YIR018W / YAP5

Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR018W / YAP5

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.00|P-value:7.65E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.67|P-value:5.18E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.30|P-value:2.44E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.14|P-value:4.41E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.33|P-value:2.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:6.10|P-value:5.26E-11 ID:SGTC_530|Compound:4358-1714|FD-Score:5.18|P-value:2.08E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:3.14|P-value:4.38E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.03|P-value:6.63E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:5.17|P-value:2.26E-8 ID:SGTC_899|Compound:1083-0020|FD-Score:3.11|P-value:4.95E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.51|P-value:8.92E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:3.00|P-value:7.61E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.55|P-value:8.65E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.56|P-value:8.14E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.91|P-value:1.77E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.04|P-value:6.43E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.28|P-value:2.60E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:7.70|P-value:1.89E-16 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.73|P-value:6.48E-10 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.24|P-value:3.03E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.33|P-value:2.16E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.20|P-value:3.61E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.39|P-value:1.67E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.84|P-value:2.42E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.10|P-value:5.20E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.55|P-value:8.79E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.20|P-value:3.53E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.39|P-value:1.68E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.47|P-value:1.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.46|P-value:1.19E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-3.69|P-value:4.67E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.33|P-value:2.11E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.74|P-value:3.78E-5 ID:SGTC_2360|Compound:9040895|FD-Score:-3.79|P-value:3.03E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-3.99|P-value:1.19E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.96|P-value:1.40E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:2.96|P-value:8.61E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.73|P-value:3.97E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.91|P-value:1.76E-5 ID:SGTC_2804|Compound:7954240|FD-Score:2.92|P-value:9.93E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-5.04|P-value:4.96E-8 ID:SGTC_2820|Compound:7989630|FD-Score:-4.54|P-value:7.88E-7 ID:SGTC_2888|Compound:9058547|FD-Score:3.39|P-value:1.65E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.22|P-value:3.32E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.10|P-value:7.04E-6 ID:SGTC_3110|Compound:9122132|FD-Score:3.14|P-value:4.54E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.10|P-value:5.23E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.30|P-value:2.38E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.78|P-value:3.12E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.00|P-value:7.65E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.67|P-value:5.18E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.30|P-value:2.44E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.14|P-value:4.41E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.33|P-value:2.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:6.10|P-value:5.26E-11 ID:SGTC_530|Compound:4358-1714|FD-Score:5.18|P-value:2.08E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:3.14|P-value:4.38E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.03|P-value:6.63E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:5.17|P-value:2.26E-8 ID:SGTC_899|Compound:1083-0020|FD-Score:3.11|P-value:4.95E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.51|P-value:8.92E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:3.00|P-value:7.61E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.55|P-value:8.65E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.56|P-value:8.14E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.91|P-value:1.77E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.04|P-value:6.43E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.28|P-value:2.60E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:7.70|P-value:1.89E-16 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.73|P-value:6.48E-10 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.24|P-value:3.03E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.33|P-value:2.16E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.20|P-value:3.61E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.39|P-value:1.67E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.84|P-value:2.42E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.10|P-value:5.20E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.55|P-value:8.79E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.20|P-value:3.53E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.39|P-value:1.68E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.47|P-value:1.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.46|P-value:1.19E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-3.69|P-value:4.67E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.33|P-value:2.11E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.74|P-value:3.78E-5 ID:SGTC_2360|Compound:9040895|FD-Score:-3.79|P-value:3.03E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-3.99|P-value:1.19E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.96|P-value:1.40E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:2.96|P-value:8.61E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.73|P-value:3.97E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.91|P-value:1.76E-5 ID:SGTC_2804|Compound:7954240|FD-Score:2.92|P-value:9.93E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-5.04|P-value:4.96E-8 ID:SGTC_2820|Compound:7989630|FD-Score:-4.54|P-value:7.88E-7 ID:SGTC_2888|Compound:9058547|FD-Score:3.39|P-value:1.65E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.22|P-value:3.32E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.10|P-value:7.04E-6 ID:SGTC_3110|Compound:9122132|FD-Score:3.14|P-value:4.54E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.10|P-value:5.23E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.30|P-value:2.38E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.78|P-value:3.12E-5

Top fitness defect scores for YIR018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1370 2001-0092 7.70 44.6 µM 1.89E-16 2 6.90E-15
2 SGTC_524 r073-0010 6.10 27.8 µM 5.26E-11 14 5.15E-10
3 SGTC_1381 2324-0066 5.73 62.1 µM 6.48E-10 7 4.88E-9
4 SGTC_530 4358-1714 5.18 28.0 µM 2.08E-8 14 1.09E-7
5 SGTC_896 0964-0007 5.17 44.5 µM 2.26E-8 6 1.18E-7
6 SGTC_943 3253-1379 4.51 105.0 µM 8.92E-7 17 3.18E-6
7 SGTC_2305 7443522 4.46 69.2 µM 1.19E-6 8 4.11E-6
8 SGTC_1628 st004252 4.39 77.7 µM 1.67E-6 12 5.56E-6
9 SGTC_3061 glucosamine 4.10 200.0 µM 7.04E-6 7 2.03E-5
10 SGTC_2549 cedrol 3.96 20.9 µM 1.40E-5 16 3.77E-5
11 SGTC_2781 5567276 3.91 71.4 µM 1.76E-5 49 4.61E-5
12 SGTC_2311 7694451 3.74 200.0 µM 3.78E-5 24 9.17E-5
13 SGTC_2772 vinpocetine 3.73 57.1 µM 3.97E-5 30 9.60E-5
14 SGTC_78 0336-0123 3.67 156.8 µM 5.18E-5 28 1.22E-4
15 SGTC_1134 3477-0009 3.56 42.5 µM 8.14E-5 60 1.83E-4
16 SGTC_1129 3453-1384 3.55 223.0 µM 8.65E-5 54 1.93E-4
17 SGTC_1880 MG-132 3.55 525.0 µM 8.79E-5 28 1.96E-4
18 SGTC_2761 levamisole 3.51 97.9 µM 1.00E-4 28 2.21E-4
19 SGTC_2888 9058547 3.39 13.0 µM 1.65E-4 16 3.46E-4
20 SGTC_2038 4100038 3.39 31.0 µM 1.68E-4 plasma membrane duress 77 3.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.87E-10 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.093 6.79E-8 YNL204C SPS18 hom Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
0.087 4.48E-7 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.086 6.60E-7 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.085 7.58E-7 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication
0.083 1.37E-6 YPL088W_p YPL088W_p hom Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.083 1.45E-6 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.079 4.78E-6 YDL129W YDL129W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.078 6.57E-6 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.078 6.66E-6 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.077 7.35E-6 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.074 1.94E-5 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.073 2.36E-5 YKL062W MSN4 hom Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication
0.073 2.55E-5 YOL098C_p YOL098C_p hom Putative metalloprotease
0.071 3.43E-5 YKL018W SWD2 het Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination