YIR018C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR018C-A / YIR018C-A

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:7.59E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.32|P-value:1.92E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.62|P-value:8.95E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:6.08|P-value:1.67E-10 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.11|P-value:7.05E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.48|P-value:1.79E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:5.50|P-value:6.59E-9 ID:SGTC_922|Compound:1866-0035|FD-Score:3.23|P-value:4.08E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.01|P-value:9.33E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.02|P-value:1.60E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.12|P-value:1.01E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.14|P-value:9.15E-6 ID:SGTC_1647|Compound:st011722|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.68|P-value:6.92E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.07|P-value:7.54E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.35|P-value:2.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.18|P-value:5.04E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.26|P-value:4.08E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.02|P-value:1.64E-5 ID:SGTC_1992|Compound:st073643|FD-Score:-3.16|P-value:5.85E-4 ID:SGTC_1998|Compound:st075797|FD-Score:5.55|P-value:4.77E-9 ID:SGTC_2003|Compound:4023581|FD-Score:4.45|P-value:2.11E-6 ID:SGTC_2104|Compound:5389443|FD-Score:3.54|P-value:1.27E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.71|P-value:6.15E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.26|P-value:3.65E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.93|P-value:2.38E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-3.73|P-value:6.32E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.41|P-value:2.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.15|P-value:6.03E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.18|P-value:4.99E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.82|P-value:3.96E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.30|P-value:3.52E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.52|P-value:1.62E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.63|P-value:9.61E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.02|P-value:9.48E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.86|P-value:3.30E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.12|P-value:9.96E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.41|P-value:2.25E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.27|P-value:3.62E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.80|P-value:4.62E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:7.59E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.32|P-value:1.92E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.62|P-value:8.95E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:6.08|P-value:1.67E-10 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.11|P-value:7.05E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.48|P-value:1.79E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:5.50|P-value:6.59E-9 ID:SGTC_922|Compound:1866-0035|FD-Score:3.23|P-value:4.08E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.01|P-value:9.33E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.02|P-value:1.60E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.12|P-value:1.01E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.14|P-value:9.15E-6 ID:SGTC_1647|Compound:st011722|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.68|P-value:6.92E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.07|P-value:7.54E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.35|P-value:2.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.18|P-value:5.04E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.26|P-value:4.08E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.02|P-value:1.64E-5 ID:SGTC_1992|Compound:st073643|FD-Score:-3.16|P-value:5.85E-4 ID:SGTC_1998|Compound:st075797|FD-Score:5.55|P-value:4.77E-9 ID:SGTC_2003|Compound:4023581|FD-Score:4.45|P-value:2.11E-6 ID:SGTC_2104|Compound:5389443|FD-Score:3.54|P-value:1.27E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.71|P-value:6.15E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.26|P-value:3.65E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.93|P-value:2.38E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-3.73|P-value:6.32E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.41|P-value:2.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.15|P-value:6.03E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.18|P-value:4.99E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.82|P-value:3.96E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.30|P-value:3.52E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.52|P-value:1.62E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.63|P-value:9.61E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.02|P-value:9.48E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.86|P-value:3.30E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.12|P-value:9.96E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.41|P-value:2.25E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.27|P-value:3.62E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.80|P-value:4.62E-5

Top fitness defect scores for YIR018C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_522 1273-0010 6.08 11.6 µM 1.67E-10 60S ribosome export 4 6.01E-10
2 SGTC_1998 st075797 5.55 76.8 µM 4.77E-9 mitochondrial response to ROS 4 1.40E-8
3 SGTC_909 3448-9333 5.50 149.0 µM 6.59E-9 4 1.90E-8
4 SGTC_272 doxorubicin 5.32 8.1 µM 1.92E-8 anthracycline transcription coupled DNA repair 7 5.20E-8
5 SGTC_907 3448-6986 4.48 75.5 µM 1.79E-6 13 3.70E-6
6 SGTC_2003 4023581 4.45 200.0 µM 2.11E-6 cell wall signaling 27 4.31E-6
7 SGTC_1611 st001856 4.14 99.4 µM 9.15E-6 13 1.71E-5
8 SGTC_3029 9088683 4.12 49.5 µM 9.96E-6 22 1.85E-5
9 SGTC_1371 2421-0008 4.12 32.7 µM 1.01E-5 mitochondrial processes 30 1.87E-5
10 SGTC_1369 1866-0067 4.02 208.0 µM 1.60E-5 RPP1 & pyrimidine depletion 36 2.89E-5
11 SGTC_1991 st073000 4.02 8.9 µM 1.64E-5 NEO1 74 2.97E-5
12 SGTC_2468 5987765 3.93 72.9 µM 2.38E-5 15 4.20E-5
13 SGTC_1229 0139-0193 3.91 12.2 µM 2.57E-5 RSC complex & mRNA processing 10 4.52E-5
14 SGTC_3020 9089140 3.86 49.5 µM 3.30E-5 30 5.72E-5
15 SGTC_2645 abamectin 3.82 100.0 µM 3.96E-5 heme requiring 34 6.80E-5
16 SGTC_2243 6634756 3.71 200.0 µM 6.15E-5 24 1.03E-4
17 SGTC_1717 st033143 3.68 58.0 µM 6.92E-5 54 1.15E-4
18 SGTC_427 1354-0053 3.62 47.3 µM 8.95E-5 31 1.46E-4
19 SGTC_2104 5389443 3.54 200.0 µM 1.27E-4 27 2.04E-4
20 SGTC_865 0488-0499 3.52 301.0 µM 1.36E-4 26 2.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.89E-13 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.123 1.01E-12 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.093 6.99E-8 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.092 9.50E-8 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.088 3.40E-7 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.086 5.89E-7 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
0.081 2.69E-6 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
0.080 3.28E-6 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
0.077 8.01E-6 YHR185C PFS1 hom Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
0.076 1.09E-5 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.076 1.15E-5 YOL064C MET22 hom Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
0.074 1.64E-5 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.074 1.93E-5 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.074 1.95E-5 YKR086W PRP16 het DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
0.073 2.51E-5 YDR511W ACN9 hom Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes