YIR020W-A_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR020W-A / YIR020W-A

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:3.40|P-value:5.18E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:4.38|P-value:1.21E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.18|P-value:2.75E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.43|P-value:4.07E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.27|P-value:8.16E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.46|P-value:4.31E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.44|P-value:7.39E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:5.58|P-value:3.51E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.28|P-value:6.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.17|P-value:9.69E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.63|P-value:2.02E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.16|P-value:2.96E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.68|P-value:1.95E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.76|P-value:2.17E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.48|P-value:3.95E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.22|P-value:2.36E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.81|P-value:1.70E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:5.83|P-value:8.69E-9 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.53|P-value:6.25E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.76|P-value:1.22E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.39|P-value:5.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.59|P-value:2.69E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.70|P-value:1.80E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.53|P-value:2.85E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.79|P-value:1.10E-4 ID:SGTC_2280|Compound:7785178|FD-Score:6.14|P-value:1.45E-9 ID:SGTC_2304|Compound:7443016|FD-Score:3.37|P-value:5.74E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.09|P-value:3.99E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.50|P-value:3.66E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.83|P-value:8.83E-9 ID:SGTC_2851|Compound:9015922|FD-Score:-4.96|P-value:6.82E-7 ID:SGTC_2868|Compound:9035608|FD-Score:4.38|P-value:1.20E-5 ID:SGTC_2904|Compound:7225135|FD-Score:3.25|P-value:8.82E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.24|P-value:7.70E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.40|P-value:5.18E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:4.38|P-value:1.21E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.18|P-value:2.75E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.43|P-value:4.07E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.27|P-value:8.16E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.46|P-value:4.31E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.44|P-value:7.39E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:5.58|P-value:3.51E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.28|P-value:6.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.45|P-value:3.83E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.17|P-value:9.69E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.63|P-value:2.02E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.16|P-value:2.96E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.68|P-value:1.95E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.76|P-value:2.17E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.48|P-value:3.95E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.22|P-value:2.36E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.81|P-value:1.70E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:5.83|P-value:8.69E-9 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.53|P-value:6.25E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.76|P-value:1.22E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.39|P-value:5.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.59|P-value:2.69E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.70|P-value:1.80E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.53|P-value:2.85E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.79|P-value:1.10E-4 ID:SGTC_2280|Compound:7785178|FD-Score:6.14|P-value:1.45E-9 ID:SGTC_2304|Compound:7443016|FD-Score:3.37|P-value:5.74E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.09|P-value:3.99E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.50|P-value:3.66E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.83|P-value:8.83E-9 ID:SGTC_2851|Compound:9015922|FD-Score:-4.96|P-value:6.82E-7 ID:SGTC_2868|Compound:9035608|FD-Score:4.38|P-value:1.20E-5 ID:SGTC_2904|Compound:7225135|FD-Score:3.25|P-value:8.82E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.24|P-value:7.70E-4

Top fitness defect scores for YIR020W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2280 7785178 6.14 200.0 µM 1.45E-9 1 4.06E-10
2 SGTC_1298 1079-1278 5.83 263.0 µM 8.69E-9 DNA damage response 2 2.73E-9
3 SGTC_2781 5567276 5.83 71.4 µM 8.83E-9 16 2.78E-9
4 SGTC_815 1582-0027 5.58 36.9 µM 3.51E-8 4 1.21E-8
5 SGTC_804 1595-0054 5.44 20.9 µM 7.39E-8 sphingolipid biosynthesis & PDR1 15 2.67E-8
6 SGTC_1259 0671-0132 4.81 43.0 µM 1.70E-6 7 7.54E-7
7 SGTC_1043 0916-0009 4.76 19.3 µM 2.17E-6 9 9.76E-7
8 SGTC_1336 1486-0901 4.53 104.0 µM 6.25E-6 16 3.01E-6
9 SGTC_2868 9035608 4.38 32.5 µM 1.20E-5 9 6.05E-6
10 SGTC_233 rapamycin 4.38 362.0 pM 1.21E-5 6 6.07E-6
11 SGTC_1238 0333-0287 4.22 48.8 µM 2.36E-5 Golgi 22 1.24E-5
12 SGTC_529 4076-0302 4.18 30.3 µM 2.75E-5 mitochondrial processes 16 1.46E-5
13 SGTC_970 1315-0089 4.16 19.5 µM 2.96E-5 RSC & ERG11 19 1.58E-5
14 SGTC_2587 piperic acid 4.09 92.2 µM 3.99E-5 20 2.17E-5
15 SGTC_573 3702-0553 3.81 84.7 µM 1.18E-4 16 6.87E-5
16 SGTC_1799 st045822 3.70 46.1 µM 1.80E-4 17 1.08E-4
17 SGTC_1015 4130-4525 3.68 82.0 µM 1.95E-4 60S ribosome export 30 1.18E-4
18 SGTC_1771 st048882 3.59 4.2 µM 2.69E-4 RPP1 & pyrimidine depletion 30 1.66E-4
19 SGTC_2589 lobaric acid 3.50 100.0 µM 3.66E-4 38 2.30E-4
20 SGTC_1063 disulfiram 3.48 1.8 µM 3.95E-4 38 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.084 1.09E-6 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.082 2.02E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.081 2.29E-6 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.079 4.30E-6 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077 7.49E-6 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.074 1.72E-5 YIR029W DAL2 hom Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.074 1.87E-5 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.073 2.53E-5 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
0.070 4.97E-5 YOR315W SFG1 hom Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
0.067 9.81E-5 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.067 1.10E-4 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.067 1.14E-4 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.066 1.20E-4 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.065 1.60E-4 YOL114C_p YOL114C_p hom Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
0.065 1.65E-4 YNL278W CAF120 hom Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication