 5.76E-5 3 4.38E-5 0.36
8 SGTC_1891 st059073 3.81 26.2 µM 9.16E-5 TSC3-RPN4 7 7.06E-5 0.27
9 SGTC_376 3970-0862 3.79 59.1 µM 9.71E-5 9 7.50E-5 0.02
10 SGTC_1171 0368-0077 3.70 21.4 µM 1.37E-4 14 1.06E-4 0.19
11 SGTC_2756 carbadox 3.69 75.1 µM 1.46E-4 25 1.14E-4 0.05
12 SGTC_3305 9127027 3.69 53.8 µM 1.46E-4 7 1.14E-4 0.19
13 SGTC_2158 5657123 3.61 3.6 µM 1.97E-4 18 1.55E-4 0.15
14 SGTC_2634 4'-methoxyflavone 3.57 100.0 µM 2.27E-4 12 1.79E-4 0.02
15 SGTC_2439 5492030 3.55 7.2 µM 2.44E-4 8 1.93E-4 0.04
16 SGTC_256 clotrimazole 3.53 625.0 nM 2.60E-4 ergosterol depletion effects on membrane 27 2.06E-4 0.15
17 SGTC_2327 6189656 3.41 200.0 µM 4.03E-4 13 3.23E-4 0.11
18 SGTC_2066 5222451 3.41 176.0 µM 4.04E-4 heme biosynthesis & mitochondrial translocase 33 3.24E-4 0.03
19 SGTC_81 0411-0046 3.36 10.0 µM 4.90E-4 46 3.95E-4 0.18
20 SGTC_119 0121-0043 3.29 24.8 µM 6.29E-4 mitochondrial stress 35 5.10E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.99E-14 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.121 1.99E-12 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.120 2.63E-12 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.116 1.61E-11 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.108 2.95E-10 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.101 4.41E-9 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.100 5.64E-9 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.100 6.51E-9 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.099 8.35E-9 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.099 9.38E-9 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.096 2.88E-8 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.095 3.56E-8 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.094 5.10E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.091 1.28E-7 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.091 1.45E-7 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene