YIR015W / RPR2

Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR015W / RPR2

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:3.58|P-value:3.95E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.12|P-value:5.72E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.66|P-value:3.16E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.98|P-value:9.67E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.08|P-value:7.03E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.68|P-value:2.88E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.43|P-value:6.80E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.42|P-value:6.86E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-4.73|P-value:5.03E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:4.29|P-value:2.93E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:8.25E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.71|P-value:2.64E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.69|P-value:2.70E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.94|P-value:1.17E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.19|P-value:4.44E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.98|P-value:1.01E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.05|P-value:7.53E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.54|P-value:4.68E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.28|P-value:3.06E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-5.01|P-value:1.43E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.99|P-value:9.19E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.69|P-value:5.75E-6 ID:SGTC_2229|Compound:7354935|FD-Score:6.58|P-value:3.71E-10 ID:SGTC_2265|Compound:7929201|FD-Score:7.89|P-value:7.87E-14 ID:SGTC_2267|Compound:7931562|FD-Score:4.75|P-value:4.26E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.57|P-value:4.24E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.84|P-value:2.30E-8 ID:SGTC_2284|Compound:7945075|FD-Score:-3.90|P-value:1.38E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.40|P-value:7.13E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.42|P-value:1.73E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-3.45|P-value:6.35E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.62|P-value:3.64E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.36|P-value:8.62E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.60|P-value:8.14E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-4.34|P-value:2.56E-5 ID:SGTC_2915|Compound:7971052|FD-Score:4.64|P-value:7.11E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.36|P-value:8.23E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.67|P-value:2.98E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-5.70|P-value:5.10E-8 ID:SGTC_3098|Compound:9119039|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.32|P-value:9.47E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.54|P-value:4.78E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.69|P-value:5.07E-8 ID:SGTC_3327|Compound:9140648|FD-Score:-3.60|P-value:3.94E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.58|P-value:3.95E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.12|P-value:5.72E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.66|P-value:3.16E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.98|P-value:9.67E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.08|P-value:7.03E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.68|P-value:2.88E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.43|P-value:6.80E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.42|P-value:6.86E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-4.73|P-value:5.03E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:4.29|P-value:2.93E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:8.25E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.71|P-value:2.64E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.69|P-value:2.70E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.94|P-value:1.17E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.19|P-value:4.44E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.98|P-value:1.01E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.05|P-value:7.53E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.54|P-value:4.68E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.28|P-value:3.06E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-5.01|P-value:1.43E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.99|P-value:9.19E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.69|P-value:5.75E-6 ID:SGTC_2229|Compound:7354935|FD-Score:6.58|P-value:3.71E-10 ID:SGTC_2265|Compound:7929201|FD-Score:7.89|P-value:7.87E-14 ID:SGTC_2267|Compound:7931562|FD-Score:4.75|P-value:4.26E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.57|P-value:4.24E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.84|P-value:2.30E-8 ID:SGTC_2284|Compound:7945075|FD-Score:-3.90|P-value:1.38E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.40|P-value:7.13E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.42|P-value:1.73E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-3.45|P-value:6.35E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.62|P-value:3.64E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.36|P-value:8.62E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.60|P-value:8.14E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-4.34|P-value:2.56E-5 ID:SGTC_2915|Compound:7971052|FD-Score:4.64|P-value:7.11E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.36|P-value:8.23E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.67|P-value:2.98E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-5.70|P-value:5.10E-8 ID:SGTC_3098|Compound:9119039|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.32|P-value:9.47E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.54|P-value:4.78E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.69|P-value:5.07E-8 ID:SGTC_3327|Compound:9140648|FD-Score:-3.60|P-value:3.94E-4

Top fitness defect scores for YIR015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2265 7929201 7.89 200.0 µM 7.87E-14 1 1.55E-15 2.22
2 SGTC_2229 7354935 6.58 190.0 µM 3.71E-10 RSC complex & mRNA processing 10 2.39E-11 0.67
3 SGTC_2282 7944268 5.84 200.0 µM 2.30E-8 RPP1 & pyrimidine depletion 5 2.62E-9 0.76
4 SGTC_3295 9122362 5.69 53.6 µM 5.07E-8 2 6.45E-9 0.68
5 SGTC_2267 7931562 4.75 200.0 µM 4.26E-6 2 9.94E-7 0.39
6 SGTC_2179 6298986 4.69 200.0 µM 5.75E-6 heme requiring 3 1.40E-6 0.06
7 SGTC_2915 7971052 4.64 15.2 µM 7.11E-6 1 1.78E-6 1.00
8 SGTC_2830 7992007 4.60 71.4 µM 8.14E-6 8 2.07E-6 0.12
9 SGTC_2422 chlorphenesin carbamate 4.42 384.2 µM 1.73E-5 3 4.90E-6 0.06
10 SGTC_655 k060-0012 4.29 42.0 µM 2.93E-5 2 8.87E-6 0.08
11 SGTC_1674 st016616 4.28 23.6 µM 3.06E-5 5 9.33E-6 0.01
12 SGTC_1340 1486-1359 4.19 257.0 µM 4.44E-5 4 1.42E-5 0.45
13 SGTC_86 0417-1630 4.12 471.9 µM 5.72E-5 ubiquinone biosynthesis & proteasome 29 1.90E-5 0.07
14 SGTC_1436 4092-1007 4.05 8.3 µM 7.53E-5 3 2.59E-5 0.53
15 SGTC_2165 5727197 3.99 32.1 µM 9.19E-5 1 3.25E-5 0.73
16 SGTC_175 3793-3120 3.98 23.7 µM 9.67E-5 4 3.44E-5 0.08
17 SGTC_2779 methotrexate 3.95 400.0 µM 1.07E-4 15 3.84E-5 0.21
18 SGTC_3098 9119039 3.95 49.5 µM 1.08E-4 Golgi 8 3.89E-5 0.17
19 SGTC_2882 9058044 3.90 58.4 µM 1.31E-4 5 4.87E-5 0.04
20 SGTC_2414 st077232 3.80 92.9 µM 1.86E-4 7 7.23E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.43E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.098 1.28E-8 YBR228W SLX1 hom Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
0.093 7.44E-8 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.092 9.29E-8 YMR239C RNT1 het Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
0.081 2.64E-6 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.079 4.11E-6 YPR039W_d YPR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
0.076 9.37E-6 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.075 1.20E-5 YNL091W NST1 hom Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
0.073 2.28E-5 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose
0.073 2.29E-5 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.071 3.65E-5 YDL238C GUD1 hom Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
0.071 3.95E-5 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.069 6.30E-5 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.069 6.77E-5 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.069 7.03E-5 YER087C-B SBH1 hom Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p