YIR016W_p

Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR016W / YIR016W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.46|P-value:2.73E-7 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.41|P-value:6.32E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.80|P-value:8.36E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.81|P-value:7.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:5.78|P-value:3.93E-11 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.47|P-value:2.50E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:2.98|P-value:4.10E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.91|P-value:5.63E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:4.27|P-value:8.03E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.20|P-value:1.43E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.08|P-value:2.72E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.16|P-value:1.91E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.51|P-value:4.12E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.90|P-value:5.90E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:2.77|P-value:9.37E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.82|P-value:7.87E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.76|P-value:9.69E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.07|P-value:2.81E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.24|P-value:1.37E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:3.56E-4 ID:SGTC_1759|Compound:st043059|FD-Score:2.84|P-value:7.09E-4 ID:SGTC_1762|Compound:st045503|FD-Score:2.77|P-value:9.54E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.82|P-value:7.85E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.95|P-value:4.75E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.86|P-value:6.03E-6 ID:SGTC_1963|Compound:st076565|FD-Score:-3.36|P-value:7.11E-5 ID:SGTC_1985|Compound:st071382|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.94|P-value:4.82E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.55|P-value:3.32E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.65|P-value:2.05E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.73|P-value:1.38E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.39|P-value:6.96E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.43|P-value:2.55E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.13|P-value:1.97E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.87|P-value:5.56E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.45|P-value:5.22E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.43|P-value:3.17E-7 ID:SGTC_2787|Compound:5284540|FD-Score:2.89|P-value:5.92E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.84|P-value:7.10E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.91|P-value:5.57E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.14|P-value:2.10E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.93|P-value:4.44E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.89|P-value:6.03E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.46|P-value:2.73E-7 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.41|P-value:6.32E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.80|P-value:8.36E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.81|P-value:7.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:5.78|P-value:3.93E-11 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.47|P-value:2.50E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:2.98|P-value:4.10E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.91|P-value:5.63E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:4.27|P-value:8.03E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.20|P-value:1.43E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.08|P-value:2.72E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.16|P-value:1.91E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.51|P-value:4.12E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.90|P-value:5.90E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:2.77|P-value:9.37E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.82|P-value:7.87E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.76|P-value:9.69E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.07|P-value:2.81E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.24|P-value:1.37E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:3.56E-4 ID:SGTC_1759|Compound:st043059|FD-Score:2.84|P-value:7.09E-4 ID:SGTC_1762|Compound:st045503|FD-Score:2.77|P-value:9.54E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.82|P-value:7.85E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.95|P-value:4.75E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.86|P-value:6.03E-6 ID:SGTC_1963|Compound:st076565|FD-Score:-3.36|P-value:7.11E-5 ID:SGTC_1985|Compound:st071382|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.24|P-value:1.36E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.94|P-value:4.82E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.55|P-value:3.32E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.65|P-value:2.05E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.73|P-value:1.38E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.39|P-value:6.96E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.43|P-value:2.55E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.13|P-value:1.97E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.87|P-value:5.56E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.45|P-value:5.22E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.43|P-value:3.17E-7 ID:SGTC_2787|Compound:5284540|FD-Score:2.89|P-value:5.92E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.84|P-value:7.10E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.91|P-value:5.57E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.14|P-value:2.10E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.93|P-value:4.44E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.89|P-value:6.03E-4

Top fitness defect scores for YIR016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_420 mitomycin C 5.78 81.9 mM 3.93E-11 3 3.74E-9
2 SGTC_546 peri-Naphthalide 4.47 147.0 µM 2.50E-7 DNA damage response 10 3.90E-6
3 SGTC_73 0327-0325 4.46 16.2 µM 2.73E-7 DNA damage response 35 4.19E-6
4 SGTC_2768 sulfasalazine 4.43 50.2 µM 3.17E-7 9 4.71E-6
5 SGTC_655 k060-0012 4.27 42.0 µM 8.03E-7 7 9.86E-6
6 SGTC_644 1498-1197 3.91 63.3 µM 5.63E-6 21 4.65E-5
7 SGTC_1075 aripiprazole 3.90 15.2 µM 5.90E-6 34 4.83E-5
8 SGTC_2309 7664088 3.73 163.9 µM 1.38E-5 43 9.51E-5
9 SGTC_2308 7584454 3.65 197.6 µM 2.05E-5 30 1.30E-4
10 SGTC_2221 6807166 3.55 181.1 µM 3.32E-5 8 1.92E-4
11 SGTC_1053 3366-3204 3.51 134.0 µM 4.12E-5 cell wall 52 2.28E-4
12 SGTC_2676 harmalol 3.45 100.0 µM 5.22E-5 mitochondrial processes 25 2.75E-4
13 SGTC_249 wiskostatin 3.41 11.2 µM 6.32E-5 29 3.21E-4
14 SGTC_2379 9035213 3.39 200.0 µM 6.96E-5 45 3.47E-4
15 SGTC_64 000l-0018 3.24 272.1 µM 1.36E-4 ubiquinone biosynthesis & proteasome 197 5.91E-4
16 SGTC_2121 5257820 3.24 149.6 µM 1.36E-4 27 5.92E-4
17 SGTC_1435 4092-0789 3.24 56.7 µM 1.37E-4 plasma membrane duress 35 5.95E-4
18 SGTC_1010 4112-3296 3.16 15.2 µM 1.91E-4 49 7.77E-4
19 SGTC_3086 9117350 3.14 49.5 µM 2.10E-4 12 8.38E-4
20 SGTC_872 0588-0139 3.08 234.0 µM 2.72E-4 67 0.00103

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.14E-16 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.114 3.32E-11 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.105 1.04E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.103 2.37E-9 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.102 3.49E-9 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.102 3.84E-9 YLR265C NEJ1 hom Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
0.100 6.00E-9 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.097 2.13E-8 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.096 2.67E-8 YPR058W YMC1 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication
0.095 3.55E-8 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.094 5.55E-8 YGR250C YGR250C hom Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.094 5.48E-8 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.089 2.64E-7 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.087 4.07E-7 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.085 7.58E-7 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function