YIR017C / MET28

Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR017C / MET28

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:3.47|P-value:9.49E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.89|P-value:2.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.85|P-value:6.92E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.86|P-value:2.74E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.04|P-value:1.49E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.65|P-value:5.46E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:5.34|P-value:8.40E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:3.69|P-value:4.73E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.87|P-value:2.69E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.79|P-value:8.71E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.26|P-value:6.90E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.56|P-value:2.17E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-7.25|P-value:3.06E-11 ID:SGTC_2096|Compound:5468907|FD-Score:-4.65|P-value:1.31E-5 ID:SGTC_2101|Compound:5377231|FD-Score:-4.01|P-value:1.45E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.93|P-value:2.15E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.75|P-value:3.92E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.84|P-value:2.90E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.59|P-value:1.74E-9 ID:SGTC_2700|Compound:st077718|FD-Score:-3.72|P-value:3.81E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.25|P-value:1.26E-6 ID:SGTC_2914|Compound:7968218|FD-Score:-3.57|P-value:6.20E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-6.48|P-value:2.44E-9 ID:SGTC_2987|Compound:9018338|FD-Score:3.77|P-value:3.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.88|P-value:2.22E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.67|P-value:5.14E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.77|P-value:3.72E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.57|P-value:6.30E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.47|P-value:9.49E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.89|P-value:2.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.85|P-value:6.92E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.86|P-value:2.74E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.04|P-value:1.49E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.65|P-value:5.46E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:5.34|P-value:8.40E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:3.69|P-value:4.73E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.87|P-value:2.69E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.79|P-value:8.71E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.26|P-value:6.90E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.56|P-value:2.17E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-7.25|P-value:3.06E-11 ID:SGTC_2096|Compound:5468907|FD-Score:-4.65|P-value:1.31E-5 ID:SGTC_2101|Compound:5377231|FD-Score:-4.01|P-value:1.45E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.93|P-value:2.15E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.75|P-value:3.92E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.84|P-value:2.90E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:6.59|P-value:1.74E-9 ID:SGTC_2700|Compound:st077718|FD-Score:-3.72|P-value:3.81E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.25|P-value:1.26E-6 ID:SGTC_2914|Compound:7968218|FD-Score:-3.57|P-value:6.20E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-6.48|P-value:2.44E-9 ID:SGTC_2987|Compound:9018338|FD-Score:3.77|P-value:3.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.88|P-value:2.22E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.67|P-value:5.14E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.77|P-value:3.72E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.57|P-value:6.30E-4

Top fitness defect scores for YIR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2614 arthonioic acid 6.59 13.4 µM 1.74E-9 1 2.27E-11
2 SGTC_679 0422-0091 5.34 41.4 µM 8.40E-7 Golgi 10 4.61E-8
3 SGTC_2857 9024691 5.25 58.4 µM 1.26E-6 6 7.57E-8
4 SGTC_366 0181-0206 4.85 4.3 µM 6.92E-6 Golgi 18 6.17E-7
5 SGTC_1447 4239-0816 4.79 81.9 µM 8.71E-6 16 8.18E-7
6 SGTC_1985 st071382 4.56 65.5 µM 2.17E-5 11 2.52E-6
7 SGTC_1506 4226-2149 4.26 212.0 µM 6.90E-5 20 1.04E-5
8 SGTC_493 zm226600 4.04 134.0 µM 1.49E-4 mitochondrial processes 14 2.68E-5
9 SGTC_2168 5727979 3.93 200.0 µM 2.15E-4 18 4.20E-5
10 SGTC_1052 3253-3998 3.87 198.0 µM 2.69E-4 22 5.53E-5
11 SGTC_425 3825-7017 3.86 13.1 µM 2.74E-4 24 5.66E-5
12 SGTC_2464 5717415 3.84 7.7 µM 2.90E-4 18 6.06E-5
13 SGTC_3301 9125354 3.77 19.8 µM 3.72E-4 19 8.23E-5
14 SGTC_2987 9018338 3.77 71.4 µM 3.74E-4 RPP1 & pyrimidine depletion 23 8.28E-5
15 SGTC_2291 7917025 3.75 104.3 µM 3.92E-4 iron homeostasis 59 8.78E-5
16 SGTC_835 0312-0010 3.69 67.2 µM 4.73E-4 14 1.10E-4
17 SGTC_3208 9114115 3.67 49.5 µM 5.14E-4 49 1.22E-4
18 SGTC_582 0987-0078 3.65 156.0 µM 5.46E-4 calcium & mitochondrial duress 87 1.31E-4
19 SGTC_98 0074-0023 3.47 107.7 µM 9.49E-4 Golgi 58 2.59E-4
20 SGTC_2338 7999974 3.34 200.0 µM 0.00140 47 4.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.63E-16 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.112 7.64E-11 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.098 1.13E-8 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.098 1.23E-8 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.096 2.29E-8 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.094 4.83E-8 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.084 1.24E-6 YDR442W_d YDR442W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.35E-6 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.078 6.75E-6 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.077 7.90E-6 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.076 9.49E-6 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.075 1.47E-5 YKR071C DRE2 het Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
0.074 1.80E-5 YKL081W TEF4 hom Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
0.073 2.43E-5 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.073 2.44E-5 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio